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Therapeutic strategies to mitigate bone involvement in anorexia are still a matter for debate. Although resumption of menses and weight recovery appear to be essential, they are not always accompanied by a total reversal of bone loss. There are no studies in the literature demonstrating that oestrogen treatment is effective, and the best results seem to have been obtained with agents that induce bone formation\u2014such as IGF-1\u2014especially when associated with oestrogen. As such, bone management in anorexia remains difficult, hence, the importance of early detection and multidisciplinary follow-up.<\/jats:p>","DOI":"10.1136\/rmdopen-2019-001009","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T10:35:11Z","timestamp":1573727711000},"page":"e001009","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Factors influencing bone loss in anorexia nervosa: assessment and therapeutic options"],"prefix":"10.1136","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5754-6077","authenticated-orcid":false,"given":"Isabelle","family":"Legroux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cortet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"2020050723320075000_5.2.e001009.1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328365a24f"},{"key":"2020050723320075000_5.2.e001009.2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association . 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