{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:31:28Z","timestamp":1790415088639,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100002706","name":"AFA F\u00f6rs\u00e4kring","doi-asserted-by":"publisher","award":["120299"],"award-info":[{"award-number":["120299"]}],"id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2013-0194"],"award-info":[{"award-number":["2013-0194"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2019,11,7]]},"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We estimated the association between occupational exposures to five different organic dusts: wood, animal, paper, textile and flour dust and the risk of developing rheumatoid arthritis (RA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This population-based case\u2013control study analysed 12\u2009582 incident cases and 129\u2009335 controls. Participants were identified from national public authority and quality registers. Census data on occupations were collected 1960\u20132010 and we estimated the exposure to organic dust with the help of job-exposure matrices. We used logistic regression to assess the OR of seropositive or seronegative RA. Estimates were adjusted for the matching variables (sex, county, age and index year), education and occupational silica exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Exposure to animal dust was associated with an increased risk of RA among both men and women. The OR was 1.2 (95% CI=1.1 to 1.4) for seropositive RA and 1.3 (95% CI=1.1 to 1.5) for seronegative RA among ever exposed participants compared with unexposed. The risk increased with duration of exposure for seropositive RA, and participants who had been exposed in five or more censuses had an OR of 1.6 (95% CI=1.1 to 2.2, p for trend=0.003). Exposure to textile dust also generated a significant dose\u2013response relationship for seropositive RA (p for trend=0.014). We detected no association between exposure to wood, paper or flour dust and risk of RA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Overall, exposure to animal dust and textile dust was associated with an increased risk of developing RA. These observations give further support to the notion that airborne exposures are involved in the aetiology of RA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2019-001049","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T21:45:14Z","timestamp":1574372714000},"page":"e001049","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Occupational exposure to organic dusts and risk of developing rheumatoid arthritis: findings from a Swedish population-based case\u2013control study"],"prefix":"10.1136","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-1405","authenticated-orcid":false,"given":"Anna","family":"Ilar","sequence":"first","affiliation":[{"name":"Unit of Translational Epidemiology, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2221-8599","authenticated-orcid":false,"given":"Per","family":"Gustavsson","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-0701","authenticated-orcid":false,"given":"Pernilla","family":"Wiebert","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-6697","authenticated-orcid":false,"given":"Lars","family":"Alfredsson","sequence":"additional","affiliation":[{"name":"Unit of Translational Epidemiology, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"2025090313071044000_5.2.e001049.1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/imr.12379","article-title":"Mechanisms involved in triggering rheumatoid arthritis","volume":"269","author":"Catrina","year":"2016","journal-title":"Immunol Rev"},{"key":"2025090313071044000_5.2.e001049.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.38"},{"key":"2025090313071044000_5.2.e001049.3","doi-asserted-by":"crossref","DOI":"10.1186\/ar4498","article-title":"Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis","volume":"16","author":"Di Giuseppe","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2025090313071044000_5.2.e001049.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.120899"},{"key":"2025090313071044000_5.2.e001049.5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/acr.23321","article-title":"Occupation and risk of developing rheumatoid arthritis: results from a population-based case-control study","volume":"70","author":"Ilar","year":"2018","journal-title":"Arthritis Care Res"},{"key":"2025090313071044000_5.2.e001049.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.001"},{"key":"2025090313071044000_5.2.e001049.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.114694"},{"key":"2025090313071044000_5.2.e001049.8","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-000978","article-title":"Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study","volume":"5","author":"Ilar","year":"2019","journal-title":"RMD Open"},{"key":"2025090313071044000_5.2.e001049.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133371"},{"key":"2025090313071044000_5.2.e001049.10","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2003.007971"},{"key":"2025090313071044000_5.2.e001049.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208278"},{"key":"2025090313071044000_5.2.e001049.12","doi-asserted-by":"publisher","DOI":"10.1080\/02841860902718747"},{"key":"2025090313071044000_5.2.e001049.13","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2011-100285"},{"key":"2025090313071044000_5.2.e001049.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.22880"},{"key":"2025090313071044000_5.2.e001049.15","first-page":"986","article-title":"Socioeconomic and occupational risk factors for rheumatoid arthritis: a nationwide study based on hospitalizations in Sweden","volume":"35","author":"Li","year":"2008","journal-title":"J Rheumatol"},{"key":"2025090313071044000_5.2.e001049.16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/03009749409099278","article-title":"Occupation, Occupational Exposure to Chemicals and Rheumatological Disease: A register based cohort study","volume":"23","author":"Lundberg","year":"1994","journal-title":"Scand J Rheumatol"},{"key":"2025090313071044000_5.2.e001049.17","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(01)00181-3"},{"key":"2025090313071044000_5.2.e001049.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.053"},{"key":"2025090313071044000_5.2.e001049.19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10654-018-0360-5","article-title":"Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case\u2013control study","volume":"33","author":"Hedstr\u00f6m","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"2025090313071044000_5.2.e001049.20","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<910::AID-ANR9>3.0.CO;2-D"},{"key":"2025090313071044000_5.2.e001049.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.9.835"},{"key":"2025090313071044000_5.2.e001049.22","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2018-105361"},{"key":"2025090313071044000_5.2.e001049.23","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1289\/EHP129","article-title":"Rheumatoid arthritis in agricultural health study spouses: associations with pesticides and other farm exposures","volume":"124","author":"Parks","year":"2016","journal-title":"Environ Health Perspect"},{"key":"2025090313071044000_5.2.e001049.24","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/jbmr.3745","article-title":"Combined Collagen\u2010Induced arthritis and organic Dust\u2010Induced airway inflammation to model inflammatory lung disease in rheumatoid arthritis","volume":"34","author":"Poole","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025090313071044000_5.2.e001049.25","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32835cee9a"},{"key":"2025090313071044000_5.2.e001049.26","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000202356.83509.f7"},{"key":"2025090313071044000_5.2.e001049.27","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050751"},{"key":"2025090313071044000_5.2.e001049.28","doi-asserted-by":"publisher","DOI":"10.1002\/art.21575"},{"key":"2025090313071044000_5.2.e001049.29","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022053"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2019-001049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:07:19Z","timestamp":1756930039000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2019-001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,11,21]]},"published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1136\/rmdopen-2019-001049"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2019-001049","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}