{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:17:10Z","timestamp":1772936230257,"version":"3.50.1"},"reference-count":23,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T00:00:00Z","timestamp":1580947200000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["A2225"],"award-info":[{"award-number":["A2225"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2020,1,19]]},"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Little is known about the prognosis of infections in patients with ankylosing spondylitis (AS) compared with patients without AS. The purpose of this study was to examine whether AS is associated with poorer outcomes in patients who are hospitalised with pneumonia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In a population-based cohort study including patients with hospitalised pneumonia with and without AS, we compared 90-day rates of mortality, all-cause readmission (90\u2009days post-discharge) and pulmonary complications including pulmonary embolism, empyema and pulmonary abscess. We used Cox regression analyses to compute crude and adjusted HRs while adjusting for sex, age and level of comorbidity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 387\u2009796 patients (median age 71 years) were hospitalised for pneumonia in Denmark between 1997 and 2017. Among these, 842 (0.2%) had AS (median age 65 years). The 90-day mortality was 12.5% in patients with AS and 15.5% in patients with non-AS pneumonia, with crude and adjusted 90-day HRs of 0.79 (95% CI 0.66 to 0.96) and 0.95 (95% CI 0.79 to 1.16), respectively. The 90-day post-discharge readmission rate was 27.3% in patients with AS and 25.4% in patients without AS, with a corresponding adjusted readmission HR of 1.12 (95% CI 0.98 to 1.27). Relative risk of pulmonary complications among patients with AS compared with patients without AS decreased over the study period, with adjusted HRs of 1.63 (95% CI 0.82 to 3.27) in 1997\u20132006 falling to 0.62 (95% CI 0.31 to 1.23) in 2007\u20132017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>AS is not associated with increased mortality following hospitalisation for pneumonia. Furthermore, no increased risk of readmission or pulmonary complications in patients with AS was detected in recent study years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2019-001140","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T04:55:41Z","timestamp":1581051341000},"page":"e001140","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Ankylosing spondylitis and mortality following hospitalised pneumonia: a population-based cohort study"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7628-7613","authenticated-orcid":false,"given":"Mette","family":"Holland-Fischer","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reimar W","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Tarp","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,2,6]]},"reference":[{"key":"2025090312140938000_6.1.e001140.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"2025090312140938000_6.1.e001140.2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207688"},{"key":"2025090312140938000_6.1.e001140.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.52.3.174"},{"key":"2025090312140938000_6.1.e001140.4","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2470"},{"key":"2025090312140938000_6.1.e001140.5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160942"},{"key":"2025090312140938000_6.1.e001140.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0130-0"},{"key":"2025090312140938000_6.1.e001140.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2014.05.004"},{"key":"2025090312140938000_6.1.e001140.8","first-page":"131","article-title":"Increased severity and mortality of CAP in COPD: results from the German competence network, CAPNETZ","volume":"2","author":"Braeken","year":"2015","journal-title":"Chronic Obs Pulm Dis"},{"key":"2025090312140938000_6.1.e001140.9","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-017-0424-4","article-title":"Prognostic factors in hospitalized community-acquired pneumonia: a retrospective study of a prospective observational cohort","volume":"17","author":"Ito","year":"2017","journal-title":"BMC Pulm Med"},{"key":"2025090312140938000_6.1.e001140.10","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-014-0434-7","article-title":"Pulmonary, renal and neurological comorbidities in patients with ankylosing spondylitis; implications for clinical practice","volume":"16","author":"Mercieca","year":"2014","journal-title":"Curr Rheumatol Rep"},{"key":"2025090312140938000_6.1.e001140.11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejim.2018.04.002","article-title":"The link between COPD and ankylosing spondylitis: a population based study","volume":"53","author":"Sharif","year":"2018","journal-title":"Eur J Intern Med"},{"key":"2025090312140938000_6.1.e001140.12","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"2025090312140938000_6.1.e001140.13","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811401482"},{"key":"2025090312140938000_6.1.e001140.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01629.x"},{"key":"2025090312140938000_6.1.e001140.15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2147\/CLEP.S99490","article-title":"The Danish nationwide clinical register for patients with rheumatoid arthritis: DANBIO","volume":"8","author":"Ibfelt","year":"2016","journal-title":"Clin Epidemiol"},{"key":"2025090312140938000_6.1.e001140.16","first-page":"2286","article-title":"A new approach to defining disease status in ankylosing spondylitis: the Bath ankylosing spondylitis disease activity index","volume":"21","author":"Garrett","year":"1994","journal-title":"J Rheumatol"},{"key":"2025090312140938000_6.1.e001140.17","first-page":"1694","article-title":"Defining spinal mobility in ankylosing spondylitis (AS). 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