{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:27:36Z","timestamp":1790652456945,"version":"4.1.0"},"reference-count":20,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2020,11,1]]},"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec id=\"s1\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Hepatitis E virus (HEV) represents the main cause of enterically transmitted hepatitis worldwide. It is known that neuralgic amyotrophy (NA) is one of the most frequent neurological manifestations of HEV. However, clinical, electrodiagnostic (EDX) and MRI characteristics, as well as long-term follow-up of HEV-related NA have not been fully described yet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"s2\">\n                  <jats:title>Case reports<\/jats:title>\n                  <jats:p>We describe longitudinally clinical, EDX, biological and MRI results of six cases of HEV-associated NA, diagnosed from 2012 to 2017. Patients were between the ages of 33 and 57\u00a0years old and had a positive HEV serology. Clinical patterns showed the whole spectrum of NA, varying from extensive multiple mononeuropathy damage to single mononeuropathy. EDX results showed that the patients totalised 26 inflammatory mononeuropathies (1 to 8 per patient). These involved classical nerves such as suprascapular (6\/6 cases), long thoracic (5\/6 cases) and accessory spinal nerves (2\/6 cases) and, some less frequent more distal nerves like anterior interosseous nerve (3\/6 cases), as well as some unusual ones such as the lateral antebrachial cutaneous nerve (1\/6 case), sensory fibres of median nerve (1\/6 case) and phrenic nerves (1\/6 case). After 2 to 8\u00a0years, all nerves had clinically recovered (muscle examination above 3\/5 on MRC scale for all muscles except in one patient).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"s3\">\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>HEV should be systematically screened when NA is suspected, whatever the severity, if the onset is less than 4\u00a0months (before IgM HEV-antibodies disappear) and appears to be frequently associated with severe clinical and EDX pattern, without increasing the usual recovery time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001401","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T07:01:21Z","timestamp":1605855681000},"page":"e001401","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Neuralgic amyotrophy and hepatitis E infection: 6 prospective case reports"],"prefix":"10.1136","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-819X","authenticated-orcid":false,"given":"Romain","family":"Garofoli","sequence":"first","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Seror","sequence":"additional","affiliation":[{"name":"D\u00e9partement De Neurophysiologie, Univ. Paris Pierre Et Marie Curie, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zauderer","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Roren","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Guerini","sequence":"additional","affiliation":[{"name":"Service de Radiologie ost\u00e9o-articulaire, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rannou","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"},{"name":"Universit\u00e9 Paris Descartes, PRES Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Drap\u00e9","sequence":"additional","affiliation":[{"name":"Service de Radiologie ost\u00e9o-articulaire, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"},{"name":"Universit\u00e9 de Paris, Facult\u00e9 de Sant\u00e9, UFR de M\u00e9decine, Paris, France"},{"name":"INSERM UMR-S 1124, Toxicit\u00e9 Environnementale, Cibles Th\u00e9rapeutiques, Signalisation Cellulaire et Biomarqueurs (T3S), Campus Saint-Germain-des-Pr\u00e9s, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Martine","family":"Lef\u00e8vre-Colau","sequence":"additional","affiliation":[{"name":"Service de R\u00e9\u00e9ducation et de R\u00e9adaptation de l\u2019Appareil Locomoteur et des Pathologies du Rachis, H\u00f4pital Cochin, AP-HP.Centre-Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"2025090313482815000_6.3.e001401.1","doi-asserted-by":"crossref","unstructured":"van Alfen N , van Engelen BG , Hughes RA . 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