{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:26:50Z","timestamp":1783114010827,"version":"3.54.6"},"reference-count":16,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"unspecified","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2020,12,28]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Peripheral ulcerative keratitis (PUK) is a rare but severe ocular complication of rheumatoid arthritis (RA). It can be considered as an ocular manifestation of rheumatoid vasculitis (RV). Our case series aimed to evaluate the efficacy of rituximab (RTX) for PUK occurring in patients with RA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Study population were patients with RA-associated PUK treated with RTX 1000\u2009mg on days 1 and 15 at least once after the diagnosis. We identified patients referred to the rheumatology and ophthalmology departments of our hospital between February 2014 and June 2020. We also included patients referred by their specialist after being contacted through the Club Rhumatismes et Inflammation. Demographic data and clinical and biological features were retrospectively collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included seven patients (three men and four women, median age 58 years). All but one had a long-standing RA with a median disease duration of 13.9 years (IQR 0\u201330.2). RA was erosive in six out of seven patients. All patients had rheumatoid factors and anticitrullinated peptides antibodies were positive in six of them. PUK was complicated by corneal perforation in three patients and required surgery. After a median follow-up of 29.8 months (IQR 5\u201375), corneal inflammation was controlled in all patients. PUK recurred in one patient, 8 months after a single infusion of RTX. 71% of the patients presented a good articular response. No patient developed other manifestations of RV. No serious adverse event related to RTX was observed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>RTX appears to be an efficient and safe therapeutic option in the treatment of RA-associated PUK.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001472","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T11:38:52Z","timestamp":1611833932000},"page":"e001472","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy and safety of rituximab in peripheral ulcerative keratitis associated with rheumatoid arthritis"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-4118","authenticated-orcid":false,"given":"Isabelle","family":"Bonnet","sequence":"first","affiliation":[{"name":"Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Ophtalmology, Hospital Bicetre, Le Kremlin-Bicetre, \u00cele-de-France, France"},{"name":"Immunology of Viral Infections and Autoimmune, Hematological and Bacterial Diseases, Inserm U1184, Le Kremlin-Bicetre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Duraffour","sequence":"additional","affiliation":[{"name":"Ophtalmology, Hospital Cochin, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pouchot","sequence":"additional","affiliation":[{"name":"Internat Medicine, Hopital Europeen Georges Pompidou, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Duc","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Centre Bethune, Bethune, Nord-Pas de Calais, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gabison","sequence":"additional","affiliation":[{"name":"Ophtalmology, H\u00f4pital Bichat Claude-Bernard, Paris, \u00cele-de-France, France"},{"name":"Centre de R\u00e9f\u00e9rence pour les Maladies Ren Ophtalmologie (OPHTARA), Fondation Rothschild, Paris, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaele","family":"Seror","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Immunology of Viral Infections and Autoimmune, Hematological and Bacterial Diseases, Inserm U1184, Le Kremlin-Bicetre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-9497","authenticated-orcid":false,"given":"Hubert","family":"Marotte","sequence":"additional","affiliation":[{"name":"Rhumatologie, CHU Saint-Etienne, Saint-Etienne, France"},{"name":"SAINBIOSE, INSERM U1059, University of Lyon, Saint-Etienne, France, University of Lyon, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Immunology of Viral Infections and Autoimmune, Hematological and Bacterial Diseases, Inserm U1184, Le Kremlin-Bicetre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetane","family":"Nocturne","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin Bic\u00eatre Hospital, Le Kremlin-Bic\u00eatre, France"},{"name":"Immunology of Viral Infections and Autoimmune, Hematological and Bacterial Diseases, Inserm U1184, Le Kremlin-Bicetre, \u00cele-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"2025090313090032000_7.1.e001472.1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/00003226-199001000-00013","article-title":"An analysis of therapeutic decision making regarding immunosuppressive chemotherapy for peripheral ulcerative 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Multicenter study of 34 patients","volume":"50","author":"Dominguez-Casas","year":"2020","journal-title":"Semin Arthritis Rheum"},{"key":"2025090313090032000_7.1.e001472.13","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1097\/ICO.0000000000000919","article-title":"Successful treatment strategies in granulomatosis with Polyangiitis-Associated peripheral ulcerative keratitis","volume":"35","author":"Ebrahimiadib","year":"2016","journal-title":"Cornea"},{"key":"2025090313090032000_7.1.e001472.14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.oftal.2011.01.003","article-title":"Rituximab in rheumatoid arthritis-associated peripheral ulcerative keratitis","volume":"86","author":"Albert","year":"2011","journal-title":"Arch Soc Esp Oftalmol Engl Ed"},{"key":"2025090313090032000_7.1.e001472.15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1055\/s-0042-121315","article-title":"Necrotising scleritis and peripheral ulcerative keratitis associated with rheumatoid arthritis treated with rituximab","volume":"234","author":"Hardy","year":"2017","journal-title":"Klin Monbl Augenheilkd"},{"key":"2025090313090032000_7.1.e001472.16","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep390"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2020-001472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:09:07Z","timestamp":1756930147000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2020-001472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,28]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/rmdopen-2020-001472"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2020-001472","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}