{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:20:35Z","timestamp":1793218835565,"version":"4.5.0"},"reference-count":20,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"unspecified","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2021,1,14]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the relevance of salivary gland ultrasound (SGUS) and its place in the diagnostic algorithm in patients referred with dry syndrome (DS) for a suspicion of Sj\u00f6gren\u2019s syndrome (SS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included all patients assessed at our dedicated DS clinic from June 2015 to September 2019 for which a SGUS has been carried out. Images were read blindly and the worst salivary gland was scored according to OMERACT classification. Clinical features, disease activity and treatments were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>337 patients were seen from June 2015 to September 2019. 269 patients underwent SGUS. 77 patients were diagnosed with SS and 192 did not meet the ACR\/EULAR criteria for SS: non-Sj\u00f6gren\u2019s DS (NSDS). Of these 192 patients, 60 had another possible cause of DS, and 132 patients were diagnosed with SAPS (sicca, asthenia, polyalgia syndrome).<\/jats:p>\n                  <jats:p>SGUS abnormalities were significantly higher in patients with SS versus NSDS: 51% vs 8% for a score \u22652 (p&lt;0.0001), and 43% vs 3% for a score \u22653 (p&lt;0.0001). SGUS score \u22652 had a specificity (Sp) of 91%, sensitivity (Se) of 57%, positive predictive value (PPV) of 72% and negative predictive value (NPV) of 82% for SS diagnosis. SGUS\u2019s characteristics in SSA-negative patients were similar to the whole population (Se=42%, Sp=91%, PPV=42%, NPV=92%). The high specificity and NPV in this population could avoid labial salivary gland biopsy (LSGB) in SSA-negative patients with normal SGUS (186 patients, 69%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SGUS is useful for SS diagnosis. If anti-SSA antibodies are negative and SGUS score &lt;2, the diagnosis of SS is very improbable and LSGB could be avoided.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001503","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T11:33:46Z","timestamp":1611833626000},"page":"e001503","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Normal salivary gland ultrasonography could rule out the diagnosis of Sj\u00f6gren\u2019s syndrome in anti-SSA-negative patients with sicca syndrome"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-7169","authenticated-orcid":false,"given":"Omar","family":"Al Tabaa","sequence":"first","affiliation":[{"name":"Rheumatology, Assistance Publique \u2013 H\u00f4pitaux de Paris, Hospital Bicetre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Gouze","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique \u2013 H\u00f4pitaux de Paris, Hospital Bicetre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-1249","authenticated-orcid":false,"given":"Sabrina","family":"Hamroun","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique \u2013 H\u00f4pitaux de Paris, Hospital Bicetre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Berg\u00e9","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique \u2013 H\u00f4pitaux de Paris, Hospital Bicetre, Le Kremlin-Bicetre, 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