{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:08:54Z","timestamp":1762956534468,"version":"3.44.0"},"reference-count":25,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["grant-number R349-2020-629"],"award-info":[{"award-number":["grant-number R349-2020-629"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2020,12,17]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>In Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender\/age\/diagnosis\/education\/work status\/comorbidity\/DMARD\/smoking\/EQ-5D\/disease activity) were explored with multivariable logistic regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 12\u2009789 patients (8168 rheumatoid arthritis\/2068 psoriatic arthritis\/1758 axial spondyloarthritis\/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March\/June: 70%\/45%) and self-isolated more than others of the same age (48%\/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%\/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In &gt;12\u2009000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients\u2019 anxiety and self-isolation is important during this and potential future epidemics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001505","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T15:24:10Z","timestamp":1609860250000},"page":"e001505","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-8482","authenticated-orcid":false,"given":"Bente","family":"Glintborg","sequence":"first","affiliation":[{"name":"DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte Vendelbo","family":"Jensen","sequence":"additional","affiliation":[{"name":"DANBIO, Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Rheumatology, Center for Rheumatology and Spine Diseases, Gentofte University Hospital, Hellerup, Hovedstaden, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Engel","sequence":"additional","affiliation":[{"name":"DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-9471","authenticated-orcid":false,"given":"Lene","family":"Terslev","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark"},{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Pfeiffer Jensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark"},{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Danish Hospital for Rheumatic Diseases, University of Southern Denmark, S\u00f8nderborg, Syddanmark, Denmark"},{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkel","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen Faculty of Health and Medical Sciences, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Horskj\u00e6r Rasmussen","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Adelsten","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sj\u00e6llands Universitetshospital K\u00f8ge, Koge, Sj\u00e6lland, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Colic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sj\u00e6llands Universitetshospital K\u00f8ge, Koge, Sj\u00e6lland, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla","family":"Danebod","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet Glostrup, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene","family":"Kildemand","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Gitte","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Midtjylland, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2212-6283","authenticated-orcid":false,"given":"Heidi Lausten","family":"Munk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Kristian","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Svendborg Hospital, Svendborg, Syddanmark, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 Drage","family":"\u00d8stg\u00e5rd","sequence":"additional","affiliation":[{"name":"Diagnostic Center, Silkeborg Regional Hospital, Silkeborg, Midtjylland, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"M\u00f8ller S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Regional Hospital Horsens, Horsens, Midtjylland, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Steen","family":"Krogh","sequence":"additional","affiliation":[{"name":"Zitelab Aps, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jette","family":"Agerbo","sequence":"additional","affiliation":[{"name":"Danish Rheumatism Association\/Gigtforeningen, 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