{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:05:39Z","timestamp":1793300739322,"version":"4.5.0"},"reference-count":21,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2021,4,2]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To describe salivary gland involvement in patients suspected of Sj\u00f6gren\u2019s syndrome (SS) using the OMERACT Ultrasound Scoring System for SS. Next, using different ultrasound cut-offs, to assess the performance of the scoring system for diagnosis and fulfilment of 2016 ACR\/EULAR SS classification criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients referred to our department with a suspicion of SS in a 12-month period were included. All underwent grey-scale ultrasound of the parotid and submandibular glands prior to clinical examination, Schirmer\u2019s test, unstimulated salivary flow, blood samples including autoantibody analysis. Labial biopsy was performed according to clinicians\u2019 judgement. Images of the four glands were scored 0\u20133 according to the scoring system and a consensus score was obtained using a developed ultrasound atlas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 134 patients included in the analysis, 43 were diagnosed with primary SS (pSS) and all fulfilled the 2016 American College of Rheumatology (ACR)\/EULAR classification criteria. More patients with pSS compared with non-pSS had score \u22652 in at least one gland (72% vs 13%; p&lt;0.001). In patients with score \u22652 in any gland, significantly more had positive autoantibodies, sialometry, Schirmer\u2019s test and positive labial biopsy compared with those with scores \u22641. The best ultrasound cut-off value for diagnosing pSS was \u22651 gland with a score \u22652 (sensitivity=0.72, specificity=0.91).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The OMERACT Ultrasound Scoring System showed good sensitivity (0.72) and excellent specificity (0.91) for fulfilling 2016 ACR\/EULAR criteria using cut-off score &gt;2 in at least one gland. Our data supports the use of ultrasound for diagnosing pSS and supports incorporation of ultrasound in the classification criteria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001516","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T18:29:22Z","timestamp":1618943362000},"page":"e001516","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Application of the OMERACT Grey-scale Ultrasound Scoring System for salivary glands in a single-centre cohort of patients with suspected Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1136","volume":"7","author":[{"given":"Viktoria","family":"Fana","sequence":"first","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe M","family":"Dohn","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Krabbe","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8193-9471","authenticated-orcid":false,"given":"Lene","family":"Terslev","sequence":"additional","affiliation":[{"name":"Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"2025090312285635000_7.2.e001516.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211250"},{"key":"2025090312285635000_7.2.e001516.2","first-page":"35","article-title":"2016 American College of Rheumatology\/European League against rheumatism classification criteria for primary Sj\u00f6gren's syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"2017","author":"Shiboski","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2025090312285635000_7.2.e001516.3","first-page":"1229","article-title":"Salivary gland ultrasonography in the evaluation of primary Sj\u00f6gren's syndrome. 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Comparison with minor salivary gland biopsy","volume":"27","author":"Salaffi","year":"2000","journal-title":"J Rheumatol"},{"key":"2025090312285635000_7.2.e001516.10","doi-asserted-by":"publisher","DOI":"10.1002\/art.37698"},{"key":"2025090312285635000_7.2.e001516.11","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh588"},{"key":"2025090312285635000_7.2.e001516.12","doi-asserted-by":"publisher","DOI":"10.3109\/03009740903270623"},{"key":"2025090312285635000_7.2.e001516.13","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215024"},{"key":"2025090312285635000_7.2.e001516.14","doi-asserted-by":"crossref","unstructured":"Finzel S , Jousse-Joulin S , Costantino F , et al . Patient-based reliability of the Outcome Measures in Rheumatology (OMERACT) ultrasound scoring system for salivary gland assessment in patients with Sj\u00f6gren\u2019s syndrome. Rheumatology. 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