{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:15:21Z","timestamp":1773371721353,"version":"3.50.1"},"reference-count":48,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2021,4,7]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Small studies suggest an association between ANCA-associated vasculitis (AAV) incidence and rurality, seasonality and socioeconomic deprivation. We examined the incidence of kidney biopsy-proven AAV and its relationship with these factors in the adult Scottish population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using the Scottish Renal Biopsy Registry, all adult native kidney biopsies performed between 2014 and 2018 with a diagnosis of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were identified. The Scottish Government Urban Rural Classification was used for rurality analysis. Seasons were defined as autumn (September\u2013November), winter (December\u2013February), spring (March\u2013May) and summer (June\u2013August). Patients were separated into quintiles of socioeconomic deprivation using the validated Scottish Index of Multiple Deprivation and incidence standardised to age. Estimated glomerular filtration rate and urine protein:creatinine ratio at time of biopsy were used to assess disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>339 cases of renal AAV were identified, of which 62% had MPA and 38% had GPA diagnosis. AAV incidence was 15.1 per million population per year (pmp\/year). Mean age was 66 years and 54% were female. Incidence of GPA (but not MPA) was positively associated with rurality (5.2, 8.4 and 9.1 pmp\/year in \u2018urban\u2019, \u2018accessible remote\u2019 and \u2018rural remote\u2019 areas, respectively; p=0.04). The age-standardised incidence ratio was similar across all quintiles of deprivation (p=ns).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Seasonality and disease severity did not vary across AAV study groups. In this complete national cohort study, we observed a positive association between kidney biopsy-proven GPA and rurality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2020-001555","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T12:55:06Z","timestamp":1618836906000},"page":"e001555","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["ANCA-associated renal vasculitis is associated with rurality but not seasonality or deprivation in a complete national cohort study"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-3220","authenticated-orcid":false,"given":"Oshorenua","family":"Aiyegbusi","sequence":"first","affiliation":[{"name":"Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, 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Inverness, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kelly","sequence":"additional","affiliation":[{"name":"Renal Unit, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzad","family":"Shah","sequence":"additional","affiliation":[{"name":"Renal Unit, Monklands Hospital, Airdrie, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Dey","sequence":"additional","affiliation":[{"name":"Renal Unit, University Hospital Crosshouse, Kilmarnock, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Buck","sequence":"additional","affiliation":[{"name":"Renal Unit, Queen Margaret Hospital, Fife Acute Hospitals Trust, Kirkcaldy, Fife, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn I","family":"Stevens","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin C","family":"Geddes","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily P","family":"McQuarrie","sequence":"additional","affiliation":[{"name":"Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"2025090313253617000_7.2.e001555.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24790"},{"key":"2025090313253617000_7.2.e001555.2","first-page":"301","article-title":"Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated 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