{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:20:13Z","timestamp":1783725613962,"version":"3.55.0"},"reference-count":31,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["61029829"],"award-info":[{"award-number":["61029829"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2021,9,14]]},"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess the incidence of amyloidosis and trends therein in patients with spondyloarthritis (SpA) over a long period (17 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational retrospective population-based matched cohort study was conducted. All the admissions of patients with SpA, including ankylosing spondylitis (AS), psoriatic arthritis (PsA), arthritis associated with inflammatory bowel disease (SpA-IBD) and reactive arthritis (ReA), reported between 1999 and 2015, were analysed and a control group matched by age, sex and year of admission was selected. Incidence rates for amyloidosis were calculated. Generalised linear models were used for trend analysis and unconditional logistic regression for calculating crude and adjusted ORs (AOR) to assess the association between amyloidosis and SpA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study database contained data on 107\u2009140 admissions in each group. Between 1999 and 2015, 792 patients in the SpA cohort (0.7% of all admissions) had a diagnosis of amyloidosis versus 68 in the non-SpA cohort (0.1%) (p&lt;0.001). From 1999 to 2015, incidence rates of amyloidosis tended to decrease in the SpA cohort (\u22124.63%\/year overall), while they increased in the Non-SpA cohort (+10.25%\/year overall). We found strong associations of amyloidosis with all SpAs (AOR 10.4; 95%\u2009CI 8.2 to 13.3) and with each type studied (AORs 10.05 (7.84 to 12. 88) for AS, 9.5 (7.3 to 12.4) for PsA, 22.9 (16.6 to 31.7) for SpA-IBD and 10.1 (6.1 to 16.7) for ReA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Incidence of amyloidosis among patients with SpA has strongly decreased in Spain. Amyloidosis is most strongly associated with SpA-IBD while the strength of association with PsA and ReA is similar to that with AS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2021-001782","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T13:47:09Z","timestamp":1633009629000},"page":"e001782","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in amyloidosis in spondyloarthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999\u20132015)\u2014TREND-EspA study"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-4719","authenticated-orcid":false,"given":"Ramon","family":"Mazzucchelli","sequence":"first","affiliation":[{"name":"Rheumatology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Alcorc\u00f3n, Spain"},{"name":"Department of Preventive Medicine and Public Health, Universidad Rey Juan Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Almodovar-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Alcorc\u00f3n, Spain"},{"name":"Department of Preventive Medicine and Public Health, Universidad Rey Juan Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Dieguez-Costa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital Vithas Nuestra Se\u00f1ora de Am\u00e9rica, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cresp\u00ed-Villar\u00edas","sequence":"additional","affiliation":[{"name":"Centro de Salud La Rivota, Alcorc\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"P\u00e9rez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Clinical Research, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda-Zamora","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n, Alcorc\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3262-8364","authenticated-orcid":false,"given":"Alberto","family":"Garcia Vadillo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,9,30]]},"reference":[{"key":"2025090313273414000_7.3.e001782.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"2025090313273414000_7.3.e001782.2","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1038\/nrdp.2015.13","article-title":"Axial spondyloarthritis","volume":"1","author":"Sieper","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"2025090313273414000_7.3.e001782.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2018.06.004"},{"key":"2025090313273414000_7.3.e001782.4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13506129.2019.1693359","article-title":"Causes of AA amyloidosis: a systematic 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Consumo y Bienestar Social - Estad\u00edsticas \/ Estudios - Sistema de Informaci\u00f3n Sanitaria del SNS. 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