{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:51:18Z","timestamp":1784019078350,"version":"3.55.0"},"reference-count":9,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,2,4]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age\u00b17 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Beh\u00e7et\u2019 disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age\u00b17 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2021-002063","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:57:21Z","timestamp":1653310641000},"page":"e002063","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI \u2013 the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-9074","authenticated-orcid":false,"given":"Rim","family":"Bourguiba","sequence":"first","affiliation":[{"name":"Sorbonne University, AP-HP, Tenon Hospital, Internal Medicine Department, 4 rue de la Chine, 75020, Paris, France; national Reference center for autoinflammatory diseases and AA amyloidosis (CEREMAIA), Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Kyheng","sequence":"additional","affiliation":[{"name":"Univ. Lille, CHU Lille, ULR 2694 - METRICS : \u00e9valuation des technologies de sant\u00e9 et des pratiques m\u00e9dicales, F-59000 Lille, France, CHU Lille, D\u00e9partement de Biostatistiques, F-59000 Lille, France, Universit\u00e9 de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-5763","authenticated-orcid":false,"given":"Isabelle","family":"Kon\u00e9-Paut","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie P\u00e9diatrique, Centre de R\u00e9f\u00e9rence des Maladies Auto-Inflammatoires de l\u2019enfant, H\u00f4pital Bic\u00eatre, AP HP, Universit\u00e9 Paris Sud, Bic\u00e8tre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Rouzaud","sequence":"additional","affiliation":[{"name":"Department of internal medicine, Bichat hospital, Paris, France, Bichat Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Avouac","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Service de Rhumatologie, H\u00f4pital Cochin, AP-HP.CUP, Paris, France, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Devaux","sequence":"additional","affiliation":[{"name":"CHI Poissy-Saint-Germain-en-Laye, Saint-Germain-en-Laye, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassim Ait","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine Interne: Maladies Auto-immunes et Pathologie Vasculaire (UF 04), Centre de Reference des Maladies autoimmunes systemiques Rares d\u2019Ile-de-France MATHEC, AP-HP, Hopital Saint-Louis, Paris, France, Universit\u00e9 de Paris, IRSL, Recherche clinique appliqu\u00e9e \u00e0 l\u2019h\u00e9matologie, EA, Paris, France, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-4274","authenticated-orcid":false,"given":"Bruno","family":"Fautrel","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 \u2013 Assistance Publique H\u00f4pitaux de Paris, Piti\u00e9 Salp\u00eatri\u00e8re University Hospital, Dept of Rhumatology, Reference Center for Rare Diseases CEREMAIA (ERN RITA), Paris, France. ii) Pierre Louis Institute of Epidemiology and Public Health, INSERM UMRS 1136, PEPITES team, Assistance Publique-Hopitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Ferreira-Maldent","sequence":"additional","affiliation":[{"name":"Internal Medecine, CHU Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Langlois","sequence":"additional","affiliation":[{"name":"GH du Havre-H\u00f4pital Jacques Monod, Le Havre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3925-9541","authenticated-orcid":false,"given":"Emmanuel","family":"Ledoult","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, Centre de R\u00e9f\u00e9rence des Maladies Auto-immunes et Syst\u00e9miques Rares du Nord et Nord-Ouest de France (CeRAINO), CHU Lille, F-59000 Lille, France 2- Inserm, U1286, F-59000 Lille, France, CHRU de Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Nielly","sequence":"additional","affiliation":[{"name":"H\u00f4pital d'Instructions des Arm\u00e9es B\u00e9gin, Saint Mande, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Queyrel","sequence":"additional","affiliation":[{"name":"Rheumatology department, CHU de Nice, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Sellam","sequence":"additional","affiliation":[{"name":"Rheumatology, INSERM UMRS_938, Sorbonnes Universit\u00e9 UPMC Univ Paris 06, St-Antoine Hospital, DHU i2B, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Tieulie","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie, H\u00f4pital Pasteur, Centre Hospitalier Universitaire, Universit\u00e9 de Nice Sophia Antipolis, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Chazerain","sequence":"additional","affiliation":[{"name":"Internal Medicine and Rheumatology, Groupe Hospitalier Diaconesses Croix Saint Simon, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Evon","sequence":"additional","affiliation":[{"name":"Internal Medecine department, CH de Bar-Le-Duc, Bar-le-Duc, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Labreuche","sequence":"additional","affiliation":[{"name":"Univ Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Savey","sequence":"additional","affiliation":[{"name":"Sorbonne University, AP-HP, Tenon Hospital, Internal Medicine Department, 4 rue de la Chine, 75020, Paris, France; national Reference center for autoinflammatory diseases and AA amyloidosis (CEREMAIA), Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Hentgen","sequence":"additional","affiliation":[{"name":"CeReMAI-Departement of Pediatrics Department of general pediatrics, Andre Mignot hospital, Versailles, CEREMAIA, France, H\u00f4pital Mignot, Le Chesnay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Grateau","sequence":"additional","affiliation":[{"name":"Sorbonne University, AP-HP, Tenon Hospital, Internal Medicine Department, 4 rue de la Chine, 75020, Paris, France; national Reference center for autoinflammatory diseases and AA amyloidosis (CEREMAIA), Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-8854","authenticated-orcid":false,"given":"Sophie","family":"Georgin-lavialle","sequence":"additional","affiliation":[{"name":"Sorbonne University, AP-HP, Tenon Hospital, Internal Medicine Department, 4 rue de la Chine, 75020, Paris, France; national Reference center for autoinflammatory diseases and AA amyloidosis (CEREMAIA), Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2025090313093271000_8.1.e002063.1","doi-asserted-by":"publisher","DOI":"10.1172\/jci137244"},{"key":"2025090313093271000_8.1.e002063.2","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keab577","article-title":"Incidence and course of COVID-19 hospitalizations among patients with familial Mediterranean fever","volume":"60","author":"Kharouf","year":"2021","journal-title":"Rheumatology"},{"key":"2025090313093271000_8.1.e002063.3","article-title":"Clinical course of COVID-19 in a cohort of 342 familial Mediterranean fever patients with a long-term treatment by colchicine in a French endemic area","author":"Bourguiba","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2025090313093271000_8.1.e002063.4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00296-021-04812-8","article-title":"COVID-19 outcomes in patients with familial Mediterranean fever: a retrospective cohort study","volume":"41","author":"G\u00fcven","year":"2021","journal-title":"Rheumatol Int"},{"key":"2025090313093271000_8.1.e002063.5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00296-021-04809-3","article-title":"COVID-19 in patients with familial Mediterranean fever treated with colchicine: case based review","volume":"41","author":"Nas","year":"2021","journal-title":"Rheumatol Int"},{"key":"2025090313093271000_8.1.e002063.6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.574593","article-title":"Familial Mediterranean fever and COVID-19: friends or Foes?","volume":"11","author":"Stella","year":"2020","journal-title":"Front Immunol"},{"key":"2025090313093271000_8.1.e002063.7","doi-asserted-by":"crossref","first-page":"e541","DOI":"10.1111\/jdv.17325","article-title":"Adamantiades-Beh\u00e7et's disease (Beh\u00e7et's disease) and COVID-19","volume":"35","author":"Zouboulis","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2025090313093271000_8.1.e002063.8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218310"},{"key":"2025090313093271000_8.1.e002063.9","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10091963","article-title":"Syndrome of undifferentiated recurrent fever (surf): an emerging group of autoinflammatory recurrent fevers","volume":"10","author":"Papa","year":"2021","journal-title":"J Clin Med"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2021-002063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:09:46Z","timestamp":1756930186000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2021-002063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,5,10]]},"published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1136\/rmdopen-2021-002063"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2021-002063","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}