{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T07:18:24Z","timestamp":1788679104506,"version":"build-2803163510"},"reference-count":23,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["Unrestricted research grant [MAIN457A_FVMH0]."],"award-info":[{"award-number":["Unrestricted research grant [MAIN457A_FVMH0]."]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Aidian Oy","award":["Provided testing kits free of charge"],"award-info":[{"award-number":["Provided testing kits free of charge"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,10,9]]},"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to evaluate the Disease Activity index for PSoriatic Arthritis (DAPSA) based on a quick quantitative C reactive protein (qCRP) assay (Q-DAPSA) in a multicentre, prospective, cross-sectional study in patients with psoriatic arthritis (PsA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The assessment of prospectively recruited study patients included joint examination and patient reported outcome (PRO) measures (patient global assessment, patient pain assessment). Following, the DAPSA based on a routine laboratory CRP measurement, Q-DAPSA and clinical DAPSA (cDAPSA) were calculated. Cross-tabulations and weighted Cohen\u2019s kappa were performed to analyse the agreement of disease activity categories. Bland-Altman plots and intraclass correlation coefficients were used to determine the agreement of numerical values regarding CRP and qCRP as well as different disease activity scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Altogether, 104 patients with PsA could be included in the statistical analysis. With Q-DAPSA, 102 of 104 (98.1%) patients achieved identical disease activity categories in comparison to DAPSA with a weighted Cohen\u2019s kappa of 0.980 (95% CI: 0.952 to 1.000). The agreement between DAPSA and cDAPSA was slightly lower with identical disease activity categories seen in 97 of 104 (93.3%) of patients and with a weighted Cohen\u2019s kappa of 0.932 (95% CI 0.885 to 0.980).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The Q-DAPSA showed an almost perfect agreement with the conventional DAPSA regarding identical disease activity categories. Thus, the Q-DAPSA can be used as a timely available disease activity score in patients with PsA with the additional benefit of CRP involvement. Consequently, the Q-DAPSA could facilitate the implementation of the treat-to-target concept in clinical routine and clinical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2022-002626","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T11:09:07Z","timestamp":1667387347000},"page":"e002626","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the Disease Activity index for PSoriatic Arthritis (DAPSA) with a quick quantitative C reactive protein assay (Q-DAPSA) in patients with psoriatic arthritis: a prospective multicentre cross-sectional study"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4306-033X","authenticated-orcid":false,"given":"Fabian","family":"Proft","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-2443","authenticated-orcid":false,"given":"Julia","family":"Schally","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning Christian","family":"Brandt","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Rheumatologie und Innere Medizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Brandt-Juergens","sequence":"additional","affiliation":[{"name":"Rheumatologische Schwerpunktpraxis, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-1131","authenticated-orcid":false,"given":"Gerd R\u00fcdiger","family":"Burmester","sequence":"additional","affiliation":[{"name":"Deparment of Rheumatology and Clinical Immunology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hildrun","family":"Haibel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"K\u00e4ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Karberg","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Rheumatologie und Innere Medizin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"L\u00fcders","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4104-5080","authenticated-orcid":false,"given":"Burkhard","family":"Muche","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-5069","authenticated-orcid":false,"given":"Mikhail","family":"Protopopov","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7442-2570","authenticated-orcid":false,"given":"Judith","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rios Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4600-9484","authenticated-orcid":false,"given":"Murat","family":"Torgutalp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryna","family":"Verba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Zinke","sequence":"additional","affiliation":[{"name":"Rheumapraxis Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-6015","authenticated-orcid":false,"given":"Denis","family":"Poddubnyy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Infectiology and Rheumatology (Including Nutrition Medicine), Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Epidemiology Unit, German Rheumatism Research Centre Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"2025090312121084000_8.2.e002626.1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41572-021-00293-y","article-title":"Psoriatic arthritis","volume":"7","author":"FitzGerald","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2025090312121084000_8.2.e002626.2","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1007\/s10067-021-05774-9","article-title":"Disease activity indices in psoriatic arthritis: current and evolving concepts","volume":"40","author":"Gialouri","year":"2021","journal-title":"Clin Rheumatol"},{"key":"2025090312121084000_8.2.e002626.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211734"},{"key":"2025090312121084000_8.2.e002626.4","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161473"},{"key":"2025090312121084000_8.2.e002626.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00347-5"},{"key":"2025090312121084000_8.2.e002626.6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201341"},{"key":"2025090312121084000_8.2.e002626.7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13075-021-02474-2","article-title":"Relationships between psoriatic arthritis composite measures of disease activity with patient-reported outcomes in phase 3 studies of tofacitinib","volume":"23","author":"Coates","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"2025090312121084000_8.2.e002626.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117945"},{"key":"2025090312121084000_8.2.e002626.9","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122259"},{"key":"2025090312121084000_8.2.e002626.10","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207507"},{"key":"2025090312121084000_8.2.e002626.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215960"},{"key":"2025090312121084000_8.2.e002626.12","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211998"},{"key":"2025090312121084000_8.2.e002626.13","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180971"},{"key":"2025090312121084000_8.2.e002626.14","doi-asserted-by":"publisher","DOI":"10.1186\/ar3049"},{"key":"2025090312121084000_8.2.e002626.15","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-002038"},{"key":"2025090312121084000_8.2.e002626.16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jbspin.2019.07.007","article-title":"Performance of the ankylosing spondylitis disease activity score based on a quick quantitative C-reactive protein assay in patients with axial spondyloarthritis","volume":"87","author":"Proft","year":"2020","journal-title":"Joint Bone Spine"},{"key":"2025090312121084000_8.2.e002626.17","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X221085951","article-title":"Validation of the ASDAS with a quick quantitative CRP assay (ASDAS-Q) in patients with axial spa: a prospective multicentre cross-sectional study","volume":"14","author":"Proft","year":"2022","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2025090312121084000_8.2.e002626.18","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X221114107","article-title":"Validation of the simplified disease activity index (SDAI) with a quick quantitative C-reactive protein assay (SDAI-Q) in patients with rheumatoid arthritis: a prospective multicenter cross-sectional study","volume":"14","author":"Schally","year":"2022","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2025090312121084000_8.2.e002626.19","unstructured":"QuikRead go wrCRP+Hb IFU (GB, DE, FR, IT) . Assay procedure. Available: https:\/\/www.aidian.eu\/point-of-care\/quikread-go\/quikread-go-wrcrphb#documents-and-materials [Accessed 05 Dec 2021]."},{"key":"2025090312121084000_8.2.e002626.20","unstructured":"McEnroe RJ , Durham AP , Goldford MD , et al . CLSI document EP05-A3. In: Evaluation of precision of quantitative measurement procedures; Approved guideline. Third edition. Wayne PA: Clinical and Laboratory Standards Institute, 2014."},{"key":"2025090312121084000_8.2.e002626.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133488"},{"key":"2025090312121084000_8.2.e002626.22","unstructured":"Koptyug E . Number of inhabitants in Berlin in Germany from 1960 to 2020. Available: https:\/\/www.statista.com\/statistics\/1109950\/number-of-inhabitants-berlin-germany\/ [Accessed 05 Dec 2021]."},{"key":"2025090312121084000_8.2.e002626.23","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2022-002626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:12:19Z","timestamp":1756926739000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2022-002626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1136\/rmdopen-2022-002626"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2022-002626","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]}}}