{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:42:11Z","timestamp":1793954531422,"version":"4.8.0"},"reference-count":40,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,10,31]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate effectiveness and safety of certolizumab pegol (CZP) in uveitis due to immune-mediated inflammatory diseases (IMID).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Multicentre study of CZP-treated patients with IMID uveitis refractory to conventional immunosuppressant. Effectiveness was assessed through the following ocular parameters: best-corrected visual acuity, anterior chamber cells, vitritis, macular thickness and retinal vasculitis. These variables were compared between the baseline, and first week, first, third, sixth months, first and second year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We studied 80 (33 men\/47 women) patients (111 affected eyes) with a mean age of 41.6\u00b111.7 years. The IMID included were: spondyloarthritis (n=43), Beh\u00e7et\u2019s disease (n=10), psoriatic arthritis (n=8), Crohn\u2019s disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1),<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2022-002693","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T09:37:15Z","timestamp":1670319435000},"page":"e002693","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-6633","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mart\u00edn-Varillas","sequence":"first","affiliation":[{"name":"Rheumatology, Hospital Comarcal de Laredo, Laredo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Sanchez-Bilbao","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Calvo-R\u00edo","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ad\u00e1n","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Hernanz","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Gallego-Flores","sequence":"additional","affiliation":[{"name":"Rheumatology, University Hospital Complex Badajoz, Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8070-6916","authenticated-orcid":false,"given":"Emma","family":"Beltran-Catalan","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Castro-Oreiro","sequence":"additional","affiliation":[{"name":"Rheumatology, Joan XXIII University Hospital in Tarragona, Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Fanlo","sequence":"additional","affiliation":[{"name":"Internal Medicine, Complejo Hospitalario de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Garcia Martos","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario del Tajo, Aranjuez, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Torre","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital de Basurto, Basurto, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Cordero-Coma","sequence":"additional","affiliation":[{"name":"Ophthalmology, Complejo Asistencial Universitario de Leon, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ramon","family":"De Dios","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Araba University Hospital, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Garc\u00eda-Aparicio","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario de Toledo, Toledo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Hern\u00e1ndez-Garfella","sequence":"additional","affiliation":[{"name":"Ophthalmology, General University Hospital Consortium of Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"S\u00e1nchez-Andrade","sequence":"additional","affiliation":[{"name":"Rheumatology, University Hospital Lucus Augusti, Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Garc\u00eda-Valle","sequence":"additional","affiliation":[{"name":"Rheumatology, Complejo Asistencial de Palencia, Palencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Maiz","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital of Donostia, San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Migu\u00e9lez","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario de Mostoles, Mostoles, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rodr\u00edguez-Montero","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Virgen de Valme, Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Urruticoechea","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Can Misses, Eivissa, Illes Balears, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Veroz","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital de Merida, Merida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Conesa","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital General Universitari de Castello, Castellon de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0910-4944","authenticated-orcid":false,"given":"Cristina","family":"Fern\u00e1ndez-Carballido","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario San Juan de Alicante, Sant Joan d'Alacant, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vega","family":"Jovan\u00ed","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital General Universitario de Alicante, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J","family":"Mondejar","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital General Universitario de Alicante, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Mart\u00ednez Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Moya Alvarado","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Romero-Yuste","sequence":"additional","affiliation":[{"name":"Rheumatology, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Rubio-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Rheumatology, Fundaci\u00f3 Hospital de l'Esperit Sant, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pe\u00f1a-Sainz-Pardo","sequence":"additional","affiliation":[{"name":"Pediatric, Hospital Universitario 12 de Octubre, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garijo-Bufort","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital de Sagunto, Sagunto, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Demetrio-Pablo","sequence":"additional","affiliation":[{"name":"Ophthalmology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-8847","authenticated-orcid":false,"given":"Jos\u00e9 L","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Internal Medicine, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"},{"name":"Medicine and Psychiatry Department, Universidad de Cantabria, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2344-2285","authenticated-orcid":false,"given":"Ricardo","family":"Blanco","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"2025090313574722000_8.2.e002693.1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Beh\u00e7et\u2019s Disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N Engl J Med Overseas Ed"},{"key":"2025090313574722000_8.2.e002693.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.05.032"},{"key":"2025090313574722000_8.2.e002693.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"2025090313574722000_8.2.e002693.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.1.110"},{"key":"2025090313574722000_8.2.e002693.5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203582"},{"key":"2025090313574722000_8.2.e002693.6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13075-016-1093-z","article-title":"Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis","volume":"18","author":"de Winter","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2025090313574722000_8.2.e002693.7","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200312000-00013"},{"key":"2025090313574722000_8.2.e002693.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem053"},{"key":"2025090313574722000_8.2.e002693.9","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjv213"},{"key":"2025090313574722000_8.2.e002693.10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.berh.2016.07.005","article-title":"Advancements in the management of uveitis","volume":"30","author":"Schwartzman","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025090313574722000_8.2.e002693.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509852"},{"key":"2025090313574722000_8.2.e002693.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31339-3"},{"key":"2025090313574722000_8.2.e002693.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.12.039"},{"key":"2025090313574722000_8.2.e002693.14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13075-018-1793-7","article-title":"Safety and efficacy of infliximab in the treatment of refractory uveoretinitis in Beh\u00e7et\u2019s disease: a large-scale, long-term postmarketing surveillance in Japan","volume":"21","author":"Ohno","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2025090313574722000_8.2.e002693.15","first-page":"1362","article-title":"Efficacy, safety, and pharmacokinetics of multiple administration of infliximab in Beh\u00e7et's disease with refractory uveoretinitis","volume":"31","author":"Ohno","year":"2004","journal-title":"J Rheumatol"},{"key":"2025090313574722000_8.2.e002693.16","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu266"},{"key":"2025090313574722000_8.2.e002693.17","first-page":"S34","article-title":"The effect of biologic therapy different from infliximab or adalimumab in patients with refractory uveitis due to Beh\u00e7et's disease: results of a multicentre open-label study","volume":"34","author":"Santos-G\u00f3mez","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313574722000_8.2.e002693.18","doi-asserted-by":"publisher","DOI":"10.1002\/art.21231"},{"key":"2025090313574722000_8.2.e002693.19","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem101"},{"key":"2025090313574722000_8.2.e002693.20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00296-015-3231-3","article-title":"Clinical management algorithm of uveitis associated with juvenile idiopathic arthritis: interdisciplinary panel consensus","volume":"35","author":"Bou","year":"2015","journal-title":"Rheumatol Int"},{"key":"2025090313574722000_8.2.e002693.21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.semarthrit.2015.05.010","article-title":"Anti-TNF-\u03b1 therapy in refractory uveitis associated with sarcoidosis: Multicenter study of 17 patients","volume":"45","author":"Riancho-Zarrabeitia","year":"2015","journal-title":"Semin Arthritis Rheum"},{"key":"2025090313574722000_8.2.e002693.22","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200300"},{"key":"2025090313574722000_8.2.e002693.23","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-001161","article-title":"The impact of certolizumab pegol treatment on the incidence of anterior uveitis flares in patients with axial spondyloarthritis: 48-week interim results from C-VIEW","volume":"6","author":"van der Horst-Bruinsma","year":"2020","journal-title":"RMD Open"},{"key":"2025090313574722000_8.2.e002693.24","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/14397595.2017.1285857","article-title":"Certolizumab Pegol treatment in Behcet\u2019s disease with different organ involvement: A multicenter retrospective observational study","volume":"27","author":"Lopalco","year":"2017","journal-title":"Modern Rheumatology"},{"key":"2025090313574722000_8.2.e002693.25","first-page":"652","article-title":"Golimumab in refractory uveitis associated to juvenile idiopathic arthritis: multicentre study of 7 cases and literature review","volume":"36","author":"Palmou-Fontana","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313574722000_8.2.e002693.26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40259-013-0064-z","article-title":"Pegylation of biological molecules and potential benefits: pharmacological properties of certolizumab pegol","volume":"28","author":"Pasut","year":"2014","journal-title":"BioDrugs"},{"key":"2025090313574722000_8.2.e002693.27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jri.2016.04.284","article-title":"Certolizumab pegol does not bind the neonatal Fc receptor (FcRn): consequences for FcRn-mediated in vitro transcytosis and ex vivo human placental transfer","volume":"116","author":"Porter","year":"2016","journal-title":"J Reprod Immunol"},{"key":"2025090313574722000_8.2.e002693.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"key":"2025090313574722000_8.2.e002693.29","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(85)34001-0"},{"key":"2025090313574722000_8.2.e002693.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"2025090313574722000_8.2.e002693.31","first-page":"167","article-title":"Certolizumab pegol, a new anti-TNF-\u03b1 in the armamentarium against ocular inflammation","volume":"24","author":"Lloren\u00e7","year":"2016","journal-title":"Ocul Immunol Inflamm"},{"key":"2025090313574722000_8.2.e002693.32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.55563\/clinexprheumatol\/j9ysbm","article-title":"Efficacy and safety of certolizumab pegol in pregnant women with uveitis. recommendations on the management with immunosuppressive and biologic therapies in uveitis during pregnancy","volume":"39","author":"Prieto-Pe\u00f1a","year":"2021","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313574722000_8.2.e002693.33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/acr.22848","article-title":"Observed incidence of uveitis following Certolizumab pegol treatment in patients with axial spondyloarthritis","volume":"68","author":"Rudwaleit","year":"2016","journal-title":"Arthritis Care Res"},{"key":"2025090313574722000_8.2.e002693.34","first-page":"680","article-title":"Efficacy and safety of certolizumab pegol and golimumab in the treatment of non-infectious uveitis","volume":"37","author":"Tosi","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313574722000_8.2.e002693.35","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X211003803","article-title":"Reduction of anterior uveitis flares in patients with axial spondyloarthritis on certolizumab pegol treatment: final 2-year results from the multicenter phase IV C-VIEW study","volume":"13","author":"van der Horst-Bruinsma","year":"2021","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2025090313574722000_8.2.e002693.36","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.ophtha.2018.02.020","article-title":"Successful optimization of adalimumab therapy in refractory uveitis due to Beh\u00e7et's disease","volume":"125","author":"Mart\u00edn-Varillas","year":"2018","journal-title":"Ophthalmology"},{"key":"2025090313574722000_8.2.e002693.37","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13512"},{"key":"2025090313574722000_8.2.e002693.38","first-page":"273","article-title":"Pregnancy concerns in women with inflammatory bowel disease","volume":"11","author":"Uma","year":"2015","journal-title":"Gastroenterol Hepatol"},{"key":"2025090313574722000_8.2.e002693.39","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/art.40508","article-title":"Pregnancy outcomes after exposure to Certolizumab pegol: updated results from a pharmacovigilance safety database","volume":"70","author":"Clowse","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2025090313574722000_8.2.e002693.40","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev356"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2022-002693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:57:56Z","timestamp":1756933076000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2022-002693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,6]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/rmdopen-2022-002693"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2022-002693","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}