{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:45:47Z","timestamp":1787838347664,"version":"build-2784847793"},"reference-count":31,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,11,17]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To analyse the influence of HLA-B27 in the phenotypical expression of peripheral spondyloarthritis (pSpA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>This is an observational cross-sectional study using data from the Assessment of SpondyloArthritis international Society perSpA registry, including all patients with an available HLA-B27 test result and with a diagnosis of pSpA or psoriatic arthritis (PsA) as per rheumatologist\u2019s judgement. Demographic and clinical data, presence of extra musculoskeletal manifestations (EMM) and fibromyalgia were the variables included in a simple and multiple logistic regression model to assess their association to HLA-B27 positivity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From the 4465 patients included in the registry, 790 were classified as having either pSpA or PsA and had the HLA-B27 typing available. HLA-B27-positive patients presented a male predominance, had an earlier disease onset and a shorter diagnostic delay compared with the negatives. HLA-B27-positive patients presented a higher frequency of axial involvement, radiographic sacroiliitis, enthesitis and uveitis. Also, root joint involvement, poliarticular joint patern and tarsitis were significantly higher within HLA-B27-positive patients. Furthermore, we did not observe any association between the presence of HLA-B27 and peripheral joint damage, dactylitis, other EMM (psoriasis, inflammatory bowel disease) or fibromyalgia.<\/jats:p>\n                  <jats:p>The multivariable analysis confirmed the independent association of HLA-B27 positivity with male sex, an earlier onset of the disease, the presence of axial involvement, tarsitis and uveitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary<\/jats:title>\n                  <jats:p>In summary, the presence of HLA-B27 in pSpA patients was associated with earlier disease onset and higher axial involvement, tarsitis and uveitis, but not with other EMM, fibromyalgia or peripheral structural damage.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2022-002696","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T09:16:29Z","timestamp":1670577389000},"page":"e002696","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Association between HLA-B27 and peripheral spondyloarthritis phenotype: results from the ASAS perSpA study"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-7494","authenticated-orcid":false,"given":"Marta","family":"Arevalo Salaet","sequence":"first","affiliation":[{"name":"Rheumatology Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Medicine Department, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-5837","authenticated-orcid":false,"given":"Clementina","family":"L\u00f3pez-Medina","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Cochin. Assistance Publique - H\u00f4pitaux de ParisINSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cit\u00e9, Universit\u00e9 de Paris, Paris, France"},{"name":"Rheumatology Department, Hospital Universitario Reina Sof\u00eda\/IMIBIC\/Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4365-4341","authenticated-orcid":false,"given":"Mireia","family":"Moreno","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Medicine Department, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Navarro-Compan","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario la Paz, IdiPaz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Calvet Fontova","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Medicine Department, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Llop","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Medicine Department, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-6229","authenticated-orcid":false,"given":"Maxime","family":"Dougados","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Cochin. Assistance Publique - H\u00f4pitaux de ParisINSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cit\u00e9, Universit\u00e9 de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Gratac\u00f3s","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed I3PT, Medicine Department, Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"2025090312454822000_8.2.e002696.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.133645"},{"key":"2025090312454822000_8.2.e002696.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108233"},{"key":"2025090312454822000_8.2.e002696.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91360-3"},{"key":"2025090312454822000_8.2.e002696.4","doi-asserted-by":"publisher","DOI":"10.1038\/242121a0"},{"key":"2025090312454822000_8.2.e002696.5","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.4049\/jimmunol.162.9.5045","article-title":"Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure","volume":"162","author":"Allen","year":"1999","journal-title":"J Immunol"},{"key":"2025090312454822000_8.2.e002696.6","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050596"},{"key":"2025090312454822000_8.2.e002696.7","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M116.066241"},{"key":"2025090312454822000_8.2.e002696.8","article-title":"Hla-B27, antigen presentation and ERAP1","volume":"32","author":"Bowness","year":"2014","journal-title":"Clinical and Experimental Rheumatology"},{"key":"2025090312454822000_8.2.e002696.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.07.013"},{"key":"2025090312454822000_8.2.e002696.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2018.07.012"},{"key":"2025090312454822000_8.2.e002696.11","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.2.348-369.2004"},{"key":"2025090312454822000_8.2.e002696.12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jbspin.2020.03.012","article-title":"Role of HLA-B27 in the comorbidities observed in axial spondyloarthritis: data from COMOSPA","volume":"87","author":"Ar\u00e9valo","year":"2020","journal-title":"Joint Bone Spine"},{"key":"2025090312454822000_8.2.e002696.13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13075-018-1724-7","article-title":"Influence of HLA-B27 on the ankylosing spondylitis phenotype: results from the REGISPONSER database","volume":"20","author":"Ar\u00e9valo","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"2025090312454822000_8.2.e002696.14","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-017-0654-8","article-title":"Ankylosing spondylitis: HLA-B*27-Positive versus HLA-B*27-Negative disease","volume":"19","author":"Akko\u00e7","year":"2017","journal-title":"Curr Rheumatol Rep"},{"key":"2025090312454822000_8.2.e002696.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0237-4"},{"key":"2025090312454822000_8.2.e002696.16","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780200401"},{"key":"2025090312454822000_8.2.e002696.17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.152975"},{"key":"2025090312454822000_8.2.e002696.18","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001450"},{"key":"2025090312454822000_8.2.e002696.19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.semarthrit.2021.04.018","article-title":"Unveiling axial involvement in psoriatic arthritis: an ancillary analysis of the ASAS-perSpA study","volume":"51","author":"Benavent","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"2025090312454822000_8.2.e002696.20","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/tan.12186","article-title":"Epidemiological comparison of clinical manifestations according to HLA-B*27 carrier status of Chinese ankylosing spondylitis patients","volume":"82","author":"Yang","year":"2013","journal-title":"Tissue Antigens"},{"key":"2025090312454822000_8.2.e002696.21","first-page":"111","article-title":"Linssen A. B27+ disease versus B27- disease","volume":"87","year":"1990","journal-title":"Scand J Rheumatol Suppl"},{"key":"2025090312454822000_8.2.e002696.22","doi-asserted-by":"publisher","DOI":"10.1002\/art.24483"},{"key":"2025090312454822000_8.2.e002696.23","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.semarthrit.2021.06.006","article-title":"Axial involvement in psoriatic arthritis: an update for rheumatologists","volume":"51","author":"Poddubnyy","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"2025090312454822000_8.2.e002696.24","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0074-2"},{"key":"2025090312454822000_8.2.e002696.25","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.091059"},{"key":"2025090312454822000_8.2.e002696.26","doi-asserted-by":"publisher","DOI":"10.1002\/art.38050"},{"key":"2025090312454822000_8.2.e002696.27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/rheumatology\/keab380","article-title":"Root joint involvement in spondyloarthritis: a post hoc analysis from the International ASAS-PerSpA study","volume":"61","author":"Ziad\u00e9","year":"2022","journal-title":"Rheumatology"},{"key":"2025090312454822000_8.2.e002696.28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.reuma.2015.11.008","article-title":"Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis","volume":"12","author":"Valls Pascual","year":"2016","journal-title":"Reumatol Clin"},{"key":"2025090312454822000_8.2.e002696.29","article-title":"Uveitis in peripheral spondyloarthritis patients: an ancillary analysis of the ASAS-PerSpA study","volume":"14:1759720X","author":"Llop","year":"2022","journal-title":"Ther Adv Musculoskelet Dis."},{"key":"2025090312454822000_8.2.e002696.30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.rdc.2020.01.009","article-title":"Axial psoriatic arthritis: a distinct clinical entity in search of a definition","volume":"46","author":"Michelena","year":"2020","journal-title":"Rheum Dis Clin North Am"},{"key":"2025090312454822000_8.2.e002696.31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fmed.2018.00290","article-title":"The impact of fibromyalgia in spondyloarthritis: from classification criteria to outcome measures","volume":"5","author":"Alunno","year":"2018","journal-title":"Front Med"}],"updated-by":[{"DOI":"10.1136\/rmdopen-2022-002696corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000}}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2022-002696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:45:55Z","timestamp":1756928755000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2022-002696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":31,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,12,9]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/rmdopen-2022-002696"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2022-002696","relation":{"correction":[{"id-type":"doi","id":"10.1136\/rmdopen-2022-002696corr1","asserted-by":"object"}]},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}