{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:40:12Z","timestamp":1792010412763,"version":"4.4.0"},"reference-count":17,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union Innovative Medicines Initiative 2 Joint Undertaking","award":["777357"],"award-info":[{"award-number":["777357"]}]},{"name":"European Union Innovative Medicines Initiative 2 Joint Undertaking","award":["831434"],"award-info":[{"award-number":["831434"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["387509280"],"award-info":[{"award-number":["387509280"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["394046635\u2013SFB"],"award-info":[{"award-number":["394046635\u2013SFB"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Me 3644\/8-1"],"award-info":[{"award-number":["Me 3644\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHR 771\/8-1"],"award-info":[{"award-number":["SCHR 771\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1350"],"award-info":[{"award-number":["SFB 1350"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,12,23]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    Treatment-refractory antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a life-threatening condition without evidence-based treatment options. One emerging treatment option for several antibody-mediated autoimmune diseases is the anti-CD38 antibody daratumumab, which depletes autoantibody-secreting plasma cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    We treated two patients with severe life-threatening AAV with renal and pulmonary manifestation despite induction therapy with rituximab and cyclophosphamide with four to eight doses of 1800\u2009mg daratumumab. We followed clinical and immunological responses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    The first patient with myeloperoxidase-ANCA-positive microscopic polyangiitis had resolution of pneumonitis and pleuritis and stabilisation of kidney function after daratumumab. The second patient with proteinase 3-ANCA-positive granulomatosis with polyangiitis, diffuse alveolar haemorrhage necessitating extracorporeal membrane oxygenation (ECMO) and acute kidney failure, requiring kidney replacement therapy, was weaned off ECMO, mechanical ventilation and dialysis and discharged home after daratumumab. Clinical improvement was paralleled by a strong reduction in serum ANCA levels as well as total IgG, indicating depletion of plasma cells. Apart from the depletion of CD38\n                    <jats:sup>+<\/jats:sup>\n                    natural killer cells, blood leucocyte levels were not notably influenced by daratumumab. Only mild adverse events, such as hypogammaglobulinaemia and an upper respiratory tract infection occurred.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    Daratumumab was safe and effective in inducing remission in two patients with severe treatment-refractory AAV, warranting prospective clinical trials to establish safety and efficacy.\n                  <\/jats:p>","DOI":"10.1136\/rmdopen-2022-002742","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T10:09:42Z","timestamp":1673345382000},"page":"e002742","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Daratumumab for the treatment of refractory ANCA-associated vasculitis"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-6406","authenticated-orcid":false,"given":"Lennard","family":"Ostendorf","sequence":"first","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Burns","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios Laurin","family":"Wagner","sequence":"additional","affiliation":[{"name":"BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health (BIH) at Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Berlin Center for Advanced Therapies (BeCAT), Charit\u00e9 - Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany"},{"name":"Institute of Transfusion Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Institute of Medical Immunology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Enghard","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[{"name":"Department of Nephropathology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Mei","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Seelow","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-6379","authenticated-orcid":false,"given":"Adrian","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Medical Intensive Care Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"Experimental and Clinical Research Center, Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC) and Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"2025090312142360000_9.1.e002742.1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-020-0204-y","article-title":"ANCA-associated vasculitis","volume":"6","author":"Kitching","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"2025090312142360000_9.1.e002742.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909905"},{"key":"2025090312142360000_9.1.e002742.3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.137778"},{"key":"2025090312142360000_9.1.e002742.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00601-6"},{"key":"2025090312142360000_9.1.e002742.5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-168286"},{"key":"2025090312142360000_9.1.e002742.6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206016"},{"key":"2025090312142360000_9.1.e002742.7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207947"},{"key":"2025090312142360000_9.1.e002742.8","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018020883"},{"key":"2025090312142360000_9.1.e002742.9","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1111\/ene.15266","article-title":"Daratumumab for treatment-refractory antibody-mediated diseases in neurology","volume":"29","author":"Scheibe","year":"2022","journal-title":"Eur J Neurol"},{"key":"2025090312142360000_9.1.e002742.10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153580","article-title":"High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura","volume":"132","author":"Canales-Herrerias","year":"2022","journal-title":"J Clin Invest"},{"key":"2025090312142360000_9.1.e002742.11","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1056\/NEJMoa2023325","article-title":"Targeting CD38 with Daratumumab in refractory systemic lupus erythematosus","volume":"383","author":"Ostendorf","year":"2020","journal-title":"N Engl J Med"},{"key":"2025090312142360000_9.1.e002742.12","doi-asserted-by":"crossref","first-page":"723758","DOI":"10.3389\/fmed.2022.723758","article-title":"Light chain restriction in proximal Tubules\u2014Implications for light chain proximal Tubulopathy","volume":"9","author":"B\u00fcttner-Herold","year":"2022","journal-title":"Front. 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