{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:57:33Z","timestamp":1793807853920,"version":"4.6.1"},"reference-count":14,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007273","name":"Weill Cornell Medical College","doi-asserted-by":"publisher","award":["Dean's Diversity Award"],"award-info":[{"award-number":["Dean's Diversity Award"]}],"id":[{"id":"10.13039\/100007273","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,12,12]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate and quantify the indicators of fetal and maternal morbidity in deliveries for patients with systemic lupus erythematosus (SLE) compared with deliveries in patients without SLE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used retrospective data from the National Inpatient Sample (NIS) to identify all delivery related hospital admissions of patients with and without SLE from 2008 to 2017 using ICD-9\/10 codes. Fetal morbidity indicators included pre-term delivery and intrauterine growth restriction (IUGR). 21 indicators of severe maternal morbidity were identified using standard Centers for Disease Control and Prevention (CDC) definitions. Descriptive statistics, including 95% confidence intervals, were calculated using sample weights from the NIS dataset.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 40\u2009million delivery-related admissions, 51\u2009161 patients were reported to have SLE. Patients with SLE had a higher risk of fetal morbidity, including IUGR (8.0% vs 2.7%) and pre-term delivery (14.5% vs 7.3%), than patients without SLE. During delivery, mothers with SLE were nearly four times as likely to require a blood transfusion or develop a cerebrovascular disorder, and 15 times as likely to develop acute renal failure than those without SLE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study demonstrates that fetal morbidity and severe maternal morbidity occur at a higher rate in patients with SLE compared with those without. This quantitative work can help inform and counsel patients with SLE during pregnancy and planning.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2022-002752","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T20:00:13Z","timestamp":1682452813000},"page":"e002752","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Fetal and maternal morbidity in pregnant patients with Lupus: a 10-year US nationwide analysis"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-0974","authenticated-orcid":false,"given":"Bella","family":"Mehta","sequence":"first","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna","family":"Jannat-Khah","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine Kayla","family":"Glaser","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Luo","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R","family":"Sammaritano","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D Ware","family":"Branch","sequence":"additional","affiliation":[{"name":"University of Utah Health, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1197-7864","authenticated-orcid":false,"given":"Susan M","family":"Goodman","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lockshin","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Northwell Health, New Hyde Park, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E","family":"Salmon","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery, New York, New York, USA"},{"name":"Weill Cornell Medicine, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"2025090312032718000_9.1.e002752.1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bpobgyn.2019.09.002","article-title":"Pregnancy and systemic lupus erythematosus","volume":"64","author":"Petri","year":"2020","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2025090312032718000_9.1.e002752.2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00240110"},{"key":"2025090312032718000_9.1.e002752.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.03.012"},{"key":"2025090312032718000_9.1.e002752.4","unstructured":"CDC . Severe maternal morbidity in the United States. reproductive health, 2021. Available: http:\/\/www.cdc.gov\/reproductivehealth\/maternalinfanthealth\/severematernalmorbidity.html"},{"key":"2025090312032718000_9.1.e002752.5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.7326\/M19-0120","article-title":"Trends in maternal and fetal outcomes among pregnant women with systemic lupus erythematosus in the United States: a cross-sectional analysis","volume":"171","author":"Mehta","year":"2019","journal-title":"Ann Intern Med"},{"key":"2025090312032718000_9.1.e002752.6","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3319"},{"key":"2025090312032718000_9.1.e002752.7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"2025090312032718000_9.1.e002752.8","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1001\/jama.2017.17653","article-title":"Adherence to methodological standards in research using the national inpatient sample","volume":"318","author":"Khera","year":"2017","journal-title":"JAMA"},{"key":"2025090312032718000_9.1.e002752.9","unstructured":"HCUP. AHRQ . Trend weights for HCUP NIS data, 2021. Available: www.hcup-us.ahrq.gov\/db\/nation\/nis\/trend-wghts.jsp"},{"key":"2025090312032718000_9.1.e002752.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.01.002"},{"key":"2025090312032718000_9.1.e002752.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209770"},{"key":"2025090312032718000_9.1.e002752.12","first-page":"1","article-title":"Trends in out-of-hospital births in the United States, 1990-2012","author":"MacDorman","year":"2014","journal-title":"NCHS Data Brief"},{"key":"2025090312032718000_9.1.e002752.13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-020-2139-9","article-title":"Low frequency of flares during pregnancy and post-partum in stable lupus patients","volume":"22","author":"Davis-Porada","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2025090312032718000_9.1.e002752.14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/acr2.11147","article-title":"Impact of a multifaceted educational program to improve provider skills for lupus pregnancy planning and management: a mixed-methods approach","volume":"2","author":"Njagu","year":"2020","journal-title":"ACR Open Rheumatol"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2022-002752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:03:32Z","timestamp":1756926212000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2022-002752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,4,25]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/rmdopen-2022-002752"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2022-002752","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}