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Chronic exposure to air pollution has been associated with a number of detrimental effects on the immune system, including direct activation of autoimmunity and autoantibodies production. Rheumatoid arthritis (RA) is a paradigmatic example of the link between environmental stimuli and development of autoimmunity. Recent evidence has confirmed such association and provided further indication of the strict relationship between the lungs and the synovial tissue. Hard rock mining and chronic exposure to airborne fine particulate matter have been associated with higher risk of developing RA. In addition, new evidence showed a peculiar association between acute exposure to toxic inhalants and risk of RA flare. In conclusion, the environment is the straw that breaks the camel's back, unfortunately the \u201cstraws\u201d are rapidly accumulating, and their burden is projected to increase accordingly.<\/jats:p>","DOI":"10.1136\/rmdopen-2022-002807","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T10:36:21Z","timestamp":1670841381000},"page":"e002807","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Mining the pathogenesis of rheumatoid arthritis, the leading role of the environment"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8915-0755","authenticated-orcid":false,"given":"Giovanni","family":"Adami","sequence":"first","affiliation":[{"name":"Medicine, Rheumatology Unit, Universita degli Studi di Verona Scuola di Medicina e Chirurgia, Verona, 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