{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:04:23Z","timestamp":1776747863838,"version":"3.51.2"},"reference-count":40,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010767","name":"Stiftung f\u00fcr die Erforschung der Muskelkrankheiten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010767","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2022,12,23]]},"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To characterise factors associated with permanent vision loss (PVL) and potential reasons for the therapeutic delay contributing to PVL in giant cell arteritis (GCA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective analysis of GCA patients diagnosed at the University Hospital Basel between December 2006 and May 2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 282 patients with GCA (64% females), 49 (17.4%) experienced PVL. In 43\/49 (87.8%) PVL occurred before treatment. Of these, 24 (55.8%) patients had first non-ocular symptoms and eventually sought consultation when PVL occurred in a median of 21 (IQR 14.75\u201331.0)\u2009days after the first symptoms. Only five of the 24 patients had consulted a physician before PVL, but GCA diagnosis was missed. Treatment was initiated rapidly after diagnosis (median 1\u2009day (IQR 0.0\u20137.0)). PVL on therapy occurred in six patients in a median of 40 (IQR 20.5\u201367.3)\u2009days after treatment started. In two of those, glucocorticoids were tapered too quickly.<\/jats:p>\n                  <jats:p>In multivariable analysis, patients with PVL were older (OR 1.17, 95%\u2009CI 1.07 to 1.29, p=0.001) and reported more frequently jaw claudication (OR 3.52, 95%\u2009CI 1.02 to 13.16, p=0.051). PVL was present in 18 (42.9%) of the 42 patients with vasculitic ultrasound findings in all six temporal artery segments. The incidence of PVL over 15 years did not decline (Spearman rank=0.3, p=0.68).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of GCA-associated PVL remains high. Associated factors were advanced age, jaw claudication and ultrasound findings consistent with vasculitis in all six temporal artery segments. Despite preceding non-ocular GCA symptoms weeks before the onset of PVL, most patients were not seen by a rheumatologist before PVL occurred.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2022-002866","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T09:50:04Z","timestamp":1673517004000},"page":"e002866","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Long delay from symptom onset to first consultation contributes to permanent vision loss in patients with giant cell arteritis: a cohort study"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-5409","authenticated-orcid":false,"given":"Andrea Katharina","family":"Hemmig","sequence":"first","affiliation":[{"name":"Department of Rheumatology, University Hospital Basel, Basel, 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