{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:39:03Z","timestamp":1787017143252,"version":"build-2736575974"},"reference-count":37,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2023,5,19]]},"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To conduct a systematic review of the literature on the association between fibromyalgia and mortality and to pool the results in a meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors searched the PubMed, Scopus, and Web of Science databases using the key words \u2018fibromyalgia\u2019 and \u2018mortality\u2019 to identify studies that addressed an association between fibromyalgia and mortality. Original papers that assessed associations between fibromyalgia and mortality (all or specific causes) and provided an effect measure (hazard ratio (HR), standardised mortality ratio (SMR), odds ratio (OR)) quantifying the relationship between fibromyalgia and mortality were included in the systematic review. Of 557 papers that were initially identified using the search words, 8 papers were considered eligible for the systematic review and meta-analysis. We used a Newcastle-Ottawa scale to assess the risk of bias in the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total fibromyalgia group included 188\u2009751 patients. An increased HR was found for all-cause mortality (HR 1.27, 95%\u2009CI 1.04 to 1.51), but not for the subgroup diagnosed by the 1990 criteria. There was a borderline increased SMR for accidents (SMR 1.95, 95%\u2009CI 0.97 to 3.92), an increased risk for mortality from infections (SMR 1.66, 95%\u2009CI 1.15 to 2.38), and suicide (SMR 3.37, 95%\u2009CI 1.52 to 7.50), and a decreased mortality rate for cancer (SMR 0.82, 95%\u2009CI 0.69 to 0.97). The studies showed significant heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These potential associations indicate that fibromyalgia should be taken seriously, with a special focus on screening for suicidal ideation, accident prevention, and the prevention and treatment of infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003005","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T06:55:10Z","timestamp":1690786510000},"page":"e003005","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Fibromyalgia and mortality: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-713X","authenticated-orcid":false,"given":"Yulia","family":"Treister-Goltzman","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Clalit Health Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Peleg","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"},{"name":"Clalit Health Services, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"2025090313272665000_9.3.e003005.1","doi-asserted-by":"crossref","DOI":"10.1177\/21501319221094169","article-title":"Prevalence and incidence of patients with fibromyalgia in Catalonia between 2010 and 2017: a descriptive observational study","volume":"13","author":"Sauch Valma\u00f1a","year":"2022","journal-title":"J Prim Care Community Health"},{"key":"2025090313272665000_9.3.e003005.2","doi-asserted-by":"publisher","DOI":"10.1177\/0141076817702530"},{"key":"2025090313272665000_9.3.e003005.3","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"2025090313272665000_9.3.e003005.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"2025090313272665000_9.3.e003005.5","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041219","article-title":"Diagnostic criteria for fibromyalgia: critical review and future perspectives","volume":"9","author":"Galvez-S\u00e1nchez","year":"2020","journal-title":"J Clin Med"},{"key":"2025090313272665000_9.3.e003005.6","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-007-0214-4"},{"key":"2025090313272665000_9.3.e003005.7","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/ejp.1252","article-title":"Comorbid fibromyalgia: a qualitative review of prevalence and importance","volume":"22","author":"Fitzcharles","year":"2018","journal-title":"Eur J Pain"},{"key":"2025090313272665000_9.3.e003005.8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/BOR.0000000000000464","article-title":"The complexities of fibromyalgia and its comorbidities","volume":"30","author":"Lichtenstein","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"2025090313272665000_9.3.e003005.9","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190149"},{"key":"2025090313272665000_9.3.e003005.10","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1177\/0890117119854041","article-title":"Chronic pain, physical activity, and all-cause mortality in the US adults: the NHANES 1999-2004 follow-up study","volume":"33","author":"Kim","year":"2019","journal-title":"Am J Health Promot"},{"key":"2025090313272665000_9.3.e003005.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211476"},{"key":"2025090313272665000_9.3.e003005.12","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/pm\/pnab287","article-title":"Pain conditions and suicide attempts in military veterans: a case-control design","volume":"22","author":"Boska","year":"2021","journal-title":"Pain Med"},{"key":"2025090313272665000_9.3.e003005.13","unstructured":"Wells GA , Shea B , O\u2019\u2019Connell D , et al . 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