{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:56:14Z","timestamp":1788782174947,"version":"build-2803163510"},"reference-count":20,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2023,8,2]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe primary Sj\u00f6gren\u2019s disease (SjD) patients presenting no or low level of dryness and to compare them with SjD patients with oral or ocular dryness features.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All patients diagnosed with SjD according to AECG or ACR\/EULAR criteria in our tertiary reference centre were included. Patients with high or low subjective symptoms or objective signs of dryness were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 509 patients were included for the comparison of patients with high (n=456) or low (n=53) level of subjective dryness and 472 for the comparison of patients with (n=359) or without (n=113) high objective dryness. Compared with patients with subjective dryness, patients without high subjective dryness were significantly younger (median 49 (39\u201362) years vs 58 (47\u201367) years, p&lt;0.01), diagnosed earlier (median time from first symptoms to diagnosis 2 (0.5\u20134.5) years vs 4 (1\u20139.25), p=0.0056), more frequently anti-SSA positive ((83% vs 64%, p=0.008) and had less focal sialadenitis in minor salivary gland biopsy (69% vs 83%, p=0.02).<\/jats:p>\n                  <jats:p>The patients without high level of objective dryness (n=113) were also younger (51 (41\u201360) vs 58 (47\u201367) years, p&lt;0.001) and were more frequently anti-SSA positive (79% vs 63%, p=0.002).<\/jats:p>\n                  <jats:p>In both groups, no difference was observed regarding disease activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among the patients with SjD, those without high subjective or objective dryness features had a younger profile, a faster diagnosis which may result from a more acute onset, were more frequently anti-SSA positive than patients with high dryness features.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003291","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T21:16:40Z","timestamp":1698614200000},"page":"e003291","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison between primary Sj\u00f6gren\u2019s disease patients with high or low level of dryness"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-7539","authenticated-orcid":false,"given":"Alexandra","family":"Kachaner","sequence":"first","affiliation":[{"name":"Faculty of medicine, Paris Cit\u00e9 Universit\u00e9, Paris, France"},{"name":"Department of Rheumatology, Universit\u00e9 Paris-Saclay, INSERM UMR1184: Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Berg\u00e9","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Universit\u00e9 Paris-Saclay, INSERM UMR1184: Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Desmoulins","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Universit\u00e9 Paris-Saclay, INSERM UMR1184: Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Le Pajolec","sequence":"additional","affiliation":[{"name":"Department of ENT, Universit\u00e9 Paris-Saclay, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universit\u00e9 Paris-Saclay, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bicetre, Le Kremlin-Bicetre, France"},{"name":"Immunology of Viral Infections and Autoimmune, Hematological and Bacterial Diseases, Inserm U1184, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Labetoulle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Universit\u00e9 Paris-Saclay, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bicetre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-0733","authenticated-orcid":false,"given":"Ga\u00e9tane","family":"Nocturne","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Universit\u00e9 Paris-Saclay, INSERM UMR1184: Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-5417","authenticated-orcid":false,"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Universit\u00e9 Paris-Saclay, INSERM UMR1184: Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, 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