{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:34:07Z","timestamp":1790030047966,"version":"4.0.1"},"reference-count":25,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2023,8,3]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the impact of ultrasound (US) intrinsic limitation to assess aortitis versus FDG-PET\/CT in patients with US-proven giant cell arteritis (GCA) and to identify factors associated with aortic involvement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective observational study of patients referred to US fast-track clinics at two academic centres over a 4-year period. Only patients with GCA confirmed by US were included. Temporal arteries (TA) and extracranial arteries US were performed at baseline. FDG-PET\/CT was performed according to clinician\u2019s criteria. An FDG artery uptake at the aorta higher than liver uptake was considered positive for aortitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-two of 186 patients with US-proven GCA underwent an FDG-PET\/CT; 29 (40.3%) had a positive FDG-PET\/CT and 24 (33.3%) presented aortitis. Only 6 (20.7%) patients with positive FDG-PET\/CT had negative US findings of large vessel (LV)-GCA. Among patients with aortitis in FDG-PET\/CT, only two (8.3%) had negative US findings of LV-GCA. Patients with aortitis were younger (68.9 vs 81;p&lt;0.001), more frequently females (79.2% vs 39.6%;p=0.002) and had higher platelets count (413.4 vs 311.1;p=0014). Patients with aortitis presented positive TA US less frequently (41.7% vs 83.3%;p&lt;0.001), but more LV US involvement (91.7% vs 41.7%; p&lt;0.001) versus patients without aortitis. None of the patients with aortitis exhibited visual symptoms (0% vs 31.2%;p=0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FDG-PET\/CT can detect aortitis in one out of every three patients with US-proven GCA. However, a negative US examination for LV-GCA suggests a low risk of aortitis. Younger and female GCA patients with thrombocytosis, absence of visual manifestations and LV-GCA on US may more frequently present aortitis by FDG-PET\/CT.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003329","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:55:43Z","timestamp":1692431743000},"page":"e003329","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of ultrasound limitation to assess aortitis in patients with giant cell arteritis: comparative study with FDG-PET\/CT"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-7802","authenticated-orcid":false,"given":"Juan","family":"Molina-Collada","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Castrej\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"},{"name":"Faculty of Medicine. Complutense University of Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-8016","authenticated-orcid":false,"given":"Irene","family":"Monjo-Henry","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-5042","authenticated-orcid":false,"given":"Elisa","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Torres Ortiz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mart\u00ednez-Barrio","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"\u00c1lvaro-Gracia","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n (IiSGM), Madrid, Spain"},{"name":"Faculty of Medicine. 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