{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:53:21Z","timestamp":1790142801067,"version":"4.0.1"},"reference-count":41,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Observational case\u2013control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. NLP was used to extract unstructured clinical information from EHR and standardise it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis was performed. Characteristics between patients with RAILD and RA patients without ILD (RAnonILD) were compared.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From a source population of 3 176 165 patients and 64\u2009241\u2009683 EHRs, 13 958 patients with RA were identified. Of those, 5.1% patients additionally had ILD (RAILD). The overall age-adjusted prevalence of RA and RAILD were 0.53% and 0.02%, respectively. The most common ILD subtype was usual interstitial pneumonia (29.3%). When comparing RAILD versus RAnonILD patients, RAILD patients were older and had more comorbidities, notably concerning infections (33.6% vs 16.5%, p&lt;0.001), malignancies (15.9% vs 8.5%, p&lt;0.001) and cardiovascular disease (25.8% vs 13.9%, p&lt;0.001) than RAnonILD. RAILD patients also had higher inflammatory burden reflected in more pharmacological prescriptions and higher inflammatory parameters and presented a higher in-hospital mortality with a higher risk of death (HR 2.32; 95%\u2009CI 1.59 to 2.81, p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD patients were more vulnerable at the time of inclusion with higher comorbidity and inflammatory burden than RAnonILD, which correlated with higher mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003353","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T23:15:42Z","timestamp":1706656542000},"page":"e003353","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning"],"prefix":"10.1136","volume":"10","author":[{"given":"Jose A","family":"Rom\u00e1n Ivorra","sequence":"first","affiliation":[{"name":"Reumathology Department, Hospital Polit\u00e9cnico y Universitario La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Trallero-Araguas","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lopez Lasanta","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cebri\u00e1n","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Infanta Leonor, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Lojo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Infanta Leonor, Madrid, 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Cabello","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Central de la Defensa G\u00f3mez Ulla, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Ahijado","sequence":"additional","affiliation":[{"name":"Rheumatology, Hospital Universitario Fuenlabrada, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"De la Morena Barrio","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Costas Torrijo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Cl\u00ednico Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Safont","sequence":"additional","affiliation":[{"name":"Pneumology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ornilla","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Cl\u00ednica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Campo","sequence":"additional","affiliation":[{"name":"Pneumology Department, Clinica Universidad de Navarra, Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Andreu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Complejo Asistencial Universitario de Leon, Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"L\u00f3pez Robles","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Complejo Asistencial Universitario de Leon, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bollo","sequence":"additional","affiliation":[{"name":"Pneumology Department, Complejo Asistencial Universitario de Leon, Leon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Benavent","sequence":"additional","affiliation":[{"name":"Medical Department, Savana Research SL, Madrid, 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