{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T17:25:49Z","timestamp":1757611549283,"version":"3.44.0"},"reference-count":32,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ETH Foundation","award":["SEED-19 20-1"],"award-info":[{"award-number":["SEED-19 20-1"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2023,9,6]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Treatment response is worse in obese patients with rheumatoid arthritis (RA), including patients on weight-adjusted therapies like infliximab. We aimed to assess the association between body mass index (BMI) and changes in RA disease activity and radiographic progression over time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included infliximab users with an RA diagnosis in the Swiss Clinical Quality Management in Rheumatic Diseases registry (1997\u20132020). Two cohorts were defined: (1) starting from their first BMI measurement or disease activity score (DAS28-esr), and (2) from their first BMI measurement or radiographic assessment (Rau score). We evaluated the coefficient and 95% CI of BMI with changes in mean DAS28-esr (cohort 1) and mean Rau scores (a structural joint damage score, cohort 2) using generalised estimation equations, overall and stratified by BMI categories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Cohort 1 comprised 412 patients (74%\u2009women, mean age 53 years, mean BMI 25). We observed no change in mean DAS28-esr with increasing BMI overall (adjusted coefficient: 0.00, 95%\u2009CI \u22120.02 to 0.02), or in BMI categories. Cohort 2 comprised 187 patients highly alike to those in cohort 1. We observed a significant decrease of 1.05 in mean Rau scores for every increase in BMI unit (adjusted coefficient: \u22121.05, 95%\u2009CI \u22121.92 to \u22120.19). Results remained statistically non-significant across BMI categories.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our longitudinal investigation suggests that BMI increase may not lead to changes in DAS28-esr in patients receiving infliximab, despite the weight-adapted dose. Yet, there may be a decrease in erosions with increasing weight non-limited to obese patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003396","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T11:47:07Z","timestamp":1707479227000},"page":"e003396","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal associations between body mass index and changes in disease activity and radiographic progression in rheumatoid arthritis patients treated with infliximab"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1313-4473","authenticated-orcid":false,"given":"Theresa","family":"Burkard","sequence":"first","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, Eidgenossische Technische Hochschule Z\u00fcrich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enriqueta","family":"Vallejo-Yag\u00fce","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, Eidgenossische Technische Hochschule Z\u00fcrich, Zurich, Switzerland"},{"name":"University of Bern, Institute of Primary Health Care (BIHAM), Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4315-9009","authenticated-orcid":false,"given":"Kim","family":"Lauper","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-4347","authenticated-orcid":false,"given":"Axel","family":"Finckh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Geneva, Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3276-9581","authenticated-orcid":false,"given":"Thomas","family":"H\u00fcgle","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea M","family":"Burden","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, Eidgenossische Technische Hochschule Z\u00fcrich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"2025090313481947000_9.4.e003396.1","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2025090313481947000_9.4.e003396.2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217344"},{"key":"2025090313481947000_9.4.e003396.3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10143194","article-title":"Comparison of Psoriatic arthritis and rheumatoid arthritis patients across body mass index categories in Switzerland","volume":"10","author":"Vallejo-Yag\u00fce","year":"2021","journal-title":"J Clin Med"},{"key":"2025090313481947000_9.4.e003396.4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker349"},{"key":"2025090313481947000_9.4.e003396.5","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103357","article-title":"Effect of body mass index on treatment response of biologic\/targeted-synthetic Dmards in patients with rheumatoid arthritis, Psoriatic arthritis or axial Spondyloarthritis. 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