{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:05:34Z","timestamp":1788570334292,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2023,11,8]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Still\u2019s disease is more frequently observed in the paediatric context, but a delayed onset is not exceptional both in the adulthood and in the elderly. However, whether paediatric-onset, adult-onset and elderly-onset Still\u2019s disease represent expressions of the same disease continuum or different clinical entities is still a matter of controversy. The aim of this study is to search for any differences in demographic, clinical features and response to treatment between pediatric-onset, adult-onset and elderly-onset Still\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Subjects included in this study were drawn from the International AutoInflammatory Disease Alliance Network registry for patients with Still\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 411 patients suffering from Still\u2019s disease were enrolled; the disease occurred in the childhood in 65 (15.8%) patients, in the adult 314 (76.4%) patients and in the elderly in 32 (7.8%) patients. No statistically significant differences at post-hoc analysis were observed in demographic features of the disease between pediatric-onset, adult-onset and elderly-onset Still\u2019s disease. The salmon-coloured skin rash (p=0.004), arthritis (p=0.009) and abdominal pain (p=0.007) resulted significantly more frequent among paediatric patients than in adult cases, while pleuritis (p=0.015) and arthralgia (p&lt;0.0001) were significantly more frequent among elderly-onset patients compared with paediatric-onset subjects. Regarding laboratory data, thrombocytosis was significantly more frequent among paediatric patients onset compared with adult-onset subjects (p&lt;0.0001), while thrombocytopenia was more frequent among elderly-onset patients although statistical significance was only bordered. No substantial differences were observed in the response to treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite some minor difference between groups, overall, demographic, clinical, laboratory and treatments aspects of Still\u2019s disease were similarly observed in patients at all ages. This supports that pediatric-onset, adult-onset and elderly-onset Still\u2019s disease is the same clinical condition arising in different ages.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003578","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T12:22:24Z","timestamp":1701433344000},"page":"e003578","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Still\u2019s disease continuum from childhood to elderly: data from the international AIDA Network Still\u2019s disease registry"],"prefix":"10.1136","volume":"9","author":[{"given":"Antonio","family":"Vitale","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Beh\u00e7et's Disease Clinic, University of Siena, Siena, Italy"},{"name":"Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caggiano","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Beh\u00e7et's Disease Clinic, University of Siena, Siena, Italy"},{"name":"Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Azienda Ospedaliero-Universitaria Senese, Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[{"name":"Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-0882","authenticated-orcid":false,"given":"Henrique A","family":"Mayrink Giardini","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina, Hospital das Cl\u00ednicas, Universidade de Sao Paulo, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-1264","authenticated-orcid":false,"given":"Francesco","family":"Ciccia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A","family":"Almaghlouth","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia"},{"name":"College of Medicine Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3487-8551","authenticated-orcid":false,"given":"Piero","family":"Ruscitti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, Universit\u00e0 degli Studi dell'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P","family":"Sfikakis","sequence":"additional","affiliation":[{"name":"Joint Academic Rheumatology Program, Medical School, National and Kapodistrian, University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6244-9362","authenticated-orcid":false,"given":"Abdurrahman","family":"Tufan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Gazi University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-315X","authenticated-orcid":false,"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"Division of Immunology, Transplants and Infectious Diseases, Universit\u00e0 Vita-Salute San Raffaele, Milan, Italy"},{"name":"Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Rome, Italy"},{"name":"Rheumatology, Immunology and Clinical Medicine Unit, Department of Medicine, University of Rome \u201cCampus Biomedico\u201d School of Medicine, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hinojosa-Azaola","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gafaar","family":"Ragab","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Cairo University, Giza, Egypt"},{"name":"Faculty of Medicine, Newgiza University, 6th of October City, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2598-5806","authenticated-orcid":false,"given":"Haner","family":"Direskeneli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, 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