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Consequently, management of refractory and chronic gout has been gaining attention. Onset of gout is related to the deposition of monosodium urate crystals under hyperuricaemia. Interestingly, acute gout attacks often resolve spontaneously within 7\u201310 days, and many studies have confirmed the notion that gout flares can be self-relieved. However, the underlying mechanism for spontaneous remission of gout requires further elucidation. In this article, we summarise the roles and mechanisms related to spontaneous remission of gout, which are essential for understanding its pathogenesis and developing potential targeted therapies.<\/jats:p>","DOI":"10.1136\/rmdopen-2023-003586","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T12:35:38Z","timestamp":1695299738000},"page":"e003586","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Spontaneous resolution of acute gout: mechanisms and therapeutic targets"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1739-3056","authenticated-orcid":false,"given":"Meiling","family":"Shi","sequence":"first","affiliation":[{"name":"Medical College of Nanchang University, Nanchang, China"},{"name":"Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 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