{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:30:43Z","timestamp":1791387043693,"version":"4.3.3"},"reference-count":26,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2019M3A9A8065574"],"award-info":[{"award-number":["2019M3A9A8065574"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korea government","award":["NRF-2022R1A2C2091831"],"award-info":[{"award-number":["NRF-2022R1A2C2091831"]}]},{"name":"Small Grant Program"},{"name":"New Investigators","award":["R03 DE030990"],"award-info":[{"award-number":["R03 DE030990"]}]},{"name":"PHS","award":["U01 DE017593"],"award-info":[{"award-number":["U01 DE017593"]}]},{"name":"The Danish Dental Association"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,3,4]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is the second most common chronic autoimmune connective tissue disease. Autoantibodies, immunoglobulin (IgG) anti-SSA\/Ro, in serum is a key diagnostic feature of pSS. Since pSS is a disease of the salivary gland, we investigated anti-SSA\/Ro52 in saliva.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a novel electrochemical detection platform, Electric Field-Induced Release and Measurement, we measured IgG\/M\/A, IgG, IgA, IgA isotypes (IgA1 and IgA2) and IgA1 subclasses (polymeric and monomeric IgA1) to anti-SSA\/Ro52 in saliva supernatant of 34 pSS, 35 dry eyes and dry mouth (patients with Sicca) and 41 health controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Saliva IgG\/M\/A, IgG, IgA, IgA isotypes and IgA1 subclasses to anti-SSA\/Ro52 differed significantly between pSS, non-pSS Sicca and healthy subjects. Elevated monomeric IgA1 was observed in patients with non-pSS Sicca while elevated polymeric IgA1 (pIgA1) was observed in patients with pSS. Salivary polymeric but not monomeric IgA1 (mIgA1) isoform correlated with focus score (r2=0.467, p=0.001)<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salivary anti-Ro52 polymeric IgA1 isoform is associated with glandular inflammation in pSS, while salivary monomeric IgA1 is associated with Sicca. Whether IgA1 isotope switching plays a role in the progression of the Sicca to pSS warrants further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003666","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:26:19Z","timestamp":1712755579000},"page":"e003666","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Distinctive profile of monomeric and polymeric anti-SSA\/Ro52 immunoglobulin A1 isoforms in saliva of patients with primary Sj\u00f6gren\u2019s syndrome and Sicca"],"prefix":"10.1136","volume":"10","author":[{"given":"Samantha","family":"Chiang","sequence":"first","affiliation":[{"name":"UCLA School of Dentistry, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Grogan","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, University of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Kyun Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Akin","sequence":"additional","affiliation":[{"name":"UCLA School of Dentistry, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Elashoff","sequence":"additional","affiliation":[{"name":"Department of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie Lynge","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Section for Oral Biolology and Immunopathology, Oral Medicine and Pathology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-3437","authenticated-orcid":false,"given":"Yeong Wook","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T W","family":"Wong","sequence":"additional","affiliation":[{"name":"UCLA School of Dentistry, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0723-3670","authenticated-orcid":false,"given":"David","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, 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