{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:14:37Z","timestamp":1790907277003,"version":"4.1.0"},"reference-count":24,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Canada Research Chair (Tier 2) in Inflammatory Rheumatic Diseases","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"AbbVie Fellowship","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,9,24]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the association between musculoskeletal sonographic features and clinical features, as well as treatment outcomes, in patients with active psoriatic arthritis (PsA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective cohort study was conducted involving patients with active PsA. Disease activity was assessed clinically at baseline and 3\u20136 months after initiating therapy, with a Disease Activity Index for PsA (DAPSA) score calculated. A baseline ultrasound examination of 64 joints, 28 tendons and 16 entheses evaluated the following lesions: synovitis, peritenonitis, enthesitis, tenosynovitis, new bone formation and erosions. Total scores for each lesion and total inflammatory and structural scores were calculated. The association between baseline sonographic scores and treatment outcomes was assessed using Cox proportional hazards models (for drug persistence) and generalised estimating equation models for DAPSA change.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 135 treatment periods (107 patients) were analysed. Multivariable analysis showed that a greater reduction in DAPSA score at follow-up was associated with higher baseline synovitis (\u03b2 \u22123.89), peritenonitis (\u03b2 \u22123.93) and enthesitis structural scores (\u03b2 \u22122.91). Additionally, the total inflammatory score independently predicted DAPSA change (\u03b2 \u22125.23) regardless of the total structural damage score. Drug persistence was analysed in 105 treatment periods, revealing that a higher sonographic erosion score was associated with earlier drug discontinuation (adjusted HR 1.28, 95% CI 1.03 to 1.61).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The study results provide preliminary evidence supporting the utility of musculoskeletal ultrasound in predicting treatment response and drug persistence in PsA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2023-003995","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:37:30Z","timestamp":1730288250000},"page":"e003995","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association between musculoskeletal sonographic features and response to treatment in patients with psoriatic arthritis"],"prefix":"10.1136","volume":"10","author":[{"given":"Jessica","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Rheumatology, Women's College Hospital, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Thib","sequence":"additional","affiliation":[{"name":"Rheumatology, Women's College Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Koppikar","sequence":"additional","affiliation":[{"name":"Rheumatology, Women's College Hospital, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-1715","authenticated-orcid":false,"given":"Lihi","family":"Eder","sequence":"additional","affiliation":[{"name":"Rheumatology, Women's College Hospital, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"2025090312104398000_10.4.e003995.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-203073"},{"key":"2025090312104398000_10.4.e003995.2","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/acr.20627","article-title":"Cardiovascular and other comorbidities in patients with psoriatic arthritis: a comparison with patients with psoriasis","volume":"63","author":"Husted","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2025090312104398000_10.4.e003995.3","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1093\/rheumatology\/keac078","article-title":"Defining imaging sub-phenotypes of psoriatic arthritis: integrative analysis of imaging data and gene expression in a PsA patient cohort","volume":"61","author":"Eder","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"2025090312104398000_10.4.e003995.4","doi-asserted-by":"crossref","first-page":"101690","DOI":"10.1016\/j.berh.2021.101690","article-title":"Imaging in psoriatic arthritis: Status and recent advances","volume":"35","author":"Mathew","year":"2021","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025090312104398000_10.4.e003995.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1292-y"},{"key":"2025090312104398000_10.4.e003995.6","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206971"},{"key":"2025090312104398000_10.4.e003995.7","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.210974"},{"key":"2025090312104398000_10.4.e003995.8","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-017-1399-5","article-title":"The association between sonographic enthesitis and radiographic damage in psoriatic arthritis","volume":"19","author":"Polachek","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"2025090312104398000_10.4.e003995.9","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/1756-185X.14122","article-title":"Enthesis lesions are associated with X-ray progression in psoriatic arthritis","volume":"24","author":"Mac\u00eda-Villa","year":"2021","journal-title":"Int J Rheum Dis"},{"key":"2025090312104398000_10.4.e003995.10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/rheumatology\/kead202","article-title":"The association between sonographic enthesitis with sonographic synovitis and tenosynovitis in psoriatic arthritis patients","volume":"63","author":"Balulu","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"2025090312104398000_10.4.e003995.11","doi-asserted-by":"crossref","unstructured":"Macchioni P , Marchesoni A , Ciancio G , et al . n.d. Residual inflammation in psoriatic arthritis patients in stable minimal disease activity. Front Med 9:1096547. doi:10.3389\/fmed.2022.1096547","DOI":"10.3389\/fmed.2022.1096547"},{"key":"2025090312104398000_10.4.e003995.12","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/rheumatology\/keab628","article-title":"Response to secukinumab on synovitis using Power Doppler ultrasound in psoriatic arthritis: 12-week results from a phase III study, ULTIMATE","volume":"61","author":"D\u2019Agostino","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"2025090312104398000_10.4.e003995.13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/jcm10132834","article-title":"In Patients with Early Peripheral Psoriatic Arthritis Baseline C-Reactive Protein, Pain and Ultrasound-Detected Synovitis Predict Subsequent Treatment with ts\/bDMARDs. A Retrospective Analysis","volume":"10","author":"Sakellariou","year":"2021","journal-title":"J Clin Med"},{"key":"2025090312104398000_10.4.e003995.14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/rheumatology\/keq262","article-title":"Observational cohort studies: lessons learnt from the University of Toronto Psoriatic Arthritis Program","volume":"50","author":"Gladman","year":"2011","journal-title":"Rheumatology (Sunnyvale)"},{"key":"2025090312104398000_10.4.e003995.15","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"},{"key":"2025090312104398000_10.4.e003995.16","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000428","article-title":"Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 1: definition and development of a standardised, consensus-based scoring system","volume":"3","author":"D\u2019Agostino","year":"2017","journal-title":"RMD Open"},{"key":"2025090312104398000_10.4.e003995.17","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.147272"},{"key":"2025090312104398000_10.4.e003995.18","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202092"},{"key":"2025090312104398000_10.4.e003995.19","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/acr.22191","article-title":"Defining Enthesitis in Spondyloarthritis by Ultrasound: Results of a Delphi Process and of a Reliability Reading Exercise","volume":"66","author":"Terslev","year":"2014","journal-title":"Arthritis Care & Research"},{"key":"2025090312104398000_10.4.e003995.20","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171465"},{"key":"2025090312104398000_10.4.e003995.21","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.180856"},{"key":"2025090312104398000_10.4.e003995.22","doi-asserted-by":"crossref","DOI":"10.1093\/rap\/rkab086","article-title":"Ultrasound shows swollen joints are the better proxy for synovitis than tender joints in DMARD-na\u00efve early psoriatic arthritis","volume":"5","author":"Dubash","year":"2021","journal-title":"Rheumatol Adv Pract"},{"key":"2025090312104398000_10.4.e003995.23","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161347"},{"key":"2025090312104398000_10.4.e003995.24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.11152\/mu-1266","article-title":"Could nail and joint alterations make the difference between psoriatic arthritis and osteoarthritis during the ultrasonographic evaluation of the distal interphalangeal joints?","volume":"19","author":"Batticciotto","year":"2017","journal-title":"Med Ultrason"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2023-003995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:10:56Z","timestamp":1756926656000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2023-003995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,10,30]]},"published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1136\/rmdopen-2023-003995"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2023-003995","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]}}}