{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:42:28Z","timestamp":1793418148878,"version":"4.5.0"},"reference-count":41,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"unspecified","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000033","name":"Institute of Musculoskeletal Health and Arthritis","doi-asserted-by":"publisher","award":["MOP-115068"],"award-info":[{"award-number":["MOP-115068"]}],"id":[{"id":"10.13039\/501100000033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000142","name":"Arthritis Society","doi-asserted-by":"publisher","award":["19\u20130469"],"award-info":[{"award-number":["19\u20130469"]}],"id":[{"id":"10.13039\/501100000142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,4,14]]},"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of our study was to characterise spatiotemporal features of disease progression in people with diffuse idiopathic skeletal hyperostosis (DISH), early-phase DISH, and those not meeting either criterion who had repeated CT scans of the thoracic spine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective study was designed in collaboration with the\n                      <jats:italic>Rochester Epidemiology Project<\/jats:italic>\n                      to evaluate completeness of ectopic bridging across the thoracic spine and corresponding disease status over an average of 2.7 years (range from 0.2 to 15.0 years) in a cohort of 83 female and 74 male individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 15% of individuals displayed changes in imaging features over time that resulted in a revised diagnosis along the continuum of DISH. Early-phase DISH was marked by new involvement of previously unaffected motion segments, estimated to occur over 2.1 years. Advanced presentations of DISH were marked by increased prevalence of complete bridging (average two of three available motion segments), estimated to occur over 2.6\u20132.9 years. Localised nodules of ectopic mineralisation external to and within the intervertebral disc were regularly observed in early-phase DISH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first characterisation of spatiotemporal features across all phases of DISH, indicating that progression of DISH is characterised by distinct features at different phases along the disease continuum. Localised nodules of mineralisation in the spinal ligaments and within the intervertebral discs coincident with early phases of the disease may be a key factor in the pathogenesis of DISH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004074","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T10:25:24Z","timestamp":1714213524000},"page":"e004074","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Spatiotemporal changes in imaging features associated with diffuse idiopathic skeletal hyperostosis (DISH)"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-8447","authenticated-orcid":false,"given":"Dale E.","family":"Fournier","sequence":"first","affiliation":[{"name":"Health and Rehabilitation Sciences (Physical Therapy), Faculty of Health Sciences, The University of Western Ontario, London, ON, Canada"},{"name":"Bone and Joint Institute, The University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele C.","family":"Battie","sequence":"additional","affiliation":[{"name":"Bone and Joint Institute, The University of Western Ontario, London, ON, Canada"},{"name":"School of Physical Therapy, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryle A.","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"Bone and Joint Institute, The University of Western Ontario, London, ON, Canada"},{"name":"Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"2025090312525870000_10.2.e004074.1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.9.4.321"},{"key":"2025090312525870000_10.2.e004074.2","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/rheumatology\/kead362","article-title":"Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and early-phase DISH across the LifeSpan of an American population","volume":"63","author":"Fournier","year":"2024","journal-title":"Rheumatology (Oxford)"},{"key":"2025090312525870000_10.2.e004074.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.165"},{"key":"2025090312525870000_10.2.e004074.4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0307-742X(21)00544-0","article-title":"Diffuse idiopathic skeletal hyperostosis","volume":"11","author":"Utsinger","year":"1985","journal-title":"Clin Rheum Dis"},{"key":"2025090312525870000_10.2.e004074.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0693-z"},{"key":"2025090312525870000_10.2.e004074.6","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/jgs.14810","article-title":"Diffuse idiopathic skeletal hyperostosis (DISH) and impaired physical function: the rancho Bernardo study","volume":"65","author":"Katzman","year":"2017","journal-title":"J Am Geriatr Soc"},{"key":"2025090312525870000_10.2.e004074.7","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.spinee.2022.03.002","article-title":"Diffuse idiopathic skeletal hyperostosis of the cervical spine causing dysphagia and airway obstruction: an updated systematic review","volume":"22","author":"Harlianto","year":"2022","journal-title":"Spine J"},{"key":"2025090312525870000_10.2.e004074.8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00007632-198707000-00003","article-title":"Osteophytes of the spine compressing the sympathetic trunk and Splanchnic nerves in the Thorax","volume":"12","author":"Nathan","year":"1987","journal-title":"Spine (Phila Pa 1976)"},{"key":"2025090312525870000_10.2.e004074.9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/27.5.407"},{"key":"2025090312525870000_10.2.e004074.10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3340\/jkns.2007.42.6.487","article-title":"Complete cord injury after minimal trauma in a patient with Forestier\u2019s disease accompanying ossification of the posterior longitudinal ligament","volume":"42","author":"Oh","year":"2007","journal-title":"J Korean Neurosurg Soc"},{"key":"2025090312525870000_10.2.e004074.11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s00774-017-0901-0","article-title":"Diffuse idiopathic Skeletal Hyperostosis is associated with lumbar spinal stenosis requiring surgery","volume":"37","author":"Yamada","year":"2019","journal-title":"J Bone Miner Metab"},{"key":"2025090312525870000_10.2.e004074.12","doi-asserted-by":"crossref","unstructured":"Tsuji O , Suda K , Takahata M , et al . 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