{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:45:15Z","timestamp":1786488315424,"version":"build-2736575974"},"reference-count":62,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["101007757"],"award-info":[{"award-number":["101007757"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute Health Research Doctoral Research Fellowship","award":["NIHR302335"],"award-info":[{"award-number":["NIHR302335"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,11,22]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:p>It is known that 25%\u201330% of individuals with cutaneous psoriasis (PsC) will develop psoriatic arthritis (PsA). To date, the reasons for the development of PsA in individuals with PsC have not been identified. Furthermore, there are considerable delays in the diagnosis and treatment of PsA, which lead to joint and bone deformation and chronic pain. It is therefore important to develop more precise diagnostic and screening tools. In this narrative review of the literature, clinical risk factors and novel molecular biomarkers (genetic markers, blood and inflammatory markers, lipid, metabolite and protein biomarkers) have been evaluated. The review included 38 publications that were reported between May 2020 and May 2024. Similar to previous reviews, nail involvement was one of the strongest clinical risk factors for the development of PsA, while molecular biomarkers did not provide a clear and robust differentiation between PsC and PsA groups. The seemingly poor performance of molecular markers may be largely attributed to small study populations and heterogeneity in study designs. Data and sample sharing in large consortia such as HIPPOCRATES (Health initiatives in Psoriasis and PsOriatic arthritis ConsoRTium European States) could help to overcome the limitations of small studies and enable the development of more robust diagnostic and screening tools for PsA.<\/jats:p>","DOI":"10.1136\/rmdopen-2024-004176","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T23:40:27Z","timestamp":1734046827000},"page":"e004176","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical, genetic and omics-based biomarkers that might support the identification of the development of psoriatic arthritis in individuals with psoriasis: a narrative review of the literature"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2952-6201","authenticated-orcid":false,"given":"Teresa","family":"Grohmann","sequence":"first","affiliation":[{"name":"School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4605-6598","authenticated-orcid":false,"given":"Arani","family":"Vivekanantham","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-663X","authenticated-orcid":false,"given":"Laura C","family":"Coates","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-1015","authenticated-orcid":false,"given":"Stephen","family":"Pennington","sequence":"additional","affiliation":[{"name":"School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6607-6070","authenticated-orcid":false,"given":"Oliver","family":"FitzGerald","sequence":"additional","affiliation":[{"name":"School of Medicine, Conway Institute, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"2025090312544088000_10.4.e004176.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201706"},{"key":"2025090312544088000_10.4.e004176.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.027"},{"key":"2025090312544088000_10.4.e004176.3","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/rheumatology\/keg445","article-title":"A classification study of clinical subsets in an inception cohort of early psoriatic peripheral arthritis--\u2019DIP or not DIP revisited\u2019","volume":"42","author":"Kane","year":"2023","journal-title":"Rheumatol Sunnyvale"},{"key":"2025090312544088000_10.4.e004176.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204858"},{"key":"2025090312544088000_10.4.e004176.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0175-0"},{"key":"2025090312544088000_10.4.e004176.6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/art.39494","article-title":"The Incidence and Risk Factors for Psoriatic Arthritis in Patients With Psoriasis: A Prospective Cohort Study","volume":"68","author":"Eder","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.7","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02545-4","article-title":"Clinical, laboratory, and genetic markers for the development or presence of psoriatic arthritis in psoriasis patients: a systematic review","volume":"23","author":"Mulder","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"2025090312544088000_10.4.e004176.8","article-title":"Prevalence and Clinical Predictors of Psoriatic Arthritis in Saudi Patients With Psoriasis: A Single-Center Retrospective Cohort Study","volume":"15","author":"Alrubaiaan","year":"2023","journal-title":"Cureus"},{"key":"2025090312544088000_10.4.e004176.9","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.201123"},{"key":"2025090312544088000_10.4.e004176.10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.5114\/reum.2021.112238","article-title":"Psoriatic arthritis among Egyptian patients with psoriasis attending the dermatology clinic: prevalence, comorbidities, and clinical predictors","volume":"59","author":"El-Garf","year":"2021","journal-title":"Reumatologia"},{"key":"2025090312544088000_10.4.e004176.11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.740968","article-title":"Predicting the Risk of Psoriatic Arthritis in Plaque Psoriasis Patients: Development and Assessment of a New Predictive Nomogram","volume":"12","author":"Liu","year":"2021","journal-title":"Front Immunol"},{"key":"2025090312544088000_10.4.e004176.12","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2147\/CCID.S413853","article-title":"The Combination of IL-6, PLR and Nail Psoriasis: Screen for the Early Diagnosis of Psoriatic Arthritis","volume":"16","author":"Liu","year":"2023","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"2025090312544088000_10.4.e004176.13","doi-asserted-by":"crossref","DOI":"10.1177\/03000605231221014","article-title":"Predictive factors of psoriatic arthritis in a diverse population with psoriasis","volume":"52","author":"Loo","year":"2024","journal-title":"J Int Med Res"},{"key":"2025090312544088000_10.4.e004176.14","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s13555-023-01025-8","article-title":"Prevalence of Musculoskeletal Symptoms in Patients with Psoriasis and Predictors Associated with the Development of Psoriatic Arthritis: Retrospective Analysis of a US Claims Database","volume":"13","author":"Merola","year":"2023","journal-title":"Dermatol Ther (Heidelb)"},{"key":"2025090312544088000_10.4.e004176.15","doi-asserted-by":"crossref","DOI":"10.2196\/39972","article-title":"Machine Learning Approaches for Predicting Psoriatic Arthritis Risk Using Electronic Medical Records: Population-Based Study","volume":"25","author":"Lee","year":"2023","journal-title":"J Med Internet Res"},{"key":"2025090312544088000_10.4.e004176.16","doi-asserted-by":"crossref","DOI":"10.1038\/s41746-023-00757-3","article-title":"Multi-modality data-driven analysis of diagnosis and treatment of psoriatic arthritis","volume":"6","author":"Xu","year":"2023","journal-title":"NPJ Digit Med"},{"key":"2025090312544088000_10.4.e004176.17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/rheumatology\/keab310","article-title":"Using Bayesian networks to identify musculoskeletal symptoms influencing the risk of developing psoriatic arthritis in people with psoriasis","volume":"61","author":"Green","year":"2022","journal-title":"Rheumatology (Sunnyvale)"},{"key":"2025090312544088000_10.4.e004176.18","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s10067-020-05132-1","article-title":"Early diagnosis of psoriatic arthritis among psoriasis patients: clinical experience sharing","volume":"39","author":"Su","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2025090312544088000_10.4.e004176.19","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.723944","article-title":"Early Origins of Psoriatic Arthritis: Clinical, Genetic and Molecular Biomarkers of Progression From Psoriasis to Psoriatic Arthritis","volume":"8","author":"Pennington","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2025090312544088000_10.4.e004176.20","doi-asserted-by":"publisher","DOI":"10.1159\/000343607"},{"key":"2025090312544088000_10.4.e004176.21","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10102387","article-title":"Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis","volume":"10","author":"Gurke","year":"2022","journal-title":"Biomedicines"},{"key":"2025090312544088000_10.4.e004176.22","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/art.42654","article-title":"Prediction of Psoriatic Arthritis in Patients With Psoriasis Using DNA Methylation Profiles","volume":"75","author":"Cruz\u2010Correa","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jdermsci.2022.11.001","article-title":"DNA methylation markers in peripheral blood for psoriatic arthritis","volume":"108","author":"Deng","year":"2022","journal-title":"J Dermatol Sci"},{"key":"2025090312544088000_10.4.e004176.24","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/art.42154","article-title":"Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling","volume":"74","author":"Soomro","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.25","doi-asserted-by":"crossref","first-page":"13554","DOI":"10.1111\/jcmm.15742","article-title":"Overview of the molecular determinants contributing to the expression of Psoriasis and Psoriatic Arthritis phenotypes","volume":"24","author":"Caputo","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2025090312544088000_10.4.e004176.26","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/art.41652","article-title":"Tissue-Resident Memory CD8+ T Cells From Skin Differentiate Psoriatic Arthritis From Psoriasis","volume":"73","author":"Leijten","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.835760","article-title":"Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine Learning","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"2025090312544088000_10.4.e004176.28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010990","article-title":"Blood-Based Immune Profiling Combined with Machine Learning Discriminates Psoriatic Arthritis from Psoriasis Patients","volume":"22","author":"Mulder","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025090312544088000_10.4.e004176.29","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/exd.14424","article-title":"Clinical predictors of psoriatic arthritis and osteoclast differentiation","volume":"30","author":"Lembo","year":"2021","journal-title":"Exp Dermatol"},{"key":"2025090312544088000_10.4.e004176.30","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13080963","article-title":"A Solid-Phase Microextraction-Liquid Chromatography-Mass Spectrometry Method for Analyzing Serum Lipids in Psoriatic Disease","volume":"13","author":"Koussiouris","year":"2023","journal-title":"Metabolites"},{"key":"2025090312544088000_10.4.e004176.31","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02575-y","article-title":"Differences in oxylipin profile in psoriasis versus psoriatic arthritis","volume":"23","author":"Coras","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"2025090312544088000_10.4.e004176.32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jdermsci.2021.03.006","article-title":"Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes","volume":"102","author":"Kishikawa","year":"2021","journal-title":"J Dermatol Sci"},{"key":"2025090312544088000_10.4.e004176.33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/art.42288","article-title":"Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites","volume":"75","author":"Paine","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.34","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1007\/s10067-020-04959-y","article-title":"Plasma gelsolin levels in patients with psoriatic arthritis: a possible novel marker","volume":"39","author":"Esawy","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2025090312544088000_10.4.e004176.35","first-page":"149","article-title":"Serum Calprotectin as a Promising Inflammatory Biomarker in Psoriatic Arthritis: a 1-Year Longitudinal Study","volume":"10","author":"Li","year":"2023","journal-title":"Rheumatol Ther"},{"key":"2025090312544088000_10.4.e004176.36","first-page":"574","article-title":"Differentiating patients with psoriasis from psoriatic arthritis using collagen biomarkers","volume":"41","author":"Holm Nielsen","year":"2023","journal-title":"Clin Exp Rheumatol"},{"key":"2025090312544088000_10.4.e004176.37","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/1756-185X.13997","article-title":"Interleukin-17A biomarker as a predictor for detection of early axial spondyloarthritis changes in patients with psoriasis","volume":"23","author":"Saif","year":"2020","journal-title":"Int J Rheum Dis"},{"key":"2025090312544088000_10.4.e004176.38","first-page":"219","article-title":"Role of musculoskeletal ultrasound, magnetic resonance imaging, and serum chemokine C-X-C motif ligand 10 in early detection of arthritis in patients with psoriasis","volume":"44","author":"Soliman","year":"2022","journal-title":"The Egyp Rheum"},{"key":"2025090312544088000_10.4.e004176.39","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2217\/bmm-2023-0490","article-title":"Could serum HMGB1 levels be a predictor associated with psoriatic arthritis?","volume":"17","author":"Yildirim","year":"2023","journal-title":"Biomark Med"},{"key":"2025090312544088000_10.4.e004176.40","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18940"},{"key":"2025090312544088000_10.4.e004176.41","doi-asserted-by":"crossref","DOI":"10.1186\/1559-0275-10-13","article-title":"Translation of proteomic biomarkers into FDA approved cancer diagnostics: issues and challenges","volume":"10","author":"F\u00fcz\u00e9ry","year":"2013","journal-title":"Clin Proteomics"},{"key":"2025090312544088000_10.4.e004176.42","doi-asserted-by":"crossref","DOI":"10.1186\/1878-5085-4-7","article-title":"Pitfalls and limitations in translation from biomarker discovery to clinical utility in predictive and personalised medicine","volume":"4","author":"Drucker","year":"2013","journal-title":"EPMA J"},{"key":"2025090312544088000_10.4.e004176.43","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-023-03075-3","article-title":"The Biomarker Toolkit - an evidence-based guideline to predict cancer biomarker success and guide development","volume":"21","author":"Savva","year":"2023","journal-title":"BMC Med"},{"key":"2025090312544088000_10.4.e004176.44","unstructured":"Charlton R , Coates L , Galloway J , et al . Diagnostic delay and less intensive therapy for people with psoriatic arthritis compared with rheumatoid arthritis: a nested matched cohort study from within the uk national early inflammatory arthritis audit. ACR Meeting Abstracts. American College of Rheumatology; 2022:74 (Suppl 9). Available: https:\/\/acrabstracts.org\/abstract\/diagnosticdelay-and-less-intensive-therapy-for-people-with-psoriatic-arthritis-compared-with-rheumatoidarthritis-a-nested-matched-cohort-study-from-within-the-uk-national-early-inflammatory-arthrit\/"},{"key":"2025090312544088000_10.4.e004176.45","doi-asserted-by":"crossref","unstructured":"McHugh N , Tillett W , Helliwell P , et al . Enhanced surveillance for the detection of psoriatic arthritis in a UK primary care psoriasis population: results from the TUDOR trial. Rheumatol (Oxford) 2024.:keae374. doi:10.1093\/rheumatology\/keae374","DOI":"10.1093\/rheumatology\/keae374"},{"key":"2025090312544088000_10.4.e004176.46","first-page":"699","article-title":"POS0964\u2005DYNAMIC prediction of psoriatic arthritis in a cohort of psoriasis patients using uk primary care electronic health records","volume":"83","author":"Rudge","year":"2024","journal-title":"EULAR"},{"key":"2025090312544088000_10.4.e004176.47","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1016\/S2665-9913(23)00034-6","article-title":"Association between biological immunotherapy for psoriasis and time to incident inflammatory arthritis: a retrospective cohort study","volume":"5","author":"Singla","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"2025090312544088000_10.4.e004176.48","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-219961"},{"key":"2025090312544088000_10.4.e004176.49","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/art.41946","article-title":"Incidence of Psoriatic Arthritis Among Patients Receiving Biologic Treatments for Psoriasis: A Nested Case\u2013Control Study","volume":"74","author":"Rosenthal","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.50","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-063650","article-title":"Efficacy of guselkumab, a selective IL-23 inhibitor, in Preventing Arthritis in a Multicentre Psoriasis At-Risk cohort (PAMPA): protocol of a randomised, double-blind, placebo controlled multicentre trial","volume":"12","author":"Haberman","year":"2022","journal-title":"BMJ Open"},{"key":"2025090312544088000_10.4.e004176.51","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2024-eular.1493"},{"key":"2025090312544088000_10.4.e004176.52","doi-asserted-by":"crossref","unstructured":"Eder L , Lee K-A , Chandran V , et al . Derivation of a Multivariable Psoriatic Arthritis Risk Estimation Tool (PRESTO): A Step Towards Prevention. Arthritis Rheumatol 2023. doi:10.1002\/art.42661","DOI":"10.1002\/art.42661"},{"key":"2025090312544088000_10.4.e004176.53","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41584-022-00748-w","article-title":"HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritis","volume":"18","author":"FitzGerald","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"2025090312544088000_10.4.e004176.54","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002109","article-title":"Multimodal imaging of the distal interphalangeal-joint synovio-entheseal complex in psoriatic arthritis (MIDAS): a cross-sectional study on the diagnostic accuracy of different imaging modalities comparing psoriatic arthritis to psoriasis and osteoarthritis","volume":"8","author":"Guldberg-M\u00f8ller","year":"2022","journal-title":"RMD Open"},{"key":"2025090312544088000_10.4.e004176.55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/art.41239","article-title":"Association of Structural Entheseal Lesions With an Increased Risk of Progression From Psoriasis to Psoriatic Arthritis","volume":"74","author":"Simon","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"2025090312544088000_10.4.e004176.56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21082740","article-title":"RNAseq-Based Prioritization Revealed COL6A5, COL8A1, COL10A1 and MIR146A as Common and Differential Susceptibility Biomarkers for Psoriasis and Psoriatic Arthritis: Confirmation from Genotyping Analysis of 1417 Italian Subjects","volume":"21","author":"Caputo","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025090312544088000_10.4.e004176.57","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914803","article-title":"The IFIH1\/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis","volume":"24","author":"Coto-Segura","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2025090312544088000_10.4.e004176.58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23074005","article-title":"Profiling Blood Serum Extracellular Vesicles in Plaque Psoriasis and Psoriatic Arthritis Patients Reveals Potential Disease Biomarkers","volume":"23","author":"L\u00e4ttekivi","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025090312544088000_10.4.e004176.59","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/jdv.16203","article-title":"Circulating micro rna s in extracellular vesicles as potential biomarkers for psoriatic arthritis in patients with psoriasis","volume":"34","author":"Pasquali","year":"2020","journal-title":"Acad Dermatol Venereol"},{"key":"2025090312544088000_10.4.e004176.60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.911347","article-title":"NETosis in Psoriatic Arthritis: Serum MPO-DNA Complex Level Correlates With Its Disease Activity","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"2025090312544088000_10.4.e004176.61","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/rheumatology\/keaa405","article-title":"Broad proteomic screen reveals shared serum proteomic signature in patients with psoriatic arthritis and psoriasis without arthritis","volume":"60","author":"Leijten","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2025090312544088000_10.4.e004176.62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1229516","article-title":"Cytokine profile characterization of na\u00efve patients with psoriasis and psoriatic arthritis: implications for a pathogenic disease continuum","volume":"14","author":"Ruscitti","year":"2023","journal-title":"Front Immunol"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2024-004176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T19:54:53Z","timestamp":1756929293000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2024-004176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,12]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/rmdopen-2024-004176"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2024-004176","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}