{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T23:21:25Z","timestamp":1793575285483,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,6,22]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>(1) To assess the progression of ultrasonography-detected synovitis in a cohort of patients with rheumatoid arthritis (RA) in remission during 1 year of follow-up (2) to evaluate the ability of consecutive examinations of ultrasonography to predict relapse (R) or radiographic progression (RP) at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with RA (2010 American College of Rheumatology-European Alliance of Associations for Rheumatology criteria) in clinical remission (Disease Activity Score in 28 joints (DAS28)&lt;2.6 without clinically active synovitis) were included. An independent investigator performed ultrasonography every 3 months for 1 year. Ultrasonography-detected synovitis was defined as power Doppler-positive ultrasonography synovitis (PDUS) grade \u22651 in at least one joint. PDUS at \u22652 consecutive visits during the follow-up defined persistent PDUS. An increase of \u22651 point in the modified total Sharp score defined RP. An increase in DAS28-C-reactive protein (CRP)&gt;0.6\u2009or DAS28-CRP&gt;3.2\u2009and any modification of disease-modifying anti-rheumatic drugs or glucocorticoids defined relapse. Univariate and multivariate Cox regression analyses were used to evaluate factors associated with R\/RP at 1 year.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>PDUS was detected in 75 (65.2%), 66, 60, 46 and 29 of the 115 patients with RA at baseline and at months 3, 6, 9 and 12, respectively. 58 (50.4%) patients exhibited persistent PDUS. After 1 year, 22\/85 (25.9%) experienced relapse and 12 (14.1%) showed RP. On multivariate analysis, factors predicting R\/RP at 1 year were persistent PDUS (HR=2.98, p=0.014) and an increase in DAS28-CRP level at the visit before relapse (HR=4.36, p=0.004).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Persistent PDUS during follow-up, rather than at baseline, predicted worse outcome at 1 year and requires careful monitoring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004269","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T21:50:12Z","timestamp":1726609812000},"page":"e004269","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Persistence of power Doppler ultrasonography-detected synovitis over 1 year of follow-up predicts poor prognosis in rheumatoid arthritis in clinical remission: the SONORE prospective longitudinal study"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct02618954","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-5035","authenticated-orcid":false,"given":"Gael","family":"Mouterde","sequence":"first","affiliation":[{"name":"Rhumatologie, Centre Hospitalier R\u00e9gional Universitaire de Montpellier, Montpellier, France"},{"name":"University of Montpellier, Montpellier, Occitanie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Lukas","sequence":"additional","affiliation":[{"name":"Rhumatologie, Centre Hospitalier R\u00e9gional Universitaire de Montpellier, Montpellier, France"},{"name":"University of Montpellier, Montpellier, Occitanie, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Filippi","sequence":"additional","affiliation":[{"name":"Rhumatologie, Centre Hospitalier R\u00e9gional Universitaire de 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-6385","authenticated-orcid":false,"given":"Jacques","family":"Morel","sequence":"additional","affiliation":[{"name":"Rhumatologie, Centre Hospitalier R\u00e9gional Universitaire de Montpellier, Montpellier, France"},{"name":"University of Montpellier, Montpellier, Occitanie, 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