{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T17:23:07Z","timestamp":1788196987068,"version":"build-2803163510"},"reference-count":28,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ERC","award":["ERC Synergy grant 4D Nanoscope"],"award-info":[{"award-number":["ERC Synergy grant 4D Nanoscope"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1181"],"award-info":[{"award-number":["CRC1181"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Checkpoints for Resolution of Inflammation \u2013 261"],"award-info":[{"award-number":["Checkpoints for Resolution of Inflammation \u2013 261"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG-FOR2886 PANDORA"],"award-info":[{"award-number":["DFG-FOR2886 PANDORA"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Leibniz Award to GS"],"award-info":[{"award-number":["Leibniz Award to GS"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["NOTICE clinician scientist program to AA, FF, GC"],"award-info":[{"award-number":["NOTICE clinician scientist program to AA, FF, GC"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["Project MASCARA"],"award-info":[{"award-number":["Project MASCARA"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"GRAPPA Pilot Research Grant to DS"},{"name":"Friedrich-Alexander University Erlangen","award":["Emerging Fields Initiative MIRACLE"],"award-info":[{"award-number":["Emerging Fields Initiative MIRACLE"]}]},{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["101007757 (HIPPOCRATES)"],"award-info":[{"award-number":["101007757 (HIPPOCRATES)"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,5,15]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To assess the presence and anatomical distribution of activated fibroblasts in the joints and entheses of patients with psoriasis with arthralgia and to test how fibroblast activation visualised by <jats:sup>68<\/jats:sup>gallium-labelled fibroblast activation protein inhibitor-04 (<jats:sup>68<\/jats:sup>Ga-FAPI-04)-positron emission tomography (PET)\/CT correlates with clinical tenderness, musculoskeletal ultrasound findings and progression to psoriatic arthritis (PsA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective cohort study in patients with psoriasis and arthralgia who underwent clinical and ultrasound evaluation and whole-body PET\/CT imaging with <jats:sup>68<\/jats:sup>Ga-FAPI-04. <jats:sup>68<\/jats:sup>Ga-FAPI-04 uptake at synovial and entheseal sites was assessed by maximal standardised uptake values (SUVmax) and PET\/CT Joint Index (JI); logistic regression models were used to investigate its correlation with clinical and ultrasound findings. Survival analyses were performed on patients with at least 6 months of follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>36 patients with psoriasis were enrolled. <jats:sup>68<\/jats:sup>Ga-FAPI-04 uptake was found in 318 (7.9%) joints and 369 (7.3%) entheses in 29 (80.6%) participants, with a mean SUVmax (SD) of 3.2 (1.8) for joints and 2.9 (1.6) for entheses. Large joints and the lower limbs were predominantly affected. A significant positive relationship was found between <jats:sup>68<\/jats:sup>Ga-FAPI-04-PET\/CT signal intensity and the 68 tender joint count (SUVmax: p&lt;0.001; PET\/CT-JI: p&lt;0.001) and tender entheses count (SUVmax: p&lt;0.001; PET\/CT-JI: p=0.002). No correlations were found with ultrasound findings (SUVmax: p=0.969; PET\/CT-JI: p=0.720). Patients with relevant synovio-entheseal <jats:sup>68<\/jats:sup>Ga-FAPI-04 uptake showed a statistically significant higher risk of developing PsA (p=0.02), independent of ultrasound findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with psoriasis presenting with arthralgia show localised signs of resident tissue activation in joints and entheses, which are associated with higher risk of developing PsA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004294","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T14:12:25Z","timestamp":1718115145000},"page":"e004294","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis"],"prefix":"10.1136","volume":"10","author":[{"given":"Giulia","family":"Corte","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Atzinger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-3198","authenticated-orcid":false,"given":"Selahattin Alp","family":"Temiz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Noversa de Sousa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Servi\u00e7o de Medicina Interna, Hospital Pedro Hispano, Hospital Pedro Hispano, Matosinhos, Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melek Yalcin","family":"Mutlu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-9824","authenticated-orcid":false,"given":"Verena","family":"Schoenau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Kleyer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Department of Rheumatology and Clinical Immunology, Charite University Hospital Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Kuwert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Ramming","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Deutsches Zentrum fuer Immuntherapie (DZI), Erlangen University Hospital, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8310-7820","authenticated-orcid":false,"given":"David","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Rheumatology and Immunology, Erlangen University Hospital, Erlangen, Germany"},{"name":"Department of Rheumatology and Clinical Immunology, Charite University 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