{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T12:38:25Z","timestamp":1770640705881,"version":"3.49.0"},"reference-count":43,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,7,26]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>MicroRNAs (miRNAs) can regulate gene expression, controlling numerous cellular processes. Dysregulation of miRNA function is linked to various diseases, making them attractive diagnostic and therapeutic targets. Examples include hsa-miR-92a-3p, hsa-miR-126-3p, hsa-miR-143-3p, hsa-miR-145-5p and hsa-miR-204-5p, which are associated with endothelial function. Their prevalence in Sj\u00f6gren\u2019s disease (SjD) is unknown. We assessed the prevalence of these miRNAs in serum of patients with SjD, correlating levels with cardiovascular risk factors and carotid intima-media thickness (cIMT) to evaluate their utility in risk stratification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>199 patients with SjD and 100 age and sex-matched healthy controls (HC) were included in the study. Five different miRNAs (hsa-miR-92a-3p; hsa-miR-126-3p; hsa-miR143-3p; hsa-miR-145-5p; hsa-miR-204-5p) were analysed by quantitative real-time PCR. The miRNA results were compared with known clinical and disease-related parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four miRNAs showed significantly different expressions compared with HC. MiR-92a-3p was upregulated (p=0.025) and miR-126-3p (p=0.044), miR-143-3p (p=0.006) and miR-204-5p (p=0.009) downregulated in SjD compared with HC. The comparison between HC and SjD with\/without organ involvement revealed descriptively increased miR-92a-3p levels in patients with SjD with organ involvement (p=0.087). Furthermore, miR-92a-3p levels correlated positively with cIMT as an expression of subclinical atherosclerosis (r=0.148, p=0.04).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In conclusion, patients with SjD demonstrated differences in their expression of miRNAs linked to regulation of endothelial function. Reduction of specific miRNAs was associated with increased cardiovascular risk, suggesting a potentially protective role for these miRNAs. Furthermore, miR-92a-3p could be helpful for molecular detection of early-stage atherosclerosis and increased cardiovascular risk in SjD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004434","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T01:00:30Z","timestamp":1724374830000},"page":"e004434","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["miRNAs as potential biomarkers for subclinical atherosclerosis in Sj\u00f6gren\u2019s disease"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1556-790X","authenticated-orcid":false,"given":"Nadine","family":"Zehrfeld","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Lower Saxony, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Abelmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany"},{"name":"Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Niedersachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Benz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Lower Saxony, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-6826","authenticated-orcid":false,"given":"Tabea","family":"Seeliger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Engelke","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Lower Saxony, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Skripuletz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Baer","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Niedersachsen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Niedersachsen, 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"2025090312070315000_10.3.e004434.1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07511"},{"key":"2025090312070315000_10.3.e004434.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0218-x"},{"key":"2025090312070315000_10.3.e004434.3","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2015"},{"key":"2025090312070315000_10.3.e004434.4","doi-asserted-by":"publisher","DOI":"10.1113\/JP278131"},{"key":"2025090312070315000_10.3.e004434.5","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2096"},{"key":"2025090312070315000_10.3.e004434.6","doi-asserted-by":"publisher","DOI":"10.1093\/EURHEARTJ\/EHY234"},{"key":"2025090312070315000_10.3.e004434.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.05.185"},{"key":"2025090312070315000_10.3.e004434.8","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04558-w","article-title":"Circulating 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