{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:34:08Z","timestamp":1771479248341,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Innovative Medicines Initiative 2 Joint Undertaking","award":["806975"],"award-info":[{"award-number":["806975"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,7,27]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop and validate a web-based ecological momentary assessment (EMA) tool to enhance symptoms monitoring among patients with Sj\u00f6gren\u2019s disease (SjD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive adults with SjD were enrolled in this pilot observational study. Participants used the WebApp over a 3-month period, for the daily collection of individual EULAR Sj\u00f6gren\u2019s Syndrome Patient Reported Index (ESSPRI) scales and separate assessment of eyes and mouth dryness, using 0\u201310 numerical scales. Primary outcome was the measure of the interdaily variability of symptoms. Data collected through the WebApp were compared with those obtained with paper-based questionnaires administered during a final visit, using distinct approaches (predicted error, maximum negative error and maximum positive error). User experience was assessed using the System Usability Scale (SUS) score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 45 participants, 41 (91.1%) were women. Median age was 57 years (IQR: 49\u201366). Daily variability of symptoms ranged between 0.5 and 0.8 points across the scales. Over the 3-month period, the predicted error ranged between \u22121.2 and \u22120.3 points of the numerical scales. The greatest differences were found for fatigue (\u22121.2 points (IQR: \u22122.3 to \u22120.2)) and ESSPRI score (\u22121.2 points (IQR: \u22121.7 to \u22120.3)). Over the last 2 weeks, the predicted error ranged between \u2013 1.2 and 0.0 points. Maximum negative error ranged between \u22122.0 and \u22121.0 points, and maximum positive error between \u22120.3 and 0.0 points. Median SUS score was 90 (IQR: 85\u201395).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results demonstrate the usability and the relevance of our web-based EMA tool for capturing data that closely reflects daily experiences of patients with SjD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004526","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T07:50:15Z","timestamp":1727855415000},"page":"e004526","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a web-based ecological momentary assessment tool to measure day-to-day variability of the symptoms in patients with Sj\u00f6gren\u2019s disease"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct05113004","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Laurie","family":"Georgel","sequence":"first","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas-Alexis","family":"Benyoussef","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofian","family":"Berrouiguet","sequence":"additional","affiliation":[{"name":"Psychiatry Department, CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-4805","authenticated-orcid":false,"given":"Dewi","family":"Guellec","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"},{"name":"LBAI, Univ Brest, Inserm, Brest, France, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-5445","authenticated-orcid":false,"given":"Guillermo","family":"Carvajal Alegria","sequence":"additional","affiliation":[{"name":"Rheumatology, CHU Tours, Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Marhadour","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5479-5887","authenticated-orcid":false,"given":"Sandrine","family":"Jousse-Joulin","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"},{"name":"LBAI, Univ Brest, Inserm, Brest, France, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9atrice","family":"Cochener-Lamard","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, CHU de Brest, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Labetoulle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, H\u00f4pital Bic\u00eatre, Le Kremlin-Bicetre, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9469-946X","authenticated-orcid":false,"given":"Jacques-Eric","family":"Gottenberg","sequence":"additional","affiliation":[{"name":"Rheumatology, Hopitaux universitaires de Strasbourg, Strasbourg, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Bourcier","sequence":"additional","affiliation":[{"name":"Ophtalmology, CHU de Strasbourg, Strasbourg, Grand Est, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-0733","authenticated-orcid":false,"given":"Ga\u00e9tane","family":"Nocturne","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux universitaires Paris-Sud \u2013 H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud, Center for Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) UMR 1184, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7067","authenticated-orcid":false,"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"},{"name":"LBAI, Univ Brest, Inserm, Brest, France, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-5417","authenticated-orcid":false,"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux universitaires Paris-Sud \u2013 H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud, Center for Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) UMR 1184, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00eblys","family":"Consigny","sequence":"additional","affiliation":[{"name":"Brest University Hospital, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Gravey","sequence":"additional","affiliation":[{"name":"Sys.vision, Lannion, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Devauchelle-Pensec","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, France"},{"name":"LBAI, Univ Brest, Inserm, Brest, France, Brest, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5523-1856","authenticated-orcid":false,"given":"Raphaele","family":"Seror","sequence":"additional","affiliation":[{"name":"Rheumatology, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pitaux universitaires Paris-Sud \u2013 H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"},{"name":"Universit\u00e9 Paris-Sud, Center for Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Sant\u00e9 et la Recherche M\u00e9dicale (INSERM) UMR 1184, Universit\u00e9 Paris-Saclay, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-702X","authenticated-orcid":false,"given":"Divi","family":"Cornec","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centre National de R\u00e9f\u00e9rence des Maladies Auto-Immunes Rares (CERAINOM), CHU Brest, Brest, 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