{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:40:37Z","timestamp":1792676437473,"version":"4.5.0"},"reference-count":48,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["SA-003854"],"award-info":[{"award-number":["SA-003854"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["171102014"],"award-info":[{"award-number":["171102014"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["WI229707"],"award-info":[{"award-number":["WI229707"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2024,9,29]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate whether a combination of general health (Visual Analogue Scale (VAS)), Health Assessment Questionnaire-Disability Index (HAQ-DI), pain (VAS\/Numerical Rating Scale (NRS)), quality of life (EQ-5D), fatigue (VAS\/NRS) and presenteeism (0%\u2013100%\u2009productivity loss) could aid as a screening tool to detect active disease in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>RA patients from the tREACH trial and TARA trial (n=683) and PsA patients from the DEPAR cohort (n=525) were included. The association of a deterioration in the aforementioned patient-reported outcome measure (PROM) scores between two consecutive visits and having active disease was assessed. Active disease was defined as a change from disease activity score (DAS) \u22642.4\u2009to DAS &gt;2.4 in RA or Disease Activity Index in Psoriatic Arthritis (DAPSA) \u226414\u2009to DAPSA &gt;14 in PsA. The area under the curve (AUC) of the sum score of deteriorated PROMs was evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>4594 RA and 1154 PsA visits were evaluated and active disease occurred in 358 (8%) RA and 177 (15%) PsA visits. In both RA and PsA, a deterioration in general health (VAS), HAQ-DI, EQ-5D and pain (VAS\/NRS) was significantly associated with active disease. The combination of these PROMs showed acceptable to excellent discriminative ability (RA AUC=0.76, PsA AUC=0.85). If a cut-point of \u22651 deteriorated PROMs is used, 40% of the visits in which RA patients have remission or low disease activity are correctly specified (specificity of 40%), while 10% of visits with active disease are overlooked (sensitivity of 90%). In PsA, these percentages are 41% and 4%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A combination of general health, HAQ-DI, EQ-5D and pain could aid as a screening tool for active disease in patients with RA and PsA. These data could help facilitate remote monitoring of RA and PsA patients in the future.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration numbers<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"isrctn\" xlink:href=\"ISRCTN26791028\">ISRCTN26791028<\/jats:ext-link>, NTR2754.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-004687","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T14:00:28Z","timestamp":1729260028000},"page":"e004687","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Combining patient-reported outcome measures to screen for active disease in rheumatoid arthritis and psoriatic arthritis"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"isrctn26791028","registry":"10.18810\/isrctn"},{"clinical-trial-number":"isrctn26791028","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-2182","authenticated-orcid":false,"given":"Agnes E M","family":"Looijen","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-7777","authenticated-orcid":false,"given":"Selinde V J","family":"Snoeck Henkemans","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8572-1437","authenticated-orcid":false,"given":"Annette H M","family":"van der Helm-van Mil","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"},{"name":"Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paco M J","family":"Welsing","sequence":"additional","affiliation":[{"name":"Department of Rheumatology & Clinical Immunology and Julius Center, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3787-4552","authenticated-orcid":false,"given":"Gonul Hazal","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-7932","authenticated-orcid":false,"given":"Jolanda J","family":"Luime","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-6926","authenticated-orcid":false,"given":"Marc R","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Maasstad Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilja","family":"Tchetverikov","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Albert Schweitzer Hospital, Dordrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindy-Anne","family":"Korswagen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Baudoin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Reumazorg Zuid West Nederland, Roosendaal, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijn","family":"Vis","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-6222","authenticated-orcid":false,"given":"Pascal H P","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Erasmus MC, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"2025090313244200000_10.4.e004687.1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211734"},{"key":"2025090313244200000_10.4.e004687.2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"2025090313244200000_10.4.e004687.3","unstructured":"Smolen JS , Landew\u00e9 RBM , Bergstra SA , et al . 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Responsiveness and sensitivity of PROMs to change in disease activity status in early and established rheumatoid arthritis. 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