{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:08:28Z","timestamp":1793052508972,"version":"4.5.0"},"reference-count":41,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"unspecified","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Finnish Society for Rheumatology scientific funding resource"},{"name":"Helsinki University Library"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2025,3,22]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The age at the onset of juvenile idiopathic arthritis (JIA) can influence the trajectory of the disease. We aimed to clarify how age at the visit 6 months after the onset as a continuous variable affects long-term remission of JIA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study investigated 358 patients from the Nordic JIA cohort study. Age at diagnosis was analysed continuously. Three age groups were studied: under 3 years, 3\u20135 years and over 6 years of age. JIA was categorised as oligoarthritis, seronegative polyarthritis and others (enthesitis-related, psoriatic and undifferentiated arthritis). Clinical data, collected at 6 months after the onset of symptoms, included information about disease activity, uveitis, laboratory test values and medication. The outcomes assessed 17.5 years after diagnosis included remission, health-related quality of life (HRQoL), and functional ability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The majority of patients with oligoarthritis and polyarthritis were diagnosed before age six, compared with 29% in the group of others. In the oligoarthritis group, predictors of remission included age at diagnosis, male gender, the Juvenile Arthritis Disease Activity Score-71 (JADAS71) and the absence of uveitis. In seronegative polyarthritis, predictors of remission were age at diagnosis and JADAS71 score. In the oligoarthritis group, remission rates were highest in both genders when diagnosed &lt;3 years of age. In the seronegative polyarthritis group, this was not true for female patients. Age at diagnosis had no significant effect on HRQoL or functional ability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Age at diagnosis in the oligoarthritis was inversely and in the seronegative polyarthritis positively associated with long-term remission in JIA, primarily in females.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-005369","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T02:45:20Z","timestamp":1749609920000},"page":"e005369","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Age at diagnosis as a prognostic factor in selected categories of juvenile idiopathic 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Norwegian University of Science and Technology, Trondheim, Tr\u00f8ndelag, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillemor","family":"Berntson","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala Universitet, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Fasth","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden"},{"name":"Institute of Clinical Science, Sahlgrenska Academy, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-9908","authenticated-orcid":false,"given":"Mia","family":"Glerup","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus Universitet, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Primary Health Care Unit Kuopio, Kuopio University Hospital, Kuopio, Finland"},{"name":"Folkh\u00e4lsan Research Center, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Berit","family":"Nordal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Research Group, University Hospital of North Norway, Troms\u00f8, Troms, Norway"},{"name":"Department of Clinical Medicine, Research Group for Child and Adolescent Health, UiT The Arctic University of Norway, Troms\u00f8, Troms, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi","family":"Peltoniemi","sequence":"additional","affiliation":[{"name":"University of Helsinki, Helsinki, Uusimaa, Finland"},{"name":"HUS Inflammation Center, Rheumatology, Helsinki University Central Hospital, Helsinki, Uusimaa, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marite","family":"Rygg","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Tr\u00f8ndelag, Norway"},{"name":"Department of Pediatrics, St Olavs Hospital Universitetssykehuset i Trondheim, Trondheim, Tr\u00f8ndelag, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-305X","authenticated-orcid":false,"given":"Veronika","family":"Rypdal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Research Group, University Hospital 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