{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:53:04Z","timestamp":1793141584972,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2025,3,19]]},"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Superb microvascular imaging (SMI) provides a more sensitive assessment of small vessels compared with power and colour Doppler ultrasonography (PDUS and CDUS). We aimed to investigate the potential of SMI for use in research and clinical practice in Beh\u00e7et syndrome (BS) and to gain a better understanding of erythema nodosum (EN) like and superficial thrombophlebitis (STM) lesions using SMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied 51 patients with BS and 31 patients with non-BS with red palpable lesions on physical examination. B-mode US, CDUS, PDUS and SMI were performed and recorded by the same radiologist and recorded images were additionally evaluated independently by another radiologist. Vessel-wall signal intensity of STM lesions by SMI was graded in four groups according to the percentages of the affected vessel-wall area (Grade 0: no signal, Grade 1: &lt; 25%, Grade 2: 25%\u201350%, Grade 3: 50%\u201375% and Grade 4: &gt;75%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The lesions of 26 patients with BS and 17 patients with non-BS were diagnosed as STM with CDUS. SMI of STM lesions revealed vessel-wall signals in 21\/26 patients with BS (81%), in contrast to only 3\/17 (18%) patients with non-BS. While 16 of 21 patients with BS (76%) had at least grade 2 signal, only 1 of 3 non-BS had it. Lesions of 25 BS and 11 non-BS were diagnosed as EN by CDUS and SMI showed no vessel-wall signal in these patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Evaluation of the vessel wall with SMI in BS may be a promising approach for showing inflammation as an inexpensive, non-invasive and reliable imaging method that does not require a contrast agent.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/rmdopen-2024-005382","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T10:10:21Z","timestamp":1743847821000},"page":"e005382","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Venous vessel-wall assessment with superb microvascular imaging in Beh\u00e7et syndrome"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1590-5382","authenticated-orcid":false,"given":"Yasemin","family":"Kayadibi","sequence":"first","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-4715","authenticated-orcid":false,"given":"Yesim","family":"Ozguler","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey"},{"name":"Beh\u00e7et\u2019s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-8368","authenticated-orcid":false,"given":"Melike","family":"Melikoglu","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey"},{"name":"Beh\u00e7et\u2019s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5414-7305","authenticated-orcid":false,"given":"Sinem Nihal","family":"Esatoglu","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey"},{"name":"Beh\u00e7et\u2019s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-0183","authenticated-orcid":false,"given":"Ugur","family":"Kimyon","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8433-1883","authenticated-orcid":false,"given":"Ayse","family":"Kalyoncu Ucar","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4531-6466","authenticated-orcid":false,"given":"Ibrahim","family":"Adaletli","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Radiology, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1952-1135","authenticated-orcid":false,"given":"Gulen","family":"Hatemi","sequence":"additional","affiliation":[{"name":"Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey"},{"name":"Beh\u00e7et\u2019s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"2025090313003921000_11.2.e005382.1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200301000-00006"},{"key":"2025090313003921000_11.2.e005382.2","doi-asserted-by":"crossref","unstructured":"Ozguler Y , Esatoglu S , Seyahi E , et al . Vascular and cardiac involvement. In: Yazici Y , Hatemi G , Seyahi E , et al ., eds. Beh\u00e7et syndrome. Switzerland: Springer Nature, 2020: 83\u2013104.","DOI":"10.1007\/978-3-030-24131-5_7"},{"key":"2025090313003921000_11.2.e005382.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu233"},{"key":"2025090313003921000_11.2.e005382.4","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2011.026","article-title":"Beh\u00e7et\u2019s Syndrome and Thrombosis","volume":"3","author":"Seyahi","year":"2011","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"2025090313003921000_11.2.e005382.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02832.x"},{"key":"2025090313003921000_11.2.e005382.6","doi-asserted-by":"publisher","DOI":"10.1080\/03009740500255761"},{"key":"2025090313003921000_11.2.e005382.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109318"},{"key":"2025090313003921000_11.2.e005382.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00880-7"},{"key":"2025090313003921000_11.2.e005382.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214335"},{"key":"2025090313003921000_11.2.e005382.10","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13243"},{"key":"2025090313003921000_11.2.e005382.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017738"},{"key":"2025090313003921000_11.2.e005382.12","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1349"},{"key":"2025090313003921000_11.2.e005382.13","doi-asserted-by":"publisher","DOI":"10.1136\/pn-2023-003875"},{"key":"2025090313003921000_11.2.e005382.14","article-title":"Pathologic Features of Beh\u00e7et\u2019s Disease in the Tubuler Gut","volume":"2012","author":"Kara","year":"2012","journal-title":"Patholog Res Int"},{"key":"2025090313003921000_11.2.e005382.15","first-page":"S91","article-title":"Histopathology of the ruptured pulmonary artery aneurysm in a patient with Beh\u00e7et\u2019s disease","volume":"27","author":"Hirohata","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313003921000_11.2.e005382.16","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_229_22"},{"key":"2025090313003921000_11.2.e005382.17","doi-asserted-by":"publisher","DOI":"10.1309\/GCTH-0060-55K8-XCTT"},{"key":"2025090313003921000_11.2.e005382.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80318-0"},{"key":"2025090313003921000_11.2.e005382.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1989.tb00049.x"},{"key":"2025090313003921000_11.2.e005382.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.03.032"},{"key":"2025090313003921000_11.2.e005382.21","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15008"},{"key":"2025090313003921000_11.2.e005382.22","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-136"},{"key":"2025090313003921000_11.2.e005382.23","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15907"},{"key":"2025090313003921000_11.2.e005382.24","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1433"},{"key":"2025090313003921000_11.2.e005382.25","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1051862","article-title":"Clinical study of carotid superb microvascular imaging in evaluating the activity of Takayasu\u2019s arteritis","volume":"10","author":"Liu","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2025090313003921000_11.2.e005382.26","first-page":"S99","article-title":"Magnetic resonance imaging of vein wall thickness in patients with Beh\u00e7et\u2019s syndrome","volume":"32","author":"Ambrose","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"2025090313003921000_11.2.e005382.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2023.152246"},{"key":"2025090313003921000_11.2.e005382.28","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-024-06911-w"},{"key":"2025090313003921000_11.2.e005382.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103487"},{"key":"2025090313003921000_11.2.e005382.30","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead476"},{"key":"2025090313003921000_11.2.e005382.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109306"},{"key":"2025090313003921000_11.2.e005382.32","doi-asserted-by":"publisher","DOI":"10.46497\/ArchRheumatol.2021.8423"},{"key":"2025090313003921000_11.2.e005382.33","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa264"},{"key":"2025090313003921000_11.2.e005382.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2018.11.006"},{"key":"2025090313003921000_11.2.e005382.35","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-021-00527-8"},{"key":"2025090313003921000_11.2.e005382.36","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/jey285","article-title":"Visualization of arterial wall vascularization using superb microvascular imaging in active-stage Takayasu arteritis","volume":"20","author":"Sato","year":"2019","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2025090313003921000_11.2.e005382.37","unstructured":"Aladag Kurt S , Ozguler Y . Superb mikrovask\u00fcler g\u00f6r\u00fcnt\u00fcleme i\u0307le tani alan temporal arterit olgu sunumu: aktif d\u00f6nem ve tedavi sonrasi bulgular. Turkish national radiology congress, Turkrad-2021, pg 556 26-30. Antalya, Turkey, 2021."},{"key":"2025090313003921000_11.2.e005382.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.10.064"},{"key":"2025090313003921000_11.2.e005382.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109341"},{"key":"2025090313003921000_11.2.e005382.40","first-page":"40","article-title":"Venous thrombosis and relapses in patients with Beh\u00e7et\u2019s disease. Descriptive analysis from Spanish network of Beh\u00e7et\u2019s disease (REGEB cohort)","volume":"36","author":"Rodr\u00edguez-Carballeira","year":"2018","journal-title":"Clin Exp Rheumatol"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2024-005382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T20:00:51Z","timestamp":1756929651000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2024-005382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,4,5]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1136\/rmdopen-2024-005382"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2024-005382","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}