{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:34:36Z","timestamp":1787319276610,"version":"build-2736575974"},"reference-count":15,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"unspecified","delay-in-days":20,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2025,7,5]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the performance in adults of the European Alliance of Associations for Rheumatology (EULAR)\/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 classification criteria for IgA vasculitis (IgAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The EULAR\/PReS\/Ankara 2008 classification criteria for IgAV were applied to patients enrolled in an international observational cohort which included patients with IgAV and comparators with other forms of small-vessel and medium-vessel vasculitis. After the initial assessment of the performance of the criteria, possible revisions to increase the performance were tested. The revised criteria were then assessed in an independent validation cohort within a multicentre Turkish vasculitis registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dataset consisted of 178 IgAV cases and 1705 comparators. The Ankara 2008 criteria require skin involvement plus one of the following four criteria: abdominal pain, a biopsy showing IgA deposition, arthritis or arthralgia, or renal involvement (any haematuria and\/or proteinuria). The specificity of the criteria improved when a positive test for anti-neutrophil cytoplasmic autoantibody or blood cryoglobulins was considered an exclusion criterion. The revised criteria had a sensitivity of 76.4% (95% CI 69.8% to 82.2%) and a specificity of 94.5% (95.0% CI 93.4% to 95.1%). In the validation set, the sensitivity and specificity of the revised criteria were 97.8% (95% CI 94.0% to 99.0%) and 85.0% (95.0% CI 78.0% to 90.0%), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The revised EULAR\/PReS-endorsed Ankara 2008 IgAV classification criteria perform well in adults with IgAV and are appropriate for use in clinical research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2025-005728","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:35:21Z","timestamp":1753162521000},"page":"e005728","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Performance in adults of the EULAR\/PRINTO\/PRES (Ankara 2008) classification criteria for IgA vasculitis"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5274-3285","authenticated-orcid":false,"given":"Yagmur","family":"Bayindir","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"Grayson","sequence":"additional","affiliation":[{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B","family":"Gribbons","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selcan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Eskisehir Osmangazi University, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Audemard-Verger","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Universitaire de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-1192","authenticated-orcid":false,"given":"Cristina","family":"Ponte","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Unidade Local de Sa\u00fade Santa Maria, Centro Acad\u00e9mico de Medicina de Lisboa, Lisbon, Portugal"},{"name":"Universidade de Lisboa Faculdade de Medicina, Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna C","family":"Robson","sequence":"additional","affiliation":[{"name":"University of the West of England, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Suppiah","sequence":"additional","affiliation":[{"name":"Auckland District Health Board, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemal","family":"Bes","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am Sakura City Hospital, Department of Rheumatology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bugu","family":"Bulat","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Ba\u015fak\u015fehir \u00c7am Sakura City Hospital, Department of Rheumatology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Karadag","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raashid Ahmed","family":"Luqmani","sequence":"additional","affiliation":[{"name":"University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-4769","authenticated-orcid":false,"given":"Richard A","family":"Watts","sequence":"additional","affiliation":[{"name":"University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Merkel","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-7868","authenticated-orcid":false,"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2025121606200914000_11.3.e005728.1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37715"},{"key":"2025121606200914000_11.3.e005728.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex158"},{"key":"2025121606200914000_11.3.e005728.3","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/art.1780330809","article-title":"The American College of Rheumatology 1990 criteria for the classification of henoch\u2010sch\u00f6nlein purpura","volume":"33","author":"Mills","year":"1990","journal-title":"Arthritis Rheum"},{"key":"2025121606200914000_11.3.e005728.4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.116657"},{"key":"2025121606200914000_11.3.e005728.5","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/rheumatology\/kex075","article-title":"Are the 1990 American College of Rheumatology 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