{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:27:57Z","timestamp":1793399277104,"version":"4.5.0"},"reference-count":56,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"unspecified","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2025,11,4]]},"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>Juvenile idiopathic arthritis-associated uveitis (JIAU) is a potentially blinding condition beginning in childhood. Flare-ups may occur throughout life, leading to cumulative ocular damage. This systematic review aimed to summarise the latest evidence on long-term ocular damage in adults with JIAU, focusing on studies published in the past 20 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The review protocol was registered in PROSPERO (ID 1033522). We included human studies on JIAU with at least 5 years of follow-up and\/or young people \u226518 years old, published after 2000. Study quality was assessed using the Newcastle-Ottawa Scale. We extracted the cumulative incidence of complications and performed a meta-analysis to obtain pooled estimates (PE), assess heterogeneity, sensitivity, robustness and reporting bias using R packages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>22 retrospective or cohort studies were eligible, encompassing 2208 long-term JIAU cases. Study quality was rated as good in 10, fair in 7 and poor in 5. Despite high heterogeneity (p&lt;0.01), sensitivity analyses supported robustness. Evidence of reporting bias was found for severe visual impairment and cataract. The pooled incidence of severe visual impairment was 16.6% (95% CI 9.9% to 22.6%) at approximately 18 years. Cataract was the most frequent complication (PE 44.3% (95%\u2009CI 27.5% to 61.7%)), followed by glaucoma, synechiae, band keratopathy and hypotony. In cohorts with &gt;50% biologic exposure, PE were numerically lower.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term prevalence and cumulative incidence of JIAU complications may persist in adulthood, with &gt;10% developing severe visual impairment despite biologic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2025-006071","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T05:05:35Z","timestamp":1764306335000},"page":"e006071","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Long-term outcomes of JIA-associated uveitis: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"11","clinical-trial-number":[{"clinical-trial-number":"nct04200833","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4314-5835","authenticated-orcid":false,"given":"Laura","family":"Scagnellato","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8895-7717","authenticated-orcid":false,"given":"Giacomo","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Lorenzin","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Poncina","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rizzetto","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9683-8873","authenticated-orcid":false,"given":"Roberta","family":"Ramonda","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Medicine\u2014DIMED, Padova University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"2025112721051476000_11.4.e006071.1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130302"},{"key":"2025112721051476000_11.4.e006071.2","doi-asserted-by":"crossref","first-page":"461078","DOI":"10.1155\/2014\/461078","article-title":"The role of gender in juvenile idiopathic arthritis-associated uveitis","volume":"2014","author":"Moradi","year":"2014","journal-title":"J Ophthalmol"},{"key":"2025112721051476000_11.4.e006071.3","doi-asserted-by":"crossref","first-page":"101979","DOI":"10.1016\/j.berh.2024.101979","article-title":"Management of JIA associated uveitis","volume":"38","author":"Maccora","year":"2024","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2025112721051476000_11.4.e006071.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo-2023-324406"},{"key":"2025112721051476000_11.4.e006071.5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/acr.24963","article-title":"New and Updated Recommendations for the Treatment of Juvenile Idiopathic Arthritis\u2013Associated Uveitis and Idiopathic Chronic Anterior Uveitis","volume":"75","author":"Foeldvari","year":"2023","journal-title":"Arthritis Care Res"},{"key":"2025112721051476000_11.4.e006071.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0087-3"},{"key":"2025112721051476000_11.4.e006071.7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/acr.23871","article-title":"2019 American College of Rheumatology\/Arthritis Foundation Guideline for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis\u2013Associated Uveitis","volume":"71","author":"Angeles\u2010Han","year":"2019","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2025112721051476000_11.4.e006071.8","unstructured":"Rayyan . 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