{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:22:16Z","timestamp":1788434536103,"version":"build-2803163510"},"reference-count":48,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"unspecified","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2025,11,23]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Sj\u00f6gren\u2019s is a chronic systemic autoimmune disease characterised by dryness symptoms (eyes, mouth, skin), alongside other systemic manifestations such as fatigue, muscle and joint pain, neuropathies and organ involvement. Despite its prevalence, research into the patient perspective of Sj\u00f6gren\u2019s is limited. This study aimed to better understand the burden, unmet needs and treatment satisfaction among adults with Sj\u00f6gren\u2019s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected using a cross-sectional survey of adult patients with Sj\u00f6gren\u2019s across China, France, Germany, Italy, Japan, Spain, the UK and the USA (December 2023 to September 2024). Patients were recruited via physicians or patient advocacy organisations. The Work Productivity and Activity Impairment (WPAI) tool assessed work-related productivity and daily activity impact. Analyses were descriptive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1155 patients completed the survey. Mean (SD) age was 54.5 (13.0) years; 88.2% were female and 95.3% white. Most frequently reported symptoms were dry mouth, dry eyes, dry skin, physical fatigue\/tiredness and joint stiffness\/soreness. High emotional burden from Sj\u00f6gren\u2019s (rating 5\u20137 out of 7) was reported by 57.7%. WPAI scores showed 46.6% work and 48.4% activity impairment. Of those receiving prescription therapy, 77.2% were dissatisfied and\/or believed disease control could improve. Among those not fully satisfied, 52.9% felt current treatments only addressed symptoms, not the underlying systemic nature of Sj\u00f6gren\u2019s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>Spotlight on Sj\u00f6gren\u2019s<\/jats:italic>\n                      study reveals the substantial, multifaceted burden of Sj\u00f6gren\u2019s, extending beyond dryness to significantly impair physical, emotional and functional well-being. Findings underscore the need for comprehensive, patient-centred care and therapies addressing both symptoms and the underlying systemic disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2025-006166","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:35:32Z","timestamp":1768232132000},"page":"e006166","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Spotlight on Sj\u00f6gren\u2019s: a patient perspective on burden of illness and unmet needs \u2013 results from a real-world survey"],"prefix":"10.1136","volume":"12","author":[{"given":"Jessica","family":"Marvel","sequence":"first","affiliation":[{"name":"Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayle","family":"Kenney","sequence":"additional","affiliation":[{"name":"Novartis AG, Basel, BS, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Church","sequence":"additional","affiliation":[{"name":"Sjogren\u2019s Foundation Inc, Reston, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"},{"name":"HRB Clinical Research Facility, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fox","sequence":"additional","affiliation":[{"name":"Rheumatology, Scripps Memorial Hospital La Jolla, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4955-2300","authenticated-orcid":false,"given":"Kaori","family":"Komori","sequence":"additional","affiliation":[{"name":"Environmental Medicine, Kochi Medical School, Nankoku, Japan"},{"name":"Japanese Sj\u00f6gren\u2019s Association for Patients, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-9447","authenticated-orcid":false,"given":"Gavin","family":"Harper","sequence":"additional","affiliation":[{"name":"Adelphi Real World, Bollington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Howard","sequence":"additional","affiliation":[{"name":"Adelphi Real World, Bollington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5453-8089","authenticated-orcid":false,"given":"Thom","family":"Dewar","sequence":"additional","affiliation":[{"name":"Adelphi Real World, Bollington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Fox","sequence":"additional","affiliation":[{"name":"Adelphi Real World, Bollington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026090304052911000_12.1.e006166.1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020658","article-title":"The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sj\u00f6gren\u2019s Syndrome","volume":"22","author":"Chivasso","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026090304052911000_12.1.e006166.2","doi-asserted-by":"crossref","unstructured":"Mihai A , Caruntu C , Jurcut C , et al . 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