{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:17:43Z","timestamp":1787912263214,"version":"build-2784847793"},"reference-count":37,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"unspecified","delay-in-days":19,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011699","name":"Siemens Healthineers","doi-asserted-by":"publisher","award":["in-kind supported with RF\/ACPA assays and technica"],"award-info":[{"award-number":["in-kind supported with RF\/ACPA assays and technica"]}],"id":[{"id":"10.13039\/501100011699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014386","name":"Abbott Diagnostics","doi-asserted-by":"publisher","award":["in-kind supported with RF\/ACPA assays and technica"],"award-info":[{"award-number":["in-kind supported with RF\/ACPA assays and technica"]}],"id":[{"id":"10.13039\/100014386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","award":["in-kind supported with RF\/ACPA assays and technica"],"award-info":[{"award-number":["in-kind supported with RF\/ACPA assays and technica"]}],"id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011878","name":"Flemish Government","doi-asserted-by":"crossref","award":["AI Research Program"],"award-info":[{"award-number":["AI Research Program"]}],"id":[{"id":"10.13039\/501100011878","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Orgentec","award":["in-kind supported with RF\/ACPA assays and technica"],"award-info":[{"award-number":["in-kind supported with RF\/ACPA assays and technica"]}]},{"DOI":"10.13039\/100016545","name":"Roche Diagnostics","doi-asserted-by":"publisher","award":["in-kind supported with RF\/ACPA assays and technica"],"award-info":[{"award-number":["in-kind supported with RF\/ACPA assays and technica"]}],"id":[{"id":"10.13039\/100016545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2026,6,23]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In the American College of Rheumatology\/European Alliance of Rheumatology Associations 2010 classification criteria for rheumatoid arthritis (RA), rheumatoid factor (RF) and anti-citrullinated protein\/peptide antibodies (ACPA) are assigned the same weight, although ACPA have proven more specific than RF. We aimed to refine the serological weight factors for RA classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Diagnostic samples from 398 patients with RA and 448 diseased controls (DC) were evaluated with RF and ACPA assays from five different manufacturers. A grid search was conducted across all possible integer score pairs for RF and ACPA to identify the weighting combination that optimised the specificity of RA classification. This combination was applied in a refined scoring system (RSS) for three confirmatory cohorts comprising, respectively, 67, 157 and 132 patients with RA and 441, 153 and 193 DC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings<\/jats:title>\n                    <jats:p>In the investigative cohort, the optimal combination of weighting scores was characterised by higher scores for ACPA, higher antibody levels and double RF\/ACPA positivity.<\/jats:p>\n                    <jats:p>Applying the optimal combination of weighting scores decreased misclassification compared with the 2010 RA classification criteria, minimally affecting sensitivity. For seropositive patients, RSS significantly lowered misclassification from 38.3\u201355.8% to 15.0\u201326.9%.<\/jats:p>\n                    <jats:p>The improved specificity of RSS (compared with the 2010 criteria) was validated in the confirmatory cohorts. Considering only seropositive patients, the RSS significantly decreased RA misclassification (8.6\u201336.8% vs 20.0\u201378.9%), minimally affecting the sensitivity (86.7\u201397.3% vs 86.7\u201396.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation<\/jats:title>\n                    <jats:p>Serological weight factors for RA classification can be improved by taking into account the antibody type, the antibody levels and single or combined positivity. The application of an RSS reduced the number of RA misclassifications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2026-007007","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:57:28Z","timestamp":1784660248000},"page":"e007007","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Refining serological scores in rheumatoid arthritis classification: an international study"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct86668322","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3462-7288","authenticated-orcid":false,"given":"Lieve","family":"Van Hoovels","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium"},{"name":"Department of Laboratory Medicine, AZORG Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Chatzichristos","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Irure-Ventura","sequence":"additional","affiliation":[{"name":"Immunopathology Group, Department of Immunology, Marqu\u00e9s de Valdecilla University Hospital-IDIVAL, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphn\u00e9","family":"Vandebeek","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Lodewijckx","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Vander Cruyssen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, AZORG, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sieghart","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien","family":"Bonroy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ghent University, Gent, Belgium"},{"name":"Department of Diagnostic Sciences, Ghent University, Gent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rille","family":"Pullerits","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital Gothenburg, Gothenburg, Sweden"},{"name":"Department of Rheumatology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u0161a","family":"\u010cu\u010dnik","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia"},{"name":"Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dahle","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingmar","family":"Heijnen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid","family":"Benkhadra","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bogaert","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, AZORG Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Van Den Bremt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, AZORG Hospital, Aalst, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Van Liedekerke","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, AZ Sint-Elisabeth, Zottegem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Vanheule","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, AZ Rivierenland, Bornem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Robbrecht","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, AZ Sint-Lucas, Bruges, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger B","family":"Mueller","sequence":"additional","affiliation":[{"name":"Rheumazentrum Ostschweiz GmbH, Waisenhausstr, St.Gallen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Kyburz","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-2048","authenticated-orcid":false,"given":"Christopher","family":"Sj\u00f6wall","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-1477","authenticated-orcid":false,"given":"Alf","family":"Kastbom","sequence":"additional","affiliation":[{"name":"Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Je\u0161e","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boja","family":"Jovancevic","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9227-257X","authenticated-orcid":false,"given":"Peggy","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospital Ghent and VIB Inflammation Research Center, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"De Vos","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium"},{"name":"Department of Development and Regeneration KU Leuven, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"L\u00f3pez-Hoyos","sequence":"additional","affiliation":[{"name":"Immunopathology Group, Department of Immunology, Marqu\u00e9s de Valdecilla University Hospital-IDIVAL, Santander, Spain"},{"name":"Department of Molecular Biology, University of Cantabria, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5089-7405","authenticated-orcid":false,"given":"G\u00fcnter","family":"Steiner","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria"},{"name":"Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0340-3580","authenticated-orcid":false,"given":"Patrick","family":"Verschueren","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department of Development and Regeneration KU Leuven, University Hospital Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-8485","authenticated-orcid":false,"given":"Xavier","family":"Bossuyt","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium"},{"name":"Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,7,20]]},"reference":[{"key":"2026082702000684000_12.3.e007007.1","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2026082702000684000_12.3.e007007.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"2026082702000684000_12.3.e007007.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201909"},{"key":"2026082702000684000_12.3.e007007.4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"2026082702000684000_12.3.e007007.5","doi-asserted-by":"publisher","DOI":"10.1002\/art.30100"},{"key":"2026082702000684000_12.3.e007007.6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq442"},{"key":"2026082702000684000_12.3.e007007.7","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.143560"},{"key":"2026082702000684000_12.3.e007007.8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.142299"},{"key":"2026082702000684000_12.3.e007007.9","doi-asserted-by":"publisher","DOI":"10.1186\/ar2903"},{"key":"2026082702000684000_12.3.e007007.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.05.007"},{"key":"2026082702000684000_12.3.e007007.11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209991"},{"key":"2026082702000684000_12.3.e007007.12","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2016-211039","article-title":"Anticitrullinated protein antibodies: taking into account antibody levels improves interpretation","volume":"76","author":"Bossuyt","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"2026082702000684000_12.3.e007007.13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2025.100291","article-title":"Autoantibodies as prognostic markers in rheumatoid arthritis","volume":"10","author":"Turesson","year":"2025","journal-title":"J Transl Autoimmun"},{"key":"2026082702000684000_12.3.e007007.14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202127"},{"key":"2026082702000684000_12.3.e007007.15","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1002\/art.39297","article-title":"Autoantibodies in prediction of the development of rheumatoid arthritis among healthy relatives of patients with the disease","volume":"67","author":"Ramos\u2010Remus","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2026082702000684000_12.3.e007007.16","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209794"},{"key":"2026082702000684000_12.3.e007007.17","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.clinthera.2019.04.017","article-title":"Predicting rheumatoid arthritis in at-risk individuals","volume":"41","author":"van Boheemen","year":"2019","journal-title":"Clin Ther"},{"key":"2026082702000684000_12.3.e007007.18","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2021-002099","article-title":"Multicentre study to improve clinical interpretation of rheumatoid factor and anti-citrullinated protein\/peptide antibodies test results","volume":"8","author":"Van Hoovels","year":"2022","journal-title":"RMD Open"},{"key":"2026082702000684000_12.3.e007007.19","doi-asserted-by":"crossref","first-page":"119928","DOI":"10.1016\/j.cca.2024.119928","article-title":"Integrating pretest probability for rheumatoid arthritis with likelihood ratios of RF and ACPA to improve clinical utility of rheumatoid arthritis autoantibody testing","volume":"564","author":"Vandebeek","year":"2025","journal-title":"Clin Chim Acta"},{"key":"2026082702000684000_12.3.e007007.20","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics15020135","article-title":"Impact of likelihood ratios of rheumatoid factor and anti-cyclic citrullinated peptide antibody in clinical diagnosis of rheumatoid arthritis by two available platforms","volume":"15","author":"Irure-Ventura","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"2026082702000684000_12.3.e007007.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.122473"},{"key":"2026082702000684000_12.3.e007007.22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.655262","article-title":"Likelihood ratio approach and clinical interpretation of laboratory tests","volume":"12","author":"Fierz","year":"2021","journal-title":"Front Immunol"},{"key":"2026082702000684000_12.3.e007007.23","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/jalm\/jfaa064","article-title":"Likelihood ratios as value proposition for diagnostic laboratory tests","volume":"5","author":"Fierz","year":"2020","journal-title":"J Appl Lab Med"},{"key":"2026082702000684000_12.3.e007007.24","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212365"},{"key":"2026082702000684000_12.3.e007007.25","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"2026082702000684000_12.3.e007007.26","doi-asserted-by":"publisher","DOI":"10.1002\/art.20044"},{"key":"2026082702000684000_12.3.e007007.27","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-016-1192-x","article-title":"Antibodies against carbamylated proteins and cyclic citrullinated peptides in systemic lupus erythematosus: results from two well-defined European cohorts","volume":"18","author":"Ziegelasch","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2026082702000684000_12.3.e007007.28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/03009742.2020.1818820","article-title":"Autoantibodies are major predictors of arthritis development in patients with anti-citrullinated protein antibodies and musculoskeletal pain","volume":"50","author":"Eloff","year":"2021","journal-title":"Scand J Rheumatol"},{"key":"2026082702000684000_12.3.e007007.29","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrrheum.2016.151","article-title":"Rheumatoid arthritis: Autoantibody testing to predict response to therapy in RA","volume":"12","author":"Trouw","year":"2016","journal-title":"Nat Rev Rheumatol"},{"key":"2026082702000684000_12.3.e007007.30","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208870"},{"key":"2026082702000684000_12.3.e007007.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102405"},{"key":"2026082702000684000_12.3.e007007.32","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.ard.2025.01.021","article-title":"EULAR\/ACR risk stratification criteria for development of rheumatoid arthritis in the risk stage of arthralgia","volume":"84","author":"van Steenbergen","year":"2025","journal-title":"Ann Rheum Dis"},{"key":"2026082702000684000_12.3.e007007.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400"},{"key":"2026082702000684000_12.3.e007007.34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1096866","article-title":"The diagnostic and prognostic value of IgG and IgA anti-citrullinated protein antibodies in patients with early rheumatoid arthritis","volume":"13","author":"Sieghart","year":"2022","journal-title":"Front Immunol"},{"key":"2026082702000684000_12.3.e007007.35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2022.100142","article-title":"Impact of autoimmune serology test results on RA classification and diagnosis","volume":"5","author":"Van Hoovels","year":"2022","journal-title":"J Transl Autoimmun"},{"key":"2026082702000684000_12.3.e007007.36","doi-asserted-by":"crossref","first-page":"103537","DOI":"10.1016\/j.autrev.2024.103537","article-title":"From autoantibody test results to decision making: incorporating likelihood ratios within medical practice","volume":"23","author":"Deane","year":"2024","journal-title":"Autoimmun Rev"},{"key":"2026082702000684000_12.3.e007007.37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/clinchem\/hvad222","article-title":"Reporting likelihood ratio in autoimmune serology: just a theory or feasible in practice?","volume":"70","author":"Bossuyt","year":"2024","journal-title":"Clin Chem"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2026-007007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:47:04Z","timestamp":1787910424000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2026-007007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,20]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/rmdopen-2026-007007"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2026-007007","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}