{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:13Z","timestamp":1790618173012,"version":"4.1.0"},"reference-count":34,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"unspecified","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["General Research Fund, Project NO: 14101722"],"award-info":[{"award-number":["General Research Fund, Project NO: 14101722"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2026,8,24]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether change in bone erosion volume detected by high-resolution peripheral quantitative CT (HR-pQCT) is independently associated with functional outcome in early rheumatoid arthritis (ERA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 101 patients with ERA received 2-year tight-control treatment aiming at Simplified Disease Activity Index (SDAI) remission (SDAI \u22643.3). HR-pQCT of the second to fourth metacarpophalangeal joints was performed at baseline and at month 24 to quantify erosion parameters. Partial erosion repair was defined as a reduction of at least one erosion count or a decrease in total erosion volume exceeding the least significant change; progression was defined conversely. Functional status was assessed using the Health Assessment Questionnaire-Disability Index (HAQ-DI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 2 years, disease activity and HAQ-DI improved significantly (all p&lt;0.001) in paired analyses (n=98). Sixteen (16.3%) patients showed partial erosion repair and 38 (38.8%) erosion progression. In the partial erosion repair group, reduction in total erosion volume correlated strongly with HAQ-DI improvement (\u03c1=0.719, p=0.003). This association remained significant in linear regression analyses (\u03b2=0.607, p=0.003) independent of the contribution from change in SDAI (\u03b2=0.453, p=0.018). By contrast, among erosion progressors, change in HAQ-DI was primarily driven by improvement in SDAI (\u03b2=0.755, p&lt;0.001). Baseline swollen joint count was associated with erosion progression in univariate analysis (OR 1.177, 95% CI 1.026 to 1.349, p=0.020) and after adjustment for sex (OR 1.171, 95% CI 1.019 to 1.346, p=0.026).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HR-pQCT-detected partial repair of bone erosion was independently associated with functional improvement beyond inflammation control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/rmdopen-2026-007195","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:00:20Z","timestamp":1790614820000},"page":"e007195","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Partial bone erosion repair is independently associated with functional improvement in early rheumatoid arthritis: a 2-year prospective high-resolution peripheral quantitative CT (HR-pQCT) longitudinal study"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6898-8045","authenticated-orcid":false,"given":"Qihan","family":"Wu","sequence":"first","affiliation":[{"name":"Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze-Lok","family":"Lau","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-2948","authenticated-orcid":false,"given":"Isaac T","family":"Cheng","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin Yuet","family":"Chan","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Kitty","family":"Kwok","sequence":"additional","affiliation":[{"name":"Medicine, Queen Elizebeth Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack JW","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Clinical Research and Biostatistics, Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Lai Violet","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre of Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Hung","sequence":"additional","affiliation":[{"name":"Bone Quality and Health Centre of Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Kwok","family":"Wong","sequence":"additional","affiliation":[{"name":"Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheuk Wan","family":"Isaac Yim","sequence":"additional","affiliation":[{"name":"Medicine, Tseung Kwan O Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King Yee","family":"Shirley Ying","sequence":"additional","affiliation":[{"name":"Medicine & Geriatrics, Princess Margaret Hospital, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho","family":"So","sequence":"additional","affiliation":[{"name":"Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-Shan","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine & Therapeutics, Chinese University of Hong Kong Shaw College, Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026092810001176000_12.3.e007195.1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2009::AID-ART349>3.0.CO;2-L"},{"key":"2026092810001176000_12.3.e007195.2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.2.122"},{"key":"2026092810001176000_12.3.e007195.3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210602"},{"key":"2026092810001176000_12.3.e007195.4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30173-8. 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