{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:48:54Z","timestamp":1791982134692,"version":"4.4.0"},"reference-count":31,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"unspecified","delay-in-days":84,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["RMD Open"],"accepted":{"date-parts":[[2026,9,7]]},"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1136\/rmdopen-2026-007209","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:10:20Z","timestamp":1790179820000},"page":"e007209","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal evolution of synovial histopathology in rheumatoid arthritis across treatment periods: a large-scale analysis of 1770 surgical specimens using the Rooney score"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6895","authenticated-orcid":false,"given":"Masanori","family":"Sudo","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"},{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3517-3971","authenticated-orcid":false,"given":"Asami","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahoko","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"},{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0904-4165","authenticated-orcid":false,"given":"Sayuri","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"},{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"},{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5635-4842","authenticated-orcid":false,"given":"Kiyoshi","family":"Nakazono","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Murasawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-2966","authenticated-orcid":false,"given":"Suguru","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6441-8630","authenticated-orcid":false,"given":"Satoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Niigata Rheumatic Center, Shibata, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"2026101405101018000_12.3.e007209.1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(16)30173-8. PubMed PMID: 27156434."},{"key":"2026101405101018000_12.3.e007209.2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.39480","article-title":"2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2026101405101018000_12.3.e007209.3","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0170-5"},{"key":"2026101405101018000_12.3.e007209.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05246-0"},{"key":"2026101405101018000_12.3.e007209.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432202"},{"key":"2026101405101018000_12.3.e007209.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-015-3415-x"},{"key":"2026101405101018000_12.3.e007209.7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051113-024537"},{"key":"2026101405101018000_12.3.e007209.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1608345"},{"key":"2026101405101018000_12.3.e007209.9","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/art.41032","article-title":"Upadacitinib versus placebo or adalimumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III, double-blind, randomized controlled trial","volume":"71","author":"Fleischmann","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2026101405101018000_12.3.e007209.10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123919"},{"key":"2026101405101018000_12.3.e007209.11","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ard.2026.01.023","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update","volume":"85","author":"Smolen","year":"2026","journal-title":"Ann Rheum Dis"},{"key":"2026101405101018000_12.3.e007209.12","doi-asserted-by":"crossref","DOI":"10.1186\/ar4555","article-title":"Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics","volume":"16","author":"Dennis","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2026101405101018000_12.3.e007209.13","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000427","article-title":"Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce-Part 2: reliability and application to multiple joints of a standardised consensus-based scoring system","volume":"3","author":"Terslev","year":"2017","journal-title":"RMD Open"},{"key":"2026101405101018000_12.3.e007209.14","doi-asserted-by":"publisher","DOI":"10.1002\/art.22190"},{"key":"2026101405101018000_12.3.e007209.15","doi-asserted-by":"crossref","first-page":"i89","DOI":"10.1136\/annrheumdis-2011-200797","article-title":"Remission by imaging in rheumatoid arthritis: should this be the ultimate goal?","volume":"71(Suppl 2)","author":"van der Heijde","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2026101405101018000_12.3.e007209.16","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/art.1780310803","article-title":"Analysis of the histologic variation of synovitis in rheumatoid arthritis","volume":"31","author":"Rooney","year":"1988","journal-title":"Arthritis Rheum"},{"key":"2026101405101018000_12.3.e007209.17","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214539"},{"key":"2026101405101018000_12.3.e007209.18","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/art.40428","article-title":"Identification of three rheumatoid arthritis disease subtypes by machine learning integration of synovial histologic features and RNA sequencing data","volume":"70","author":"Orange","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2026101405101018000_12.3.e007209.19","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835fd8eb"},{"key":"2026101405101018000_12.3.e007209.20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ero.2026.02.008","article-title":"Synovial histopathology in rheumatoid arthritis treated with biological disease-modifying antirheumatic drugs: an analysis of 1593 surgical specimens using the Rooney score","volume":"2","author":"Sudo","year":"2026","journal-title":"EULAR Rheumatol Open"},{"key":"2026101405101018000_12.3.e007209.21","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"2026101405101018000_12.3.e007209.22","doi-asserted-by":"publisher","DOI":"10.1177\/028418517701800415"},{"key":"2026101405101018000_12.3.e007209.23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217344"},{"key":"2026101405101018000_12.3.e007209.24","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223413"},{"key":"2026101405101018000_12.3.e007209.25","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"2026101405101018000_12.3.e007209.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"2026101405101018000_12.3.e007209.27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105197"},{"key":"2026101405101018000_12.3.e007209.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050524"},{"key":"2026101405101018000_12.3.e007209.29","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3109\/14397595.2015.1106680","article-title":"A comparison of the ultrasonography images of the joints of patients with rheumatoid arthritis and the corresponding synovial histological findings","volume":"26","author":"Abe","year":"2016","journal-title":"Mod Rheumatol"},{"key":"2026101405101018000_12.3.e007209.30","doi-asserted-by":"publisher","DOI":"10.1002\/art.23682"},{"key":"2026101405101018000_12.3.e007209.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02508.x"}],"container-title":["RMD Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/rmdopen-2026-007209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:11:57Z","timestamp":1791979917000},"score":1,"resource":{"primary":{"URL":"https:\/\/rmdopen.bmj.com\/lookup\/doi\/10.1136\/rmdopen-2026-007209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1136\/rmdopen-2026-007209"],"URL":"https:\/\/doi.org\/10.1136\/rmdopen-2026-007209","relation":{},"ISSN":["2056-5933"],"issn-type":[{"value":"2056-5933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]}}}