{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:43:20Z","timestamp":1784310200280,"version":"3.55.0"},"reference-count":30,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2012,4,30]]},"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To obtain health-related quality of life valuations (ie, utilities) for human papillomavirus (HPV)-related cancer health states of vulval, vaginal, penile, anal and oropharyngeal cancers for use in modelling cost-effectiveness of prophylactic HPV vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Written case descriptions of each HPV-associated cancer describing the \u2018average\u2019 patient surviving after the initial cancer diagnosis and treatment were developed in consultation with oncology clinicians. A general overview, standard gamble questionnaire for each health state and a quiz was conducted in 120 participants recruited from the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the included population sample (n=99), the average age was 43\u2005years (range = 18\u201370\u2005years) with 54% men, 44% never married\/43% married, 76% education beyond year 12 and 39% employed full-time. The utility values for the five health states were 0.57 (95% CI 0.52 to 0.62) for anal cancer, 0.58 (0.53 to 0.63) for oropharyngeal cancer, 0.59 (0.54 to 0.64) for vaginal cancer, 0.65 (0.60 to 0.70) for vulval cancer and 0.79 (0.74 to 0.84) for penile cancer. Participants demonstrated a very good understanding of the symptoms, diagnosis and treatment of these cancers with a mean score of 9 (SD=1.1) on a 10-item quiz.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides utility estimates for the specific HPV-related cancers of vulval, vaginal, penile, anal and oropharyngeal cancers valued by a general population sample using standard gamble. The results demonstrate considerable quality of life impact associated with surviving these cancers that will be important to incorporate into modelling cost-effectiveness of prophylactic HPV vaccination in different populations.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2011-050161","type":"journal-article","created":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:47:22Z","timestamp":1338338842000},"page":"517-521","source":"Crossref","is-referenced-by-count":31,"title":["Quality of life valuations of HPV-associated cancer health states by the general population"],"prefix":"10.1136","volume":"88","author":[{"given":"E Lynne","family":"Conway","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Chip","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy L","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Wain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"2024051320481051000_88.7.517.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.008"},{"key":"2024051320481051000_88.7.517.2","doi-asserted-by":"publisher","DOI":"10.1071\/SH10018"},{"key":"2024051320481051000_88.7.517.3","first-page":"347","article-title":"Human papillomavirus disease and vaccines in adolescents","volume":"21","author":"Moscicki","year":"2010","journal-title":"Adolesc Med State Art Rev"},{"key":"2024051320481051000_88.7.517.4","doi-asserted-by":"publisher","DOI":"10.1002\/hec.1278"},{"key":"2024051320481051000_88.7.517.5","unstructured":"Myers ER Green S Lipkus I . Patient preferences for health states related to HPV infection: visual analog scales vs time trade-off elicitation. Proceedings of 21st International Papillomavirus Conference. Mexico City, Mexico, 2004. Abstract 542."},{"key":"2024051320481051000_88.7.517.6","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2011-050073"},{"key":"2024051320481051000_88.7.517.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3884"},{"key":"2024051320481051000_88.7.517.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23744"},{"key":"2024051320481051000_88.7.517.9","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9905-2"},{"key":"2024051320481051000_88.7.517.10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23745"},{"key":"2024051320481051000_88.7.517.11","unstructured":"NCCN Clinical Practice Guidelines in Oncology\u2014Head and Neck Cancers. National Comprehensive Cancer Network. 2010. http:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/head-and-neck.pdf (accessed Mar 2010)."},{"key":"2024051320481051000_88.7.517.12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23743"},{"key":"2024051320481051000_88.7.517.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.04.016"},{"key":"2024051320481051000_88.7.517.14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01181.x"},{"key":"2024051320481051000_88.7.517.15","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23757"},{"key":"2024051320481051000_88.7.517.16","unstructured":"CancerHelp UK. Vaginal Cancer. Cancer Research UK. 2011. http:\/\/www.cancerhelp.org.uk\/type\/vaginal-cancer\/ (accessed May 2011)."},{"key":"2024051320481051000_88.7.517.17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.clon.2004.05.007","article-title":"Quality of life after non-surgical treatment of anal carcinoma: a case control study of long-term survivors","volume":"16","author":"Jephcott","year":"2004","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"2024051320481051000_88.7.517.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01157.x"},{"key":"2024051320481051000_88.7.517.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1048-891X.2004.14524.x"},{"key":"2024051320481051000_88.7.517.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.027"},{"key":"2024051320481051000_88.7.517.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-9-8"},{"key":"2024051320481051000_88.7.517.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2006.07.005"},{"key":"2024051320481051000_88.7.517.23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8005"},{"key":"2024051320481051000_88.7.517.24","doi-asserted-by":"publisher","DOI":"10.1159\/000086982"},{"key":"2024051320481051000_88.7.517.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02959-0"},{"key":"2024051320481051000_88.7.517.26","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199915020-00001"},{"key":"2024051320481051000_88.7.517.27","doi-asserted-by":"crossref","unstructured":"Drummond M Sculpher MJ Torrance GW . Methods for the Economic Evaluation of Health Care Programs. 3rd edn. Oxford: Oxford University Press, 2005.","DOI":"10.1093\/oso\/9780198529446.001.0001"},{"key":"2024051320481051000_88.7.517.28","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(91)90156-7"},{"key":"2024051320481051000_88.7.517.29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605187"},{"key":"2024051320481051000_88.7.517.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2009.00509.x"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2011-050161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T04:07:14Z","timestamp":1715659634000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2011-050161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,11,19]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1136\/sextrans-2011-050161"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2011-050161","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]}}}