{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T16:01:44Z","timestamp":1768579304719,"version":"3.49.0"},"reference-count":32,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2011,12,10]]},"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate molecular epidemiology of<jats:italic>Chlamydia trachomatis<\/jats:italic>infection among patients recruited from different clinic settings in Shenzhen, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 2534 patients from the sexually transmitted disease (STD) clinics, obstetrics and gynaecology (OBGYN) clinics and genitourinary medicine (GUM) clinics in 34 hospitals participated in the study. The<jats:italic>C trachomatis<\/jats:italic>infection was determined using COBAS Amplicor system. DNA extracted in<jats:italic>C trachomatis<\/jats:italic>-positive samples was amplified using a nested PCR based on<jats:italic>omp<\/jats:italic>A gene and then genotyped using a microsphere suspension array.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence of genital<jats:italic>C trachomatis<\/jats:italic>infection was 17.7%. The prevalence in patients at STD or GUM clinics was significantly higher than that in patients at OBGYN clinics. Being male (adjusted OR (AOR) 2.5, 95% CI 1.8 to 3.4), having no consistent use of a condom with casual partners in the past 3\u2005months (AOR 1.7, 95% CI 1.1 to 2.8) and having any STD symptoms (AOR 3.3, 95% CI 2.0 to 5.4) were independently associated with<jats:italic>C trachomatis<\/jats:italic>infection. Eight genotypes were identified. The most prevalent genotypes were F (22.3%), E (22.0%) and D\/Da (12.7%). Other genotypes were G\/Ga (8.0%), J (7.3%), K (2.7%), H (2.7%) and I\/Ia (0.4%). Eighty-two samples (18.3%) were infected with multiple genotypes. Genotype D\/Da among patients from GUM clinics was more common than those from STD or OBGYN clinics. Infections with genotypes G and F were statistically associated with abnormal vaginal discharge (p=0.001) and being married (p=0.014), respectively. Infection with multiple genotypes was more common among patients with a higher income (p=0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A substantial prevalence of genital<jats:italic>C trachomatis<\/jats:italic>infection in Shenzhen suggests the importance of detection and treatment of the infection in high-risk groups.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2011-050163","type":"journal-article","created":{"date-parts":[[2012,1,21]],"date-time":"2012-01-21T05:29:07Z","timestamp":1327123747000},"page":"272-277","source":"Crossref","is-referenced-by-count":20,"title":["Molecular epidemiology of genital<i>Chlamydia trachomatis<\/i>infection in Shenzhen, 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