{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T05:13:33Z","timestamp":1715663613268},"reference-count":28,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2012,9,3]]},"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the risk factors for infection and the outcome of pregnancy in women diagnosed with syphilis using a molecular approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case-control study of pregnant women admitted to a maternity ward, with the cases classified as early or latent maternal syphilis, based on clinical-serological diagnoses. The DNA of total peripheral blood was used to detect the<jats:italic>polA<\/jats:italic>gene using nested PCR (nPCR). The case and control groups were divided into subgroups based on whether the birth was successful (infant survived) or had a lethal outcome (miscarriage, stillbirth or neonatal death).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of maternal syphilis was 1% (237\/25\u2005600), considering both those that had live births (71.3%, 169\/237) and those with a lethal outcome (28.7%, 68\/237), with a higher detection rate being provided by the nPCR in women with early syphilis. The cases of nPCR(+) congenital syphilis were more frequent in the women with early syphilis, nPCR(+) mothers and those who did not have treatment during the prenatal. The risk of maternal syphilis was greater in women who had not received preventive counselling, initiated sexual activity at 16\u2005years of age or younger, had multiple partners, used drugs, were from households with a low income and poor sanitation, and had a history of miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk factors for congenital syphilis are closely related to the health of the mother, reflecting the lack of adequate prenatal care. The high frequency of maternal syphilis was associated in particular to the socio-economic conditions of the mother and her sexual and reproductive health.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2012-050552","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T01:51:48Z","timestamp":1349401908000},"page":"257-261","source":"Crossref","is-referenced-by-count":10,"title":["Risk factors and pregnancy outcomes in women with syphilis diagnosed using a molecular approach"],"prefix":"10.1136","volume":"89","author":[{"given":"Charliana","family":"Casal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliete da Cunha","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Cristina de Oliveira","family":"Corvelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"2024051321070449000_89.3.257.1","unstructured":"World Health Organization. Global prevalence and incidence of selected curable sexually transmitted infection overview and estimates. Geneva: WHO, 2001: 43."},{"key":"2024051321070449000_89.3.257.2","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2005.06.005"},{"key":"2024051321070449000_89.3.257.3","unstructured":"Brasil. Programa Nacional de DST e AIDS. Diretrizes para o controle da s\u00edfilis cong\u00eanita. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2005."},{"key":"2024051321070449000_89.3.257.4","first-page":"768","article-title":"Informes T\u00e9cnicos Institucionais: S\u00edfilis Cong\u00eanita e s\u00edfilis na gesta\u00e7\u00e3o","volume":"43","year":"2008","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"2024051321070449000_89.3.257.5","unstructured":"Minist\u00e9rio da Sa\u00fade. Boletim Epidemiol\u00f3gico\u2014DST\/AIDS. Bras\u00edlia: Programa Nacional de DST\/AIDS, 2008."},{"key":"2024051321070449000_89.3.257.6","unstructured":"Brasil. Secretaria de vigil\u00e2ncia em sa\u00fade. Curso B\u00e1sico de Vigil\u00e2ncia Epidemiol\u00f3gica em S\u00edfilis Cong\u00eanita, S\u00edfilis em Gestante, Infec\u00e7\u00e3o pelo HIV em Gestantes e Crian\u00e7as Expostas. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2006:216 p."},{"key":"2024051321070449000_89.3.257.7","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000258130.07476.e3"},{"key":"2024051321070449000_89.3.257.8","first-page":"402","article-title":"Economic and programmatic aspects of congenital syphilis prevention","volume":"82","author":"Schmid","year":"2004","journal-title":"Bull World Health Organ"},{"key":"2024051321070449000_89.3.257.9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2105\/AJPH.88.4.597","article-title":"Risk Factors for syphilis congenital in infants of women with syphilis in South Carolina","volume":"88","author":"Mobley","year":"1998","journal-title":"Am J Public Health"},{"key":"2024051321070449000_89.3.257.10","doi-asserted-by":"publisher","DOI":"10.1097\/01.OLQ.0000105003.72411.FB"},{"key":"2024051321070449000_89.3.257.11","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822011005000047"},{"key":"2024051321070449000_89.3.257.12","unstructured":"Schmid G Rowley JT Samuelson J . World Health Organization (WHO) 2005 Global Estimates of the Incidence and Prevalence of Sexually Transmitted Infections (STIs). WHO\/CDC Symposium: Congenital Syphilis and the 2005 WHO Estimates of STI Incidence and Prevalence: Using the Second to Help Eliminate the First; 2009."},{"key":"2024051321070449000_89.3.257.13","unstructured":"Valderrama J Zacar\u00edas F . Eliminaci\u00f3n de s\u00edfilis cong\u00eanita em Am\u00e9rica Latina y El Caribe: marco de referencia para su implementaci\u00f3n. Washington, DC: OPS, 2005."},{"key":"2024051321070449000_89.3.257.14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S1020-49892004000900012","article-title":"S\u00edfilis materna y s\u00edfilis cong\u00eanita em Am\u00e9rica Latina: um problema grave de soluci\u00f3n sencilla","volume":"16","author":"Valderrama","year":"2004","journal-title":"Rev Panam Salud Publica"},{"issue":"RR-12","key":"2024051321070449000_89.3.257.15","first-page":"1","article-title":"Centers for disease control and prevention: sexually transmitted diseases treatment guidelines","volume":"59","author":"Frieden","year":"2010","journal-title":"MMWR Recomm Rep"},{"key":"2024051321070449000_89.3.257.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2007.01.019"},{"key":"2024051321070449000_89.3.257.17","unstructured":"Ayres M Ayres MJ Ayres DL . Bioestat 5.0\u2014Aplica\u00e7\u00f5es estat\u00edsticas nas \u00e1reas das ci\u00eancias biol\u00f3gicas e m\u00e9dicas. 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