{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T17:40:10Z","timestamp":1715708410512},"reference-count":7,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"accepted":{"date-parts":[[2013,4,21]]},"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Australian HIV postexposure prophylaxis (PEP) guidelines recommend<jats:italic>Chlamydia trachomatis<\/jats:italic>(CT) and<jats:italic>Neisseria gonorrheae<\/jats:italic>(NG) testing at both baseline and 2-week postexposure visits. We aimed to determine the diagnostic yield of testing at one or more visits, and predictors of infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from patients prescribed PEP at RPA Sexual Health over a 4-year period from January 2008 to December 2011. Predictors of CT\/NG were assessed by logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>282 individuals presented for PEP on 319 occasions during the study period. The majority (94.3%) were male and over 90% of presentations followed unprotected anal sexual exposures. Most (279, 87.5%) had CT\/NG testing at least once. Almost half (153, 48.0%) of baseline presentations, two-thirds (214, 67.1%) of 2-week presentations and over a quarter (88, 27.6%) of both presentations included CT\/NG testing. CT\/NG was diagnosed at baseline in eight (5.2%, 95% CI 2.3% to 10.0%) presentations. A new CT\/NG diagnosis occurred at the 2-week visit in 18 (8.4%, 95% CI 5.1% to 13.0%) presentations, of whom 7 tested negative and 11 were not tested at baseline. Over one-quarter (28.1%) of PEP recipients reported sexual contact between baseline and 2-week visits. Independent predictors of CT\/NG at baseline were recent sex work (OR 48.0, 95% CI 3.77 to 611.94); and at 2 weeks a known HIV-positive PEP exposure source (OR 3.54, 95% CI 1.04 to 12.06) and sex between baseline and 2-week visits (OR 3.63, 95% CI 1.10 to 11.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that screening PEP recipients for CT\/NG at both baseline and 2\u2005weeks may be warranted.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2013-051072","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:46:24Z","timestamp":1369269984000},"page":"604-606","update-policy":"http:\/\/dx.doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Timing and frequency of chlamydia and gonorrhoea testing in a cross-sectional study of HIV postexposure prophylaxis recipients"],"prefix":"10.1136","volume":"89","author":[{"given":"S","family":"Jamani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Gulholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Poynten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Templeton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"2024051410104330000_89.7.604.1","unstructured":"National Guidelines for Post-Exposure Prophylaxis after Non-Occupational Exposure to HIV. Australian Government Department of Health and Ageing, 2006. http:\/\/www.ashm.org.au\/images\/publications\/guidelines\/2007nationalPEPguidelines2.pdf (accessed 30 Jan 2013)."},{"key":"2024051410104330000_89.7.604.2","first-page":"1","article-title":"Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in United States: recommendations from the U.S. Department of Health and Human Services","volume":"54","author":"Centres for Disease Control and Prevention","year":"2005","journal-title":"MMWR"},{"key":"2024051410104330000_89.7.604.3","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2011.171011"},{"key":"2024051410104330000_89.7.604.4","doi-asserted-by":"publisher","DOI":"10.1086\/589299"},{"key":"2024051410104330000_89.7.604.5","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2005.014662"},{"key":"2024051410104330000_89.7.604.6","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.025684"},{"key":"2024051410104330000_89.7.604.7","doi-asserted-by":"publisher","DOI":"10.1136\/sti.75.1.3"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2013-051072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T17:12:36Z","timestamp":1715706756000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2013-051072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,10,11]]},"published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1136\/sextrans-2013-051072"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2013-051072","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,22]]}}}