{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:52:48Z","timestamp":1782175968894,"version":"3.54.5"},"reference-count":35,"publisher":"BMJ","issue":"Suppl 4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1136\/sextrans-2013-051225","type":"journal-article","created":{"date-parts":[[2013,11,15]],"date-time":"2013-11-15T14:33:46Z","timestamp":1384526026000},"page":"iv63-iv68","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Vaccine research for gonococcal infections: where are we?"],"prefix":"10.1136","volume":"89","author":[{"given":"Ann E","family":"Jerse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn D","family":"Deal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,11,15]]},"reference":[{"key":"key-10.1136\/sextrans-2013-051225-1","unstructured":"World Health Organization. Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. 2012."},{"key":"key-10.1136\/sextrans-2013-051225-2","first-page":"451","article-title":"Gonococcal infections in the adult","volume-title":"Sexually Transmitted Diseases","author":"Hook","year":"1999"},{"key":"key-10.1136\/sextrans-2013-051225-3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fmicb.2011.00124","article-title":"Vaccines for gonorrhea: can we rise to the challenge?","volume":"2","author":"Zhu","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-4","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1046\/j.1365-2958.2001.02452.x","article-title":"The adhesive property of the type IV pilus-associated component PilC1 of pathogenic Neisseria is supported by the conformational structure of the N-terminal part of the molecule","volume":"40","author":"Morand","year":"2001","journal-title":"Mol Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-5","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.vaccine.2011.12.076","article-title":"Recombinant outer membrane secretin PilQ(406\u2013770) as a vaccine candidate for serogroup B Neisseria meningitidis","volume":"30","author":"Haghi","year":"2012","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-6","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1046\/j.1462-5822.2002.t01-1-00215.x","article-title":"A co-operative interaction between Neisseria gonorrhoeae and complement receptor 3 mediates infection of primary cervical epithelial cells","volume":"4","author":"Edwards","year":"2002","journal-title":"Cell Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-7","doi-asserted-by":"crossref","first-page":"e1003373","DOI":"10.1371\/journal.ppat.1003373","article-title":"Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling","volume":"9","author":"Faulstich","year":"2013","journal-title":"PLoS Pathog"},{"key":"key-10.1136\/sextrans-2013-051225-8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fmicb.2011.00075","article-title":"The composition and metabolic phenotype of Neisseria gonorrhoeae biofilms","volume":"2","author":"Falsetta","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-9","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0882-4010(88)90038-1","article-title":"Presence of antibodies to the major anaerobically induced gonococcal outer membrane protein in sera from patients with gonococcal infections","volume":"5","author":"Clark","year":"1988","journal-title":"Microb Pathog"},{"key":"key-10.1136\/sextrans-2013-051225-10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbrc.2012.12.132","article-title":"Recombinant truncated AniA of pathogenic Neisseria elicits a non-native immune response and functional blocking antibodies","volume":"431","author":"Shewell","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.1136\/sextrans-2013-051225-11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fmicb.2011.00123","article-title":"Experimental gonococcal infection in male volunteers: cumulative experience with Neisseria gonorrhoeae strains FA1090 and MS11mkC","volume":"2","author":"Hobbs","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-12","article-title":"Vaccines against gonorrhea: current status and future challenges","author":"Jerse","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-13","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1016\/j.vaccine.2006.02.003","article-title":"Vaccine potential of the Neisseria meningitidis lactoferrin-binding proteins LbpA and LbpB","volume":"24","author":"Pettersson","year":"2006","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-14","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2013.02.009","article-title":"Structural insight into the lactoferrin receptors from pathogenic Neisseria","author":"Noinaj","year":"2013","journal-title":"J Struct Biol"},{"key":"key-10.1136\/sextrans-2013-051225-15","article-title":"Function and regulation of Neisseria gonorrhoeae efflux pumps","volume-title":"Microbial Efflux Pumps: Current Research","author":"Zalucki","year":"2013"},{"key":"key-10.1136\/sextrans-2013-051225-16","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/IAI.70.7.3744-3751.2002","article-title":"The Neisseria lipooligosaccharide-specific \u03b1-2,3-sialyltransferase is a surface-exposed outer membrane protein","volume":"70","author":"Shell","year":"2002","journal-title":"Infect Immun"},{"key":"key-10.1136\/sextrans-2013-051225-17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/mpat.1995.0071","article-title":"Sialylation of neisserial lipopolysaccharide: a major influence on pathogenicity","volume":"19","author":"Smith","year":"1995","journal-title":"Microb Pathog"},{"key":"key-10.1136\/sextrans-2013-051225-18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fmicb.2011.00107","article-title":"Estradiol-treated female mice as surrogate hosts for Neisseria gonorrhoeae genital tract infections","volume":"2","author":"Jerse","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-19","unstructured":"Gulati S, Zheng B, Reed G, et al. Protection against vaginal colonization with Neisseria gonorrhoeae in mouse model by passive (2C7 mAb) and active immunizations using a peptide surrogate of the 2C7 LOS epitope. Abstracts of the 18th International Pathogenic Neisseria Conference, Wurzburg, Germany. Abstract #0118. 2012."},{"key":"key-10.1136\/sextrans-2013-051225-20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vaccine.2005.07.065","article-title":"Characterization of a peptide vaccine candidate mimicking an oligosaccharide epitope of Neisseria gonorrhoeae and resultant immune responses and function","volume":"24","author":"Ngampasutadol","year":"2006","journal-title":"Vaccine"},{"issue":"(Suppl 2)","key":"key-10.1136\/sextrans-2013-051225-21","doi-asserted-by":"crossref","first-page":"B87","DOI":"10.1016\/j.vaccine.2012.01.033","article-title":"The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens","volume":"30","author":"Serruto","year":"2012","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-22","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1600-0463.2012.02903.x","article-title":"Novel meningococcal 4CMenB vaccine antigens\u2014prevalence and polymorphisms of the encoding genes in Neisseria gonorrhoeae","volume":"120","author":"Hadad","year":"2012","journal-title":"APMIS"},{"key":"key-10.1136\/sextrans-2013-051225-23","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1574-6976.2010.00260.x","article-title":"Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria","volume":"35","author":"Sadarangani","year":"2011","journal-title":"FEMS Microbiol Rev"},{"key":"key-10.1136\/sextrans-2013-051225-24","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erv.10.174","article-title":"CpG DNA as a vaccine adjuvant","volume":"10","author":"Bode","year":"2011","journal-title":"Expert Rev Vaccines"},{"key":"key-10.1136\/sextrans-2013-051225-25","doi-asserted-by":"crossref","first-page":"289597","DOI":"10.1155\/2011\/289597","article-title":"Cytokines: the future of intranasal vaccine adjuvants","volume":"2011","author":"Thompson","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"key-10.1136\/sextrans-2013-051225-26","doi-asserted-by":"crossref","first-page":"e8108","DOI":"10.1371\/journal.pone.0008108","article-title":"Functional characterization of antibodies against Neisseria gonorrhoeae opacity protein loops","volume":"4","author":"Cole","year":"2009","journal-title":"PLoS One"},{"key":"key-10.1136\/sextrans-2013-051225-27","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1365-2958.2007.05745.x","article-title":"Identification of a new OmpA-like protein in Neisseria gonorrhoeae involved in the binding to human epithelial cells and in vivo colonization","volume":"64","author":"Serino","year":"2007","journal-title":"Mol Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-28","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1016\/j.vaccine.2007.07.038","article-title":"Gonococcal transferrin binding protein chimeras induce bactericidal and growth inhibitory antibodies in mice","volume":"25","author":"Price","year":"2007","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fmicb.2011.00117","article-title":"TonB-dependent transporters expressed by Neisseria gonorrhoeae","volume":"2","author":"Cornelissen","year":"2011","journal-title":"Front Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-30","doi-asserted-by":"crossref","first-page":"e1000969","DOI":"10.1371\/journal.ppat.1000969","article-title":"An outer membrane receptor of Neisseria meningitidis involved in zinc acquisition with vaccine potential","volume":"6","author":"Stork","year":"2010","journal-title":"PLoS Pathog"},{"key":"key-10.1136\/sextrans-2013-051225-31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0966-842X(02)00037-9","article-title":"The role of porins in neisserial pathogenesis and immunity","volume":"11","author":"Massari","year":"2003","journal-title":"Trends Microbiol"},{"key":"key-10.1136\/sextrans-2013-051225-32","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.4049\/jimmunol.1102746","article-title":"Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein","volume":"188","author":"Gulati","year":"2012","journal-title":"J Immunol"},{"key":"key-10.1136\/sextrans-2013-051225-33","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.vaccine.2010.12.039","article-title":"A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression","volume":"29","author":"Keiser","year":"2011","journal-title":"Vaccine"},{"key":"key-10.1136\/sextrans-2013-051225-34","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-1119(02)01208-8","article-title":"Identification of opcA gene in Neisseria polysaccharea: interspecies diversity of Opc protein family","volume":"307","author":"Zhu","year":"2003","journal-title":"Gene"},{"key":"key-10.1136\/sextrans-2013-051225-35","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1084\/jem.185.7.1173","article-title":"Highly conserved Neisseria meningitidis surface protein confers protection against experimental infection","volume":"185","author":"Martin","year":"1997","journal-title":"J Exp Med"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2013-051225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T08:53:42Z","timestamp":1601110422000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2013-051225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,15]]},"references-count":35,"journal-issue":{"issue":"Suppl 4","published-online":{"date-parts":[[2013,11,15]]},"published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1136\/sextrans-2013-051225"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2013-051225","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,15]]}}}