{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:37:48Z","timestamp":1778236668368,"version":"3.51.4"},"reference-count":30,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100002141","name":"Public Health England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1136\/sextrans-2016-052583","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T02:49:52Z","timestamp":1467773392000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Drifting towards ceftriaxone treatment failure in gonorrhoea: risk factor analysis of data from the Gonococcal Resistance to Antimicrobials Surveillance Programme in England and Wales"],"prefix":"10.1136","volume":"93","author":[{"given":"K","family":"Town","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Obi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Quaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Chisholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,7,5]]},"reference":[{"key":"key-10.1136\/sextrans-2016-052583-1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1258\/ijsa.2011.011267","article-title":"UK national guideline for the management of gonorrhoea in adults, 2011","volume":"22","author":"Bignell","year":"2011","journal-title":"Int J STD AIDS"},{"key":"key-10.1136\/sextrans-2016-052583-2","first-page":"590","article-title":"Update to CDC's sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections","volume":"61","author":"Centers for Disease Control and Prevention","year":"2012","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.1136\/sextrans-2016-052583-3","article-title":"Guidelines for the management of sexually transmitted diseases. 2003","author":"WHO"},{"key":"key-10.1136\/sextrans-2016-052583-4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1586\/14787210.2014.906902","article-title":"Challenges with gonorrhea in the era of multi-drug and extensively drug resistance\u2014are we on the right track?","volume":"12","author":"Unemo","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"key":"key-10.1136\/sextrans-2016-052583-5","doi-asserted-by":"crossref","first-page":"pii: 20200","DOI":"10.2807\/ese.17.25.20200-en","article-title":"Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia, September 2011","volume":"17","author":"Unemo","year":"2012","journal-title":"Euro Surveill"},{"key":"key-10.1136\/sextrans-2016-052583-6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3201\/eid1701.100397","article-title":"Ceftriaxone-resistant Neisseria gonorrhoeae, Japan","volume":"17","author":"Ohnishi","year":"2011","journal-title":"Emerging Infect Dis"},{"key":"key-10.1136\/sextrans-2016-052583-7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/sextrans-2015-052220","article-title":"Gonorrhoea treatment position statement","volume":"91","author":"Fifer","year":"2015","journal-title":"Sex Transm Infect"},{"key":"key-10.1136\/sextrans-2016-052583-8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/QCO.0000000000000025","article-title":"Global resistance of Neisseria gonorrhoeae: when theory becomes reality","volume":"27","author":"Lewis","year":"2014","journal-title":"Curr Opin Infect Dis"},{"key":"key-10.1136\/sextrans-2016-052583-9","unstructured":"Public Health England. Surveillance of antimicrobial resistance in Neisseria gonorrhoeae. Key findings from the \u2018Gonococcal resistance to antimicrobials surveillance programme\u2019 (GRASP) and related surveillance data. 2014. https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/476582\/GRASP_2014_report_final_111115.pdf (accessed Jun 2016)."},{"key":"key-10.1136\/sextrans-2016-052583-10","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1093\/jac\/dkr332","article-title":"Emergence of a Neisseria gonorrhoeae clone showing decreased susceptibility to cefixime in England and Wales","volume":"66","author":"Chisholm","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"key-10.1136\/sextrans-2016-052583-11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/sti.2008.034843","article-title":"Epidemiology and clinical presentation of gonorrhoea in England and Wales: findings from the Gonococcal Resistance to Antimicrobials Surveillance Programme 2001\u20132006","volume":"85","author":"Delpech","year":"2009","journal-title":"Sex Transm Infect"},{"key":"key-10.1136\/sextrans-2016-052583-12","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/383047","article-title":"Rapid sequence-based identification of gonococcal transmission clusters in a large metropolitan area","volume":"189","author":"Martin","year":"2004","journal-title":"J Infect Dis"},{"key":"key-10.1136\/sextrans-2016-052583-13","doi-asserted-by":"crossref","first-page":"pii: 20358","DOI":"10.2807\/ese.18.03.20358-en","article-title":"Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone","volume":"18","author":"Chisholm","year":"2013","journal-title":"Euro Surveill"},{"key":"key-10.1136\/sextrans-2016-052583-14","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1128\/AAC.00325-11","article-title":"Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone","volume":"55","author":"Ohnishi","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.1136\/sextrans-2016-052583-15","doi-asserted-by":"crossref","first-page":"pii: 20862","DOI":"10.2807\/1560-7917.ES2014.19.30.20862","article-title":"Four treatment failures of pharyngeal gonorrhoea with ceftriaxone (500 mg) or cefotaxime (500 mg), Sweden, 2013 and 2014","volume":"19","author":"Golparian","year":"2014","journal-title":"Euro Surveill"},{"key":"key-10.1136\/sextrans-2016-052583-16","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/OLQ.0000000000000185","article-title":"Risk factors for antimicrobial-resistant Neisseria gonorrhoeae in Europe","volume":"41","author":"Cole","year":"2014","journal-title":"Sex Transm Dis"},{"key":"key-10.1136\/sextrans-2016-052583-17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/OLQ.0000000000000218","article-title":"Trends in antimicrobial resistance in Neisseria gonorrhoeae isolated from Guangzhou, China, 2000 to 2005 and 2008 to 2013","volume":"42","author":"Cao","year":"2015","journal-title":"Sex Transm Dis"},{"key":"key-10.1136\/sextrans-2016-052583-18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0255-0857.148374","article-title":"Rising trend of antimicrobial resistance among Neisseria gonorrhoeae isolates and the emergence of N. gonorrhoeae isolate with decreased susceptibility to ceftriaxone","volume":"33","author":"Bharara","year":"2015","journal-title":"Indian J Med Microbiol"},{"key":"key-10.1136\/sextrans-2016-052583-19","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S1473-3099(13)70143-9","article-title":"Decreased susceptibility to cephalosporins among gonococci: data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in England and Wales, 2007\u20132011","volume":"13","author":"Ison","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"key-10.1136\/sextrans-2016-052583-20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/OLQ.0000000000000223","article-title":"Can previous first-line therapies for Neisseria gonorrhoeae be targeted to specific patient subgroups to treat gonorrhea?","volume":"42","author":"Town","year":"2015","journal-title":"Sex Transm Dis"},{"key":"key-10.1136\/sextrans-2016-052583-21","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJMp1112456","article-title":"The emerging threat of untreatable gonococcal infection","volume":"366","author":"Bolan","year":"2012","journal-title":"N Engl J Med"},{"key":"key-10.1136\/sextrans-2016-052583-22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.idc.2013.08.001","article-title":"Control of Neisseria gonorrhoeae in the era of evolving antimicrobial resistance","volume":"27","author":"Barbee","year":"2013","journal-title":"Infect Dis Clin North Am"},{"key":"key-10.1136\/sextrans-2016-052583-23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/sextrans-2015-052303","article-title":"How to do it: lessons identified from investigating and trying to control an outbreak of gonorrhoea in young heterosexual adults","volume":"92","author":"Foster","year":"2016","journal-title":"Sex Transm Infect"},{"key":"key-10.1136\/sextrans-2016-052583-24","doi-asserted-by":"crossref","first-page":"E19","DOI":"10.1111\/j.1749-6632.2011.06215.x","article-title":"Antibiotic resistance in Neisseria gonorrhoeae: origin, evolution, and lessons learned for the future","volume":"1230","author":"Unemo","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"key-10.1136\/sextrans-2016-052583-25","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2217\/fmb.12.117","article-title":"Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea","volume":"7","author":"Unemo","year":"2012","journal-title":"Future Microbiol"},{"key":"key-10.1136\/sextrans-2016-052583-26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1128\/AAC.05760-11","article-title":"High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure","volume":"56","author":"Unemo","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key-10.1136\/sextrans-2016-052583-27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/CMR.00040-10","article-title":"Review and international recommendation of methods for typing Neisseria gonorrhoeae isolates and their implications for improved knowledge of gonococcal epidemiology, treatment, and biology","volume":"24","author":"Unemo","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"key-10.1136\/sextrans-2016-052583-28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S1473-3099(13)70693-5","article-title":"Genomic epidemiology of Neisseria gonorrhoeae with reduced susceptibility to cefixime in the USA: a retrospective observational study","volume":"14","author":"Grad","year":"2014","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"key-10.1136\/sextrans-2016-052583-29","doi-asserted-by":"crossref","first-page":"iv52","DOI":"10.1136\/sextrans-2012-050913","article-title":"Current and future treatment options for gonorrhoea","volume":"89","author":"Ison","year":"2013","journal-title":"Sex Transm Infect"},{"key":"key-10.1136\/sextrans-2016-052583-30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/sextrans-2014-051730","article-title":"Will use of combination cephalosporin\/azithromycin therapy forestall resistance to cephalosporins in Neisseria gonorrhoeae?","volume":"91","author":"Rice","year":"2015","journal-title":"Sex Transm Infect"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2016-052583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T19:24:57Z","timestamp":1656789897000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2016-052583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,5]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,18]]},"published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1136\/sextrans-2016-052583"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2016-052583","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,5]]}}}