{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:55:04Z","timestamp":1785531304795,"version":"3.56.0"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe a series of extrarectal lymphogranuloma venereum (LGV) cases diagnosed in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive LGV cases confirmed at the French Reference Centre for chlamydiae with an extrarectal sample from January 2010 to December 2015 were included. The first part of the study consisted of a retrospective case note review and analysis. In a second part, the complete <jats:italic>omp<\/jats:italic>A gene sequence of our samples was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 56 cases overall: 50 cases of genital LGV and six cases of pharyngeal LGV. Subjects were all men, median age 39 years, 27\/53 were HIV-positive, 47\/51 reported having sex with other men, 43\/49 reported multiple sexual partners (a mean 25 in the last 6 months). Median time from symptom onset to diagnosis was 21 days. Subjects most commonly presented with inguinal adenopathy alone (19 of 50 genital cases) and adenopathy with genital ulcer (17 of 50). Three pharyngeal cases were symptomatic. Fever was reported in 11 cases. Inguinal abscess was reported in 22 of 42 cases presenting with lymphadenopathy. Co-infections were frequent: eight cases of syphilis, four non-LGV <jats:italic>Chlamydia trachomatis<\/jats:italic> infections, one case of gonorrhoea. Cure was always achieved with doxycycline therapy but prolonged treatment was necessary in eight cases with inguinal abscess. Genotyping according to <jats:italic>omp<\/jats:italic>A sequencing showed the co-circulation of genovars L2 (16 of 42 strains successfully typed) and L2b (24 of 42). There was no association between HIV status and disease severity or genovar distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the span of 6 years, 56 extrarectal LGV cases were confirmed through genotyping in France. Extrarectal LGV seemed to share a common epidemiological background with rectal disease in terms of affected population and genovar distribution. HIV prevalence was lower than expected.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2017-053126","type":"journal-article","created":{"date-parts":[[2017,7,12]],"date-time":"2017-07-12T01:05:41Z","timestamp":1499821541000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Extra-rectal lymphogranuloma venereum in France: a clinical and molecular study"],"prefix":"10.1136","volume":"94","author":[{"given":"Arnaud","family":"Desclaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabella","family":"Touati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Neau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Laurier-Nadali\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"B\u00e9b\u00e9ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertille","family":"de Barbeyrac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Cazanave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"2020050723322993000_94.1.3.1","doi-asserted-by":"publisher","DOI":"10.1086\/509922"},{"key":"2020050723322993000_94.1.3.2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051404"},{"key":"2020050723322993000_94.1.3.3","first-page":"311","article-title":"volution Du Nombre de lymphogranulomatoses v\u00e9n\u00e9riennes rectales et d\u2019infections rectales \u00e0 Chlamydia trachomatis \u00e0 souches non L en France, 2002- 2009","volume":"26-27-28","author":"Clerc","year":"2011","journal-title":"Bull Epid\u00e9miol Hebd"},{"key":"2020050723322993000_94.1.3.4","doi-asserted-by":"publisher","DOI":"10.3201\/eid1108.050535"},{"key":"2020050723322993000_94.1.3.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03481.x"},{"key":"2020050723322993000_94.1.3.6","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1128\/JCM.32.2.528-530.1994","article-title":"Improved PCR sensitivity for direct genotyping of Chlamydia trachomatis serovars by using a nested PCR","volume":"32","author":"Lan","year":"1994","journal-title":"J Clin Microbiol"},{"key":"2020050723322993000_94.1.3.7","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.22.10881"},{"key":"2020050723322993000_94.1.3.8","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051478"},{"key":"2020050723322993000_94.1.3.9","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12256"},{"key":"2020050723322993000_94.1.3.10","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3201\/eid2211.160247","article-title":"Changing pattern of Chlamydia trachomatis strains in Lymphogranuloma Venereum Outbreak, France, 2010-2015","volume":"22","author":"Peuchant","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"2020050723322993000_94.1.3.11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.4.662"},{"key":"2020050723322993000_94.1.3.12","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2015.20.48.30076"},{"key":"2020050723322993000_94.1.3.13","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.034348"},{"key":"2020050723322993000_94.1.3.14","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2012-050915"},{"key":"2020050723322993000_94.1.3.15","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3182401a2f"},{"key":"2020050723322993000_94.1.3.16","doi-asserted-by":"publisher","DOI":"10.1136\/sti.78.2.90"},{"key":"2020050723322993000_94.1.3.17","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2008.035311"},{"key":"2020050723322993000_94.1.3.18","doi-asserted-by":"publisher","DOI":"10.3201\/EID2201.141867"},{"key":"2020050723322993000_94.1.3.19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1097\/OLQ.0000000000000453","article-title":"Did L strains responsible for Lymphogranuloma Venereum Proctitis Spread among People with Genital Chlamydia trachomatis Infection in France in 2013?","volume":"43","author":"Touati","year":"2016","journal-title":"Sex Transm Dis"},{"key":"2020050723322993000_94.1.3.20","first-page":"1090","article-title":"New lymphogranuloma venereum Chlamydia trachomatis variant, Amsterdam","volume":"11","author":"Spaargaren","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"2020050723322993000_94.1.3.21","doi-asserted-by":"crossref","unstructured":"Savage EJ , van de Laar MJ , Gallay A , et al . 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