{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:51:49Z","timestamp":1790304709095,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"8","funder":[{"name":"Institut National du Cancer-Institut de Recherche en Sant\u00e9 Publique"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Sex Transm Infect"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>New molecular techniques have allowed describing groups of bacterial communities in the vagina (community state types (CST)) that could play an important role in <jats:italic>Chlamydia trachomatis<\/jats:italic> (CT) infection. Our aim was to describe the distribution of CST in a population of young women in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was carried out in June 2015 among anonymous young women attending a STI clinic in Bordeaux, France. Participants provided a vaginal sample for CT screening and sociodemographic data. CT was diagnosed using the Aptima-combo 2 transcription-mediated-amplification assay. Vaginal microbiota composition was characterised using 16S rRNA gene amplicon sequencing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Microbiota composition and CT status were available for 132 women. CST dominated by <jats:italic>Lactobacillus crispatus<\/jats:italic> (CST-I), <jats:italic>L. iners<\/jats:italic> (CST-III) and a diversity of anaerobes (CST-IV) represented 37.1%, 38.6% and 22.0% of the sample, respectively. Twenty-one out of 132 women were CT positive. Proportions of CT-positive women were higher for samples belonging to CST-III (21.6%) and CST-IV (17.2%) than to CST-I (8.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Five CST were found in 132 young women from a STI clinic in France. These CSTs were not significantly associated with CT but higher proportions of CT-positive women were found in CST-III and CST-IV, consistent with a previous study in the Netherlands. Though our study lacked statistical power and was cross-sectional, it is a necessary first step to understand the structure of the vaginal microbiota in French women with or without infection before performing in-depth longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1136\/sextrans-2017-053346","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T17:15:23Z","timestamp":1516641323000},"page":"616-618","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Vaginal microbiota composition and association with prevalent <i>Chlamydia trachomatis<\/i> infection: a cross-sectional study of young women attending a STI clinic in France"],"prefix":"10.1136","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-0349","authenticated-orcid":false,"given":"Jeanne","family":"Tamarelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertille","family":"de Barbeyrac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Le Hen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Thi\u00e9baut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"B\u00e9b\u00e9ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Ravel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Delarocque-Astagneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"2020050723340594000_94.8.616.1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-999-0045-z"},{"key":"2020050723340594000_94.8.616.2","doi-asserted-by":"publisher","DOI":"10.1086\/367658"},{"key":"2020050723340594000_94.8.616.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1002611107"},{"key":"2020050723340594000_94.8.616.4","doi-asserted-by":"crossref","unstructured":"Newman L , Rowley J , Vander Hoorn S , et al . Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One 2015;10:e0143304. doi:10.1371\/journal.pone.0143304","DOI":"10.1371\/journal.pone.0143304"},{"key":"2020050723340594000_94.8.616.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00819.x"},{"key":"2020050723340594000_94.8.616.6","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051184.0483"},{"key":"2020050723340594000_94.8.616.7","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01043-13"},{"key":"2020050723340594000_94.8.616.8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw586"},{"key":"2020050723340594000_94.8.616.9","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199813000-00019"},{"key":"2020050723340594000_94.8.616.10","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003605"}],"container-title":["Sexually Transmitted Infections"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/sextrans-2017-053346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T10:19:59Z","timestamp":1601115599000},"score":1,"resource":{"primary":{"URL":"https:\/\/sti.bmj.com\/lookup\/doi\/10.1136\/sextrans-2017-053346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":10,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2018,11,22]]},"published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1136\/sextrans-2017-053346"],"URL":"https:\/\/doi.org\/10.1136\/sextrans-2017-053346","relation":{},"ISSN":["1368-4973","1472-3263"],"issn-type":[{"value":"1368-4973","type":"print"},{"value":"1472-3263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]}}}